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Chris Radoux
Chris Radoux
Associate Director Structural Bioinformatics, Exscientia
Verified email at exscientia.co.uk
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Cited by
Cited by
Year
ChEMBL: towards direct deposition of bioassay data
D Mendez, A Gaulton, AP Bento, J Chambers, M De Veij, E Félix, ...
Nucleic acids research 47 (D1), D930-D940, 2019
15162019
The PROTACtable genome
M Schneider, CJ Radoux, A Hercules, D Ochoa, I Dunham, LP Zalmas, ...
Nature reviews Drug discovery 20 (10), 789-797, 2021
1222021
Identifying interactions that determine fragment binding at protein hotspots
CJ Radoux, TSG Olsson, WR Pitt, CR Groom, TL Blundell
Journal of medicinal chemistry 59 (9), 4314-4325, 2016
1002016
Target-based evaluation of “drug-like” properties and ligand efficiencies
PD Leeson, AP Bento, A Gaulton, A Hersey, EJ Manners, CJ Radoux, ...
Journal of medicinal chemistry 64 (11), 7210-7230, 2021
492021
Identification of new allosteric sites and modulators of AChE through computational and experimental tools
C Roca, C Requena, V Sebastián-Pérez, S Malhotra, C Radoux, C Pérez, ...
Journal of enzyme inhibition and medicinal chemistry 33 (1), 1034-1047, 2018
422018
Structure-guided fragment-based drug discovery at the synchrotron: screening binding sites and correlations with hotspot mapping
SE Thomas, P Collins, RH James, V Mendes, S Charoensutthivarakul, ...
Philosophical Transactions of the Royal Society A 377 (2147), 20180422, 2019
382019
Bispecific repurposed medicines targeting the viral and immunological arms of COVID-19
MA Redhead, CD Owen, L Brewitz, AH Collette, P Lukacik, ...
Scientific reports 11 (1), 13208, 2021
302021
Hotspots api: a python package for the detection of small molecule binding hotspots and application to structure-based drug design
PR Curran, CJ Radoux, MD Smilova, RA Sykes, AP Higueruelo, ...
Journal of chemical information and modeling 60 (4), 1911-1916, 2020
202020
Fragment hotspot mapping to identify selectivity-determining regions between related proteins
MD Smilova, PR Curran, CJ Radoux, F von Delft, JC Cole, AR Bradley, ...
Journal of Chemical Information and Modeling 62 (2), 284-294, 2022
82022
Illuminating the druggable genome through patent bioactivity data
MP Magarińos, A Gaulton, E Félix, T Kiziloren, R Arcila, TI Oprea, ...
PeerJ 11, e15153, 2023
52023
The druggable genome: Twenty years later
CJ Radoux, F Vianello, J McGreig, N Desai, AR Bradley
Frontiers in Bioinformatics 2, 958378, 2022
52022
Publisher Correction: Bispecific repurposed medicines targeting the viral and immunological arms of COVID-19
MA Redhead, CD Owen, L Brewitz, AH Collette, P Lukacik, ...
Scientific Reports 11, 2021
12021
Computational drug target tractability analysis
AR Leach, C Radoux
Academic Press, 2021
12021
832P Characterisation of EXS73565: A potent and selective MALT1 inhibitor with low drug-drug interaction risk and potential in lymphoma
M Gooyit, A Payne, C Carvalheda, D Evans, C Radoux, S Richards, ...
Annals of Oncology 34, S546-S547, 2023
2023
What fragment hit to follow and how? Using hotspots to prioritise chemistry resources
M Smilova, P Curran, C Radoux, W Pitt, J Cole, A Bradley, B Marsden
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 258, 2019
2019
Structure-guided fragment-based drug discovery at the synchrotron
SE Thomas, P Collins, RH James, V Mendes, S Charoensutthivarakul, ...
Philosophical Transactions: Mathematical, Physical and Engineering Sciences …, 2019
2019
THE OTHER SIDE OF AChE: ALLOSTERIC SITES AND MODULATORS
C Roca, C Requena, V Sebastián-Pérez, S Malhotra, C Radoux, C Pérez, ...
Military Medical Science Letters/Vojenské Zdravotnické Listy 87, 2018
2018
Applying CSD-and PDB-derived binding hotspot analysis to water molecules to aid in ligand design
C Radoux, P Sanschagrin, E Davis, W Pitt
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 252, 2016
2016
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Articles 1–18