David Fidock
David Fidock
Professor of Microbiology & Immunology and of Medical Sciences (in Medicine), Columbia University
Verified email at columbia.edu - Homepage
TitleCited byYear
Mutations in the P. falciparum digestive vacuole transmembrane protein PfCRT and evidence for their role in chloroquine resistance
DA Fidock, T Nomura, AK Talley, RA Cooper, SM Dzekunov, MT Ferdig, ...
Molecular cell 6 (4), 861-871, 2000
15312000
A molecular marker for chloroquine-resistant falciparum malaria
A Djimdé, OK Doumbo, JF Cortese, K Kayentao, S Doumbo, Y Diourté, ...
New England journal of medicine 344 (4), 257-263, 2001
10652001
Spiroindolones, a potent compound class for the treatment of malaria
M Rottmann, C McNamara, BKS Yeung, MCS Lee, B Zou, B Russell, ...
science 329 (5996), 1175-1180, 2010
8602010
Antimalarial drug discovery: efficacy models for compound screening
DA Fidock, PJ Rosenthal, SL Croft, R Brun, S Nwaka
Nature reviews Drug discovery 3 (6), 509-520, 2004
8442004
Malaria: progress, perils, and prospects for eradication
BM Greenwood, DA Fidock, DE Kyle, SHI Kappe, PL Alonso, FH Collins, ...
The Journal of clinical investigation 118 (4), 1266-1276, 2008
7902008
Chloroquine resistance in Plasmodium falciparum malaria parasites conferred by pfcrt mutations
ABS Sidhu, D Verdier-Pinard, DA Fidock
Science 298 (5591), 210-213, 2002
7792002
Transformation with human dihydrofolate reductase renders malaria parasites insensitive to WR99210 but does not affect the intrinsic activity of proguanil
DA Fidock, TE Wellems
Proceedings of the National Academy of Sciences 94 (20), 10931-10936, 1997
4851997
Artemisinin-based combination therapies: a vital tool in efforts to eliminate malaria
RT Eastman, DA Fidock
Nature Reviews Microbiology 7 (12), 864-874, 2009
4522009
K13-propeller mutations confer artemisinin resistance in Plasmodium falciparum clinical isolates
J Straimer, NF Gnädig, B Witkowski, C Amaratunga, V Duru, ...
Science 347 (6220), 428-431, 2015
4152015
Decreasing pfmdr1 Copy Number in Plasmodium falciparum Malaria Heightens Susceptibility to Mefloquine, Lumefantrine, Halofantrine, Quinine, and Artemisinin
ABS Sidhu, AC Uhlemann, SG Valderramos, JC Valderramos, S Krishna, ...
The Journal of infectious diseases 194 (4), 528-535, 2006
3812006
pfmdr1 mutations contribute to quinine resistance and enhance mefloquine and artemisinin sensitivity in Plasmodium falciparum
ABS Sidhu, SG Valderramos, DA Fidock
Molecular microbiology 57 (4), 913-926, 2005
3782005
Alternative Mutations at Position 76 of the Vacuolar Transmembrane Protein PfCRT Are Associated with Chloroquine Resistance and Unique Stereospecific Quinine and Quinidine …
RA Cooper, MT Ferdig, XZ Su, LMB Ursos, J Mu, T Nomura, H Fujioka, ...
Molecular pharmacology 61 (1), 35-42, 2002
2982002
Targeting tuberculosis and malaria through inhibition of enoyl reductase compound activity and structural data
MR Kuo, HR Morbidoni, D Alland, SF Sneddon, BB Gourlie, MM Staveski, ...
Journal of Biological Chemistry 278 (23), 20851-20859, 2003
2862003
Imaging of Plasmodium liver stages to drive next-generation antimalarial drug discovery
S Meister, DM Plouffe, KL Kuhen, GMC Bonamy, T Wu, SW Barnes, ...
Science 334 (6061), 1372-1377, 2011
2702011
A Worldwide Map of Plasmodium falciparum K13-Propeller Polymorphisms
D Ménard, N Khim, J Beghain, AA Adegnika, M Shafiul-Alam, O Amodu, ...
New England Journal of Medicine 374 (25), 2453-2464, 2016
2592016
The fatty acid biosynthesis enzyme FabI plays a key role in the development of liver-stage malarial parasites
M Yu, TRS Kumar, LJ Nkrumah, A Coppi, S Retzlaff, CD Li, BJ Kelly, ...
Cell host & microbe 4 (6), 567-578, 2008
2572008
Targeting Plasmodium PI(4)K to eliminate malaria
CW McNamara, MCS Lee, CS Lim, SH Lim, J Roland, A Nagle, O Simon, ...
Nature 504 (7479), 248-253, 2013
2542013
A critical role for PfCRT K76T in Plasmodium falciparum verapamil‐reversible chloroquine resistance
V Lakshmanan, PG Bray, D Verdier‐Pinard, DJ Johnson, P Horrocks, ...
The EMBO journal 24 (13), 2294-2305, 2005
2402005
Defining the role of PfCRT in Plasmodium falciparum chloroquine resistance
PG Bray, RE Martin, L Tilley, SA Ward, K Kirk, DA Fidock
Molecular microbiology 56 (2), 323-333, 2005
2272005
Structural elucidation of the specificity of the antibacterial agent triclosan for malarial enoyl acyl carrier protein reductase
R Perozzo, M Kuo, JT Valiyaveettil, R Bittman, WR Jacobs, DA Fidock, ...
Journal of Biological Chemistry 277 (15), 13106-13114, 2002
2242002
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