| Ester bond-containing tea polyphenols potently inhibit proteasome activity in vitro and in vivo S Nam, DM Smith, QP Dou Journal of Biological Chemistry 276 (16), 13322-13330, 2001 | 665 | 2001 |
| Docking of the proteasomal ATPases' carboxyl termini in the 20S proteasome's α ring opens the gate for substrate entry DM Smith, SC Chang, S Park, D Finley, Y Cheng, AL Goldberg Molecular cell 27 (5), 731-744, 2007 | 630 | 2007 |
| Mechanism of gate opening in the 20S proteasome by the proteasomal ATPases J Rabl, DM Smith, Y Yu, SC Chang, AL Goldberg, Y Cheng Molecular cell 30 (3), 360-368, 2008 | 446 | 2008 |
| ATP binding to PAN or the 26S ATPases causes association with the 20S proteasome, gate opening, and translocation of unfolded proteins DM Smith, G Kafri, Y Cheng, D Ng, T Walz, AL Goldberg Molecular cell 20 (5), 687-698, 2005 | 321 | 2005 |
| A practical review of proteasome pharmacology TA Thibaudeau, DM Smith Pharmacological reviews 71 (2), 170-197, 2019 | 307 | 2019 |
| A common mechanism of proteasome impairment by neurodegenerative disease-associated oligomers TA Thibaudeau, RT Anderson, DM Smith Nature communications 9 (1), 1097, 2018 | 303 | 2018 |
| Inhibition of the proteasome activity, a novel mechanism associated with the tumor cell apoptosis-inducing ability of genistein A Kazi, KG Daniel, DM Smith, NB Kumar, QP Dou Biochemical pharmacology 66 (6), 965-976, 2003 | 240 | 2003 |
| ATP binds to proteasomal ATPases in pairs with distinct functional effects, implying an ordered reaction cycle DM Smith, H Fraga, C Reis, G Kafri, AL Goldberg Cell 144 (4), 526-538, 2011 | 209 | 2011 |
| Tannic Acid Potently Inhibits Tumor Cell Proteasome Activity, Increases p27 and Bax Expression, and Induces G1 Arrest and Apoptosis S Nam, DM Smith, QP Dou Cancer Epidemiology Biomarkers & Prevention 10 (10), 1083-1088, 2001 | 173 | 2001 |
| Synthetic analogs of green tea polyphenols as proteasome inhibitors DM Smith, Z Wang, A Kazi, L Li, TH Chan, QP Dou Molecular medicine 8, 382-392, 2002 | 155 | 2002 |
| Proteasomes and their associated ATPases: a destructive combination DM Smith, N Benaroudj, A Goldberg Journal of structural biology 156 (1), 72-83, 2006 | 151 | 2006 |
| Docking studies and model development of tea polyphenol proteasome inhibitors: applications to rational drug design DM Smith, KG Daniel, Z Wang, WC Guida, TH Chan, QP Dou Proteins: Structure, Function, and Bioinformatics 54 (1), 58-70, 2004 | 148 | 2004 |
| Misfolded PrP impairs the UPS by interaction with the 20S proteasome and inhibition of substrate entry P Deriziotis, R André, DM Smith, R Goold, KJ Kinghorn, M Kristiansen, ... The EMBO journal 30 (15), 3065-3077, 2011 | 134 | 2011 |
| Interactions of PAN's C‐termini with archaeal 20S proteasome and implications for the eukaryotic proteasome–ATPase interactions Y Yu, DM Smith, HM Kim, V Rodriguez, AL Goldberg, Y Cheng The EMBO journal 29 (3), 692-702, 2010 | 129 | 2010 |
| Potential molecular targets of tea polyphenols in human tumor cells: significance in cancer prevention. A Kazi, DM Smith, K Daniel, S Zhong, P Gupta, ME Bosley, QP Dou In Vivo (Athens, Greece) 16 (6), 397-403, 2002 | 115 | 2002 |
| A conserved F box regulatory complex controls proteasome activity in Drosophila M Bader, S Benjamin, OL Wapinski, DM Smith, AL Goldberg, H Steller Cell 145 (3), 371-382, 2011 | 106 | 2011 |
| Green tea polyphenol epigallocatechin inhibits DNA replication and consequently induces leukemia cell apoptosis DM Smith, QP Dou International journal of molecular medicine 7 (6), 645-652, 2001 | 101 | 2001 |
| A novel β-lactam antibiotic activates tumor cell apoptotic program by inducing DNA damage DM Smith, A Kazi, L Smith, TE Long, B Heldreth, E Turos, QP Dou Molecular pharmacology 61 (6), 1348-1358, 2002 | 100 | 2002 |
| Blm10 protein promotes proteasomal substrate turnover by an active gating mechanism T Dange, D Smith, T Noy, PC Rommel, L Jurzitza, RJB Cordero, ... Journal of Biological Chemistry 286 (50), 42830-42839, 2011 | 95 | 2011 |
| Interruption of tumor cell cycle progression through proteasome inhibition: implications for cancer therapy QP Dou, DM Smith, KG Daniel, A Kazi PROGRESS IN CELL CYCLE RESEARCH. 5, 441-446, 2003 | 70 | 2003 |
Tak-Hang ChanProfessor, McGill UniversityVerified email at mcgill.ca
