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Darren Hart
Darren Hart
CNRS
Verified email at ibs.fr
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Cited by
Year
The cap-snatching endonuclease of influenza virus polymerase resides in the PA subunit
A Dias, D Bouvier, T Crépin, AA McCarthy, DJ Hart, F Baudin, S Cusack, ...
Nature 458 (7240), 914-918, 2009
9952009
The structural basis for cap binding by influenza virus polymerase subunit PB2
D Guilligay, F Tarendeau, P Resa-Infante, R Coloma, T Crepin, P Sehr, ...
Nature structural & molecular biology 15 (5), 500-506, 2008
6232008
Cooperative binding of two acetylation marks on a histone tail by a single bromodomain
J Moriniere, S Rousseaux, U Steuerwald, M Soler-López, S Curtet, ...
Nature 461 (7264), 664-668, 2009
5212009
Structural insight into cap-snatching and RNA synthesis by influenza polymerase
S Reich, D Guilligay, A Pflug, H Malet, I Berger, T Crépin, D Hart, ...
Nature 516 (7531), 361-366, 2014
4652014
Structure and nuclear import function of the C-terminal domain of influenza virus polymerase PB2 subunit
F Tarendeau, J Boudet, D Guilligay, PJ Mas, CM Bougault, S Boulo, ...
Nature structural & molecular biology 14 (3), 229-233, 2007
4092007
Influenza A virus polymerase: structural insights into replication and host adaptation mechanisms
S Boivin, S Cusack, RWH Ruigrok, DJ Hart
Journal of Biological Chemistry 285 (37), 28411-28417, 2010
2932010
Host determinant residue lysine 627 lies on the surface of a discrete, folded domain of influenza virus polymerase PB2 subunit
F Tarendeau, T Crepin, D Guilligay, RWH Ruigrok, S Cusack, DJ Hart
PLoS pathogens 4 (8), e1000136, 2008
2202008
Influenza polymerase can adopt an alternative configuration involving a radical repacking of PB2 domains
E Thierry, D Guilligay, J Kosinski, T Bock, S Gaudon, A Round, A Pflug, ...
Molecular cell 61 (1), 125-137, 2016
1432016
Towards an atomic resolution understanding of the influenza virus replication machinery
RWH Ruigrok, T Crépin, DJ Hart, S Cusack
Current opinion in structural biology 20 (1), 104-113, 2010
1402010
Structure and inhibition of herpesvirus DNA packaging terminase nuclease domain
M Nadal, PJ Mas, AG Blanco, C Arnan, M Solà, DJ Hart, M Coll
Proceedings of the National Academy of Sciences 107 (37), 16078-16083, 2010
1352010
Molecular determinants for nuclear import of influenza A PB2 by importin α isoforms 3 and 7
RA Pumroy, S Ke, DJ Hart, U Zachariae, G Cingolani
Structure 23 (2), 374-384, 2015
1102015
Structural Basis for the Oligomerization of the MADS Domain Transcription Factor SEPALLATA3 in Arabidopsis
S Puranik, S Acajjaoui, S Conn, L Costa, V Conn, A Vial, R Marcellin, ...
The Plant Cell 26 (9), 3603-3615, 2014
1082014
Functional protein microarrays for parallel characterisation of p53 mutants
JM Boutell, DJ Hart, BLJ Godber, RZ Kozlowski, JM Blackburn
Proteomics 4 (7), 1950-1958, 2004
972004
Implementation of semi-automated cloning and prokaryotic expression screening: the impact of SPINE
PM Alzari, H Berglund, NS Berrow, E Blagova, D Busso, C Cambillau, ...
Acta Crystallographica Section D: Biological Crystallography 62 (10), 1103-1113, 2006
852006
The salt dependence of DNA recognition by N-κB p50: A detailed kinetic analysis of the effects on affinity and specificity
DJ Hart, RE Speight, JM Blackburn, MA Cooper, JD Sutherland
Nucleic acids research 27 (4), 1063-1069, 1999
851999
Interaction of the influenza A virus polymerase PB2 C-terminal region with importin α isoforms provides insights into host adaptation and polymerase assembly
S Boivin, DJ Hart
Journal of Biological Chemistry 286 (12), 10439-10448, 2011
842011
ESPRIT: an automated, library-based method for mapping and soluble expression of protein domains from challenging targets
H Yumerefendi, F Tarendeau, PJ Mas, DJ Hart
Journal of structural biology 172 (1), 66-74, 2010
742010
Development of a peptide that selectively activates protein phosphatase‐1 in living cells
J Chatterjee, M Beullens, R Sukackaite, J Qian, B Lesage, DJ Hart, ...
Angewandte Chemie International Edition 51 (40), 10054-10059, 2012
732012
Development of a Peptide that Selectively Activates Protein Phosphatase‐1 in Living Cells
J Chatterjee, M Beullens, R Sukackaite, J Qian, B Lesage, DJ Hart, ...
Angewandte Chemie International Edition 51 (40), 10054-10059, 2012
732012
Combinatorial library approaches for improving soluble protein expression in Escherichia coli
DJ Hart, F Tarendeau
Acta Crystallographica Section D: Biological Crystallography 62 (1), 19-26, 2006
682006
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