Yi Mok
Title
Cited by
Cited by
Year
8-Substituted Pyrido [3, 4-d] pyrimidin-4 (3 H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors
V Bavetsias, RM Lanigan, GF Ruda, B Atrash, MG McLaughlin, A Tumber, ...
Journal of medicinal chemistry 59 (4), 1388-1409, 2016
602016
Mining the ChEMBL database: an efficient chemoinformatics workflow for assembling an ion channel-focused screening library
NY Mok, R Brenk
Journal of chemical information and modeling 51 (10), 2449-2454, 2011
462011
On the origins of three-dimensionality in drug-like molecules
J Meyers, M Carter, NY Mok, N Brown
Future Medicinal Chemistry 8 (14), 1753-1767, 2016
432016
Discovery of novel non-peptide inhibitors of BACE-1 using virtual high-throughput screening
NY Mok, J Chadwick, KAB Kellett, NM Hooper, AP Johnson, ...
Bioorganic & medicinal chemistry letters 19 (23), 6770-6774, 2009
342009
Locating sweet spots for screening hits and evaluating pan-assay interference filters from the performance analysis of two lead-like libraries
NY Mok, S Maxe, R Brenk
Journal of chemical information and modeling 53 (3), 534-544, 2013
212013
Increasing the coverage of medicinal chemistry-relevant space in commercial fragments screening
NY Mok, R Brenk, N Brown
Journal of chemical information and modeling 54 (1), 79, 2014
192014
A Molecular Hybridization Approach for the Design of Potent, Highly Selective, and Brain-Penetrant N-Myristoyltransferase Inhibitors
JR Harrison, S Brand, V Smith, DA Robinson, S Thompson, A Smith, ...
Journal of medicinal chemistry 61 (18), 8374-8389, 2018
172018
Discovery of biphenylacetamide-derived inhibitors of BACE1 using de novo structure-based molecular design
NY Mok, J Chadwick, KAB Kellett, E Casas-Arce, NM Hooper, ...
Journal of medicinal chemistry 56 (5), 1843-1852, 2013
172013
Applications of Systematic Molecular Scaffold Enumeration to Enrich Structure–Activity Relationship Information
NY Mok, N Brown
J. Chem. Inf. Model 57 (1), 27-35, 2017
92017
Binding to an unusual inactive kinase conformation by highly selective inhibitors of inositol-requiring enzyme 1α kinase-endoribonuclease
G Colombano, JJ Caldwell, TP Matthews, C Bhatia, A Joshi, T McHardy, ...
Journal of medicinal chemistry 62 (5), 2447-2465, 2019
82019
Optimisation of the Anti‐Trypanosoma brucei Activity of the Opioid Agonist U50488
VC Smith, LAT Cleghorn, A Woodland, D Spinks, I Hallyburton, IT Collie, ...
ChemMedChem 6 (10), 1832-1840, 2011
72011
Privileged Structures and Polypharmacology within and between Protein Families
J Meyers, NEA Chessum, S Ali, NY Mok, B Wilding, AE Pasqua, ...
ACS medicinal chemistry letters 9 (12), 1199-1204, 2018
62018
Pyrido[3,4-d]pyrimidin-4(3H)-one metabolism mediated by aldehyde oxidase is blocked by C2-substitution
A Hayes, NY Mok, M Liu, C Thai, AT Henley, B Atrash, RM Lanigan, ...
Xenobiotica 47 (9), 771-777, 2017
52017
C8-substituted pyrido [3, 4-d] pyrimidin-4 (3H)-ones: Studies towards the identification of potent, cell penetrant Jumonji C domain containing histone lysine demethylase 4 …
YV Le Bihan, RM Lanigan, B Atrash, MG McLaughlin, S Velupillai, ...
European journal of medicinal chemistry 177, 316-337, 2019
22019
Metabolism of the dual FLT-3/Aurora kinase inhibitor CCT241736 in preclinical and human in vitro models: Implication for the choice of toxicology species
FL Wood, S Shepherd, A Hayes, M Liu, K Grira, Y Mok, B Atrash, A Faisal, ...
European Journal of Pharmaceutical Sciences 139, 104899, 2019
12019
Quinoline derivatives as inhibitors of heat shock factor 1 pathway activity
K Jones, M Cheeseman, N Chessum, E Pasqua, L Evans, M Tucker, ...
US Patent App. 15/563,501, 2018
2018
Peptidomimetic inhibitors of the KDM4-subfamily of histone lysine demethylases: Transitioning from substrate to inhibitor
J Maw, YV Le Bihan, K Tomlin, NY Mok, V Bavetsias, J Blagg
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 255, 2018
2018
Exploiting the peptide-binding site to design inhibitors of the KDM4 subfamily
J Maw, YV Le Bihan, NY Mok, K Boxall, A Tumber, V Bavetsias, J Blagg
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 253, 2017
2017
P2-482: De novo design of cellular active beta-secretase inhibitors
NY Mok, J Chadwick, KAB Davey, NM Hooper, AP Johnson, ...
Alzheimer's & Dementia: The Journal of the Alzheimer's Association 4 (4 …, 2008
2008
Design, synthesis and biological evaluation of new beta-secretase inhibitors
NY Mok
University of Leeds, 2008
2008
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