| Activation of protein kinase B β and γ isoforms by insulin in vivo and by 3-phosphoinositide-dependent protein kinase-1 in vitro: comparison with protein kinase B α KS Walker, M Deak, A Paterson, K Hudson, P Cohen, DR Alessi Biochemical Journal 331 (1), 299-308, 1998 | 398 | 1998 |
| Design and synthesis of novel lactate dehydrogenase A inhibitors by fragment-based lead generation RA Ward, C Brassington, AL Breeze, A Caputo, S Critchlow, G Davies, ... Journal of medicinal chemistry 55 (7), 3285-3306, 2012 | 183 | 2012 |
| Targeting KRAS-dependent tumors with AZD4785, a high-affinity therapeutic antisense oligonucleotide inhibitor of KRAS SJ Ross, AS Revenko, LL Hanson, R Ellston, A Staniszewska, N Whalley, ... Science translational medicine 9 (394), eaal5253, 2017 | 182 | 2017 |
| Sensitivity to PI3K and AKT inhibitors is mediated by divergent molecular mechanisms in subtypes of DLBCL T Erdmann, P Klener, JT Lynch, M Grau, P Vočková, J Molinsky, ... Blood, The Journal of the American Society of Hematology 130 (3), 310-322, 2017 | 103 | 2017 |
| PI3Kα/δ inhibition promotes anti-tumor immunity through direct enhancement of effector CD8+ T-cell activity LS Carnevalli, C Sinclair, MA Taylor, PM Gutierrez, S Langdon, ... Journal for immunotherapy of cancer 6 (1), 158, 2018 | 76 | 2018 |
| Crawlable applications G Buzsaki, K Hudson, A Wang, D Lam US Patent 7,752,207, 2010 | 69 | 2010 |
| A novel DYRK1B inhibitor AZ191 demonstrates that DYRK1B acts independently of GSK3β to phosphorylate cyclin D1 at Thr286, not Thr288 AL Ashford, D Oxley, J Kettle, K Hudson, S Guichard, SJ Cook, ... Biochemical Journal 457 (1), 43-56, 2014 | 68 | 2014 |
| Novel 4-anilinoquinazolines with C-6 carbon-linked side chains: synthesis and structure–activity relationship of a series of potent, orally active, EGF receptor tyrosine kinase … LFA Hennequin, P Ballard, FT Boyle, B Delouvrié, RPA Ellston, CT Halsall, ... Bioorganic & medicinal chemistry letters 16 (10), 2672-2676, 2006 | 53 | 2006 |
| Discovery of novel imidazo [1, 2-a] pyridines as inhibitors of the insulin-like growth factor-1 receptor tyrosine kinase R Ducray, I Simpson, FH Jung, JWM Nissink, PW Kenny, M Fitzek, ... Bioorganic & medicinal chemistry letters 21 (16), 4698-4701, 2011 | 52 | 2011 |
| Functional significance of co-occurring mutations in PIK3CA and MAP3K1 in breast cancer A Avivar-Valderas, R McEwen, A Taheri-Ghahfarokhi, LS Carnevalli, ... Oncotarget 9 (30), 21444, 2018 | 49 | 2018 |
| Intermittent High-Dose Scheduling of AZD8835, a Novel Selective Inhibitor of PI3Kα and PI3Kδ, Demonstrates Treatment Strategies for PIK3CA-Dependent Breast … K Hudson, UJ Hancox, C Trigwell, R McEwen, UM Polanska, M Nikolaou, ... Molecular cancer therapeutics 15 (5), 877-889, 2016 | 42 | 2016 |
| Modeling RAS phenotype in colorectal cancer uncovers novel molecular traits of RAS dependency and improves prediction of response to targeted agents in patients J Guinney, C Ferté, J Dry, R McEwen, G Manceau, KJ Kao, KM Chang, ... Clinical Cancer Research 20 (1), 265-272, 2014 | 42 | 2014 |
| Enzymatic characterisation of USP7 deubiquitinating activity and inhibition JD Wrigley, K Eckersley, IM Hardern, L Millard, M Walters, SW Peters, ... Cell biochemistry and biophysics 60 (1), 99-111, 2011 | 36 | 2011 |
| Discovery of 1-(4-(5-(5-amino-6-(5-tert-butyl-1, 3, 4-oxadiazol-2-yl) pyrazin-2-yl)-1-ethyl-1, 2, 4-triazol-3-yl) piperidin-1-yl)-3-hydroxypropan-1-one (AZD8835): A potent and … B Barlaam, S Cosulich, B Delouvrié, R Ellston, M Fitzek, H Germain, ... Bioorganic & Medicinal Chemistry Letters 25 (22), 5155-5162, 2015 | 34 | 2015 |
| Discovery and optimization of a novel series of Dyrk1B kinase inhibitors to explore a MEK resistance hypothesis JG Kettle, P Ballard, C Bardelle, M Cockerill, N Colclough, SE Critchlow, ... Journal of medicinal chemistry 58 (6), 2834-2844, 2015 | 29 | 2015 |
| Identification of DYRK1B as a substrate of ERK1/2 and characterisation of the kinase activity of DYRK1B mutants from cancer and metabolic syndrome AL Ashford, TPJ Dunkley, M Cockerill, RA Rowlinson, LM Baak, R Gallo, ... Cellular and molecular life sciences 73, 883-900, 2016 | 27 | 2016 |
| Using a data dictionary to determine an upgrade edition of a relational database table G Buzsaki, M Warren US Patent 10,496,399, 2019 | 25 | 2019 |
| A new series of neutral 5-substituted 4-anilinoquinazolines as potent, orally active inhibitors of erbB2 receptor tyrosine kinase B Barlaam, P Ballard, RH Bradbury, R Ducray, H Germain, DM Hickinson, ... Bioorganic & medicinal chemistry letters 18 (2), 674-678, 2008 | 23 | 2008 |
| A mitotic spindle requirement for DNA damage-induced apoptosis in Chinese hamster ovary cells PA Johnson, P Clements, K Hudson, KW Caldecott Cancer research 59 (11), 2696-2700, 1999 | 23 | 1999 |
| Reducing downtime during upgrades of interrelated components in a database system G Buzaski, K Hudson, I Dujmovic, S Kadiyala, V Palakurthy US Patent 9,448,784, 2016 | 17 | 2016 |
