|8-Substituted Pyrido [3, 4-d] pyrimidin-4 (3 H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors|
V Bavetsias, RM Lanigan, GF Ruda, B Atrash, MG McLaughlin, A Tumber, ...
Journal of medicinal chemistry 59 (4), 1388-1409, 2016
|Mining the ChEMBL database: an efficient chemoinformatics workflow for assembling an ion channel-focused screening library|
NY Mok, R Brenk
Journal of chemical information and modeling 51 (10), 2449-2454, 2011
|On the origins of three-dimensionality in drug-like molecules|
J Meyers, M Carter, NY Mok, N Brown
Future Medicinal Chemistry 8 (14), 1753-1767, 2016
|Discovery of novel non-peptide inhibitors of BACE-1 using virtual high-throughput screening|
NY Mok, J Chadwick, KAB Kellett, NM Hooper, AP Johnson, ...
Bioorganic & medicinal chemistry letters 19 (23), 6770-6774, 2009
|Locating sweet spots for screening hits and evaluating pan-assay interference filters from the performance analysis of two lead-like libraries|
NY Mok, S Maxe, R Brenk
Journal of chemical information and modeling 53 (3), 534-544, 2013
|Increasing the coverage of medicinal chemistry-relevant space in commercial fragments screening|
NY Mok, R Brenk, N Brown
Journal of chemical information and modeling 54 (1), 79, 2014
|A Molecular Hybridization Approach for the Design of Potent, Highly Selective, and Brain-Penetrant N-Myristoyltransferase Inhibitors|
JR Harrison, S Brand, V Smith, DA Robinson, S Thompson, A Smith, ...
Journal of medicinal chemistry 61 (18), 8374-8389, 2018
|Discovery of biphenylacetamide-derived inhibitors of BACE1 using de novo structure-based molecular design|
NY Mok, J Chadwick, KAB Kellett, E Casas-Arce, NM Hooper, ...
Journal of medicinal chemistry 56 (5), 1843-1852, 2013
|Binding to an unusual inactive kinase conformation by highly selective inhibitors of inositol-requiring enzyme 1α kinase-endoribonuclease|
G Colombano, JJ Caldwell, TP Matthews, C Bhatia, A Joshi, T McHardy, ...
Journal of medicinal chemistry 62 (5), 2447-2465, 2019
|Applications of Systematic Molecular Scaffold Enumeration to Enrich Structure–Activity Relationship Information|
NY Mok, N Brown
J. Chem. Inf. Model 57 (1), 27-35, 2017
|Optimisation of the Anti‐Trypanosoma brucei Activity of the Opioid Agonist U50488|
VC Smith, LAT Cleghorn, A Woodland, D Spinks, I Hallyburton, IT Collie, ...
ChemMedChem 6 (10), 1832-1840, 2011
|Privileged Structures and Polypharmacology within and between Protein Families|
J Meyers, NEA Chessum, S Ali, NY Mok, B Wilding, AE Pasqua, ...
ACS medicinal chemistry letters 9 (12), 1199-1204, 2018
|Pyrido[3,4-d]pyrimidin-4(3H)-one metabolism mediated by aldehyde oxidase is blocked by C2-substitution|
A Hayes, NY Mok, M Liu, C Thai, AT Henley, B Atrash, RM Lanigan, ...
Xenobiotica 47 (9), 771-777, 2017
|C8-substituted pyrido [3, 4-d] pyrimidin-4 (3H)-ones: Studies towards the identification of potent, cell penetrant Jumonji C domain containing histone lysine demethylase 4 …|
YV Le Bihan, RM Lanigan, B Atrash, MG McLaughlin, S Velupillai, ...
European journal of medicinal chemistry 177, 316-337, 2019
|Metabolism of the dual FLT-3/Aurora kinase inhibitor CCT241736 in preclinical and human in vitro models: Implication for the choice of toxicology species|
FL Wood, S Shepherd, A Hayes, M Liu, K Grira, Y Mok, B Atrash, A Faisal, ...
European Journal of Pharmaceutical Sciences 139, 104899, 2019
|Quinoline derivatives as inhibitors of heat shock factor 1 pathway activity|
K Jones, M Cheeseman, N Chessum, E Pasqua, L Evans, M Tucker, ...
US Patent App. 15/563,501, 2018
|Peptidomimetic inhibitors of the KDM4-subfamily of histone lysine demethylases: Transitioning from substrate to inhibitor|
J Maw, YV Le Bihan, K Tomlin, NY Mok, V Bavetsias, J Blagg
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 255, 2018
|Exploiting the peptide-binding site to design inhibitors of the KDM4 subfamily|
J Maw, YV Le Bihan, NY Mok, K Boxall, A Tumber, V Bavetsias, J Blagg
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 253, 2017
|P2-482: De novo design of cellular active beta-secretase inhibitors|
NY Mok, J Chadwick, KAB Davey, NM Hooper, AP Johnson, ...
Alzheimer's & Dementia: The Journal of the Alzheimer's Association 4 (4 …, 2008
|Design, synthesis and biological evaluation of new beta-secretase inhibitors|
University of Leeds, 2008