| α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson’s disease MHR Ludtmann, PR Angelova, MH Horrocks, ML Choi, M Rodrigues, ... Nature communications 9 (1), 2293, 2018 | 414 | 2018 |
| Different soluble aggregates of Aβ42 can give rise to cellular toxicity through different mechanisms S De, DC Wirthensohn, P Flagmeier, C Hughes, FA Aprile, FS Ruggeri, ... Nature communications 10 (1), 1541, 2019 | 172 | 2019 |
| Secondary nucleation and elongation occur at different sites on Alzheimer’s amyloid-β aggregates T Scheidt, U Łapińska, JR Kumita, DR Whiten, D Klenerman, MR Wilson, ... Science Advances 5 (4), eaau3112, 2019 | 137 | 2019 |
| The small heat shock protein Hsp27 binds α-synuclein fibrils, preventing elongation and cytotoxicity D Cox, DR Whiten, JWP Brown, MH Horrocks, R San Gil, CM Dobson, ... Journal of Biological Chemistry 293 (12), 4486-4497, 2018 | 114 | 2018 |
| Soluble aggregates present in cerebrospinal fluid change in size and mechanism of toxicity during Alzheimer’s disease progression S De, DR Whiten, FS Ruggeri, C Hughes, M Rodrigues, DI Sideris, ... Acta neuropathologica communications 7, 1-13, 2019 | 84 | 2019 |
| Single-molecule characterization of the interactions between extracellular chaperones and toxic α-synuclein oligomers DR Whiten, D Cox, MH Horrocks, CG Taylor, S De, P Flagmeier, L Tosatto, ... Cell reports 23 (12), 3492-3500, 2018 | 63 | 2018 |
| Clusterin protects neurons against intracellular proteotoxicity JM Gregory, DR Whiten, RA Brown, TP Barros, JR Kumita, JJ Yerbury, ... Acta Neuropathologica Communications 5 (81), 2017 | 58 | 2017 |
| Nanoscopic characterisation of individual endogenous protein aggregates in human neuronal cells DR Whiten, Y Zuo, L Calo, ML Choi, S De, P Flagmeier, DC Wirthensohn, ... ChemBioChem 19 (19), 2033-2038, 2018 | 56 | 2018 |
| Quantifying co-oligomer formation by α-synuclein M Iljina, AJ Dear, GA Garcia, S De, L Tosatto, P Flagmeier, DR Whiten, ... ACS nano 12 (11), 10855-10866, 2018 | 52 | 2018 |
| Rapid flow cytometric measurement of protein inclusions and nuclear trafficking DR Whiten, R San Gil, L McAlary, JJ Yerbury, H Ecroyd, MR Wilson Scientific Reports 6 (1), 31138, 2016 | 34 | 2016 |
| Flow Cytometric Measurement of the Cellular Propagation of TDP-43 aggregation R Zeineddine, DR Whiten, NE Farrawell, L McAlary, MA Hanspal, ... Prion 11 (3), 2017 | 30 | 2017 |
| Imaging protein aggregates in the serum and cerebrospinal fluid in Parkinson’s disease E Lobanova, D Whiten, FS Ruggeri, CG Taylor, A Kouli, Z Xia, D Emin, ... Brain 145 (2), 632-643, 2022 | 27 | 2022 |
| Inhibiting the Ca2+ influx induced by human CSF A Drews, S De, P Flagmeier, DC Wirthensohn, WH Chen, DR Whiten, ... Cell reports 21 (11), 3310-3316, 2017 | 25 | 2017 |
| Tumour necrosis factor induces increased production of extracellular amyloid-β-and α-synuclein-containing aggregates by human Alzheimer’s disease neurons DR Whiten, PW Brownjohn, S Moore, S De, A Strano, Y Zuo, M Haneklaus, ... Brain Communications 2 (2), fcaa146, 2020 | 19 | 2020 |
| A Platform for Site‐Specific DNA‐Antibody Bioconjugation by Using Benzoylacrylic‐Labelled Oligonucleotides J Konč, L Brown, DR Whiten, Y Zuo, P Ravn, D Klenerman, ... Angewandte Chemie 133 (49), 26109-26117, 2021 | 15 | 2021 |
| Neuroserpin and transthyretin are extracellular chaperones that preferentially inhibit amyloid formation J West, S Satapathy, DR Whiten, M Kelly, NJ Geraghty, EJ Proctor, ... Science advances 7 (50), eabf7606, 2021 | 13 | 2021 |
| Shedding light on aberrant interactions–a review of modern tools for studying protein aggregates F Kundel, L Tosatto, DR Whiten, DC Wirthensohn, MH Horrocks, ... The FEBS Journal 285 (19), 3604-3630, 2018 | 12 | 2018 |
| Single cell morphology distinguishes genotype and drug effect in Hereditary Spastic Paraplegia G Wali, S Berkovsky, DR Whiten, A Mackay-Sim, CM Sue Scientific Reports 11 (1), 16635, 2021 | 11 | 2021 |
| Alpha synuclein only forms fibrils in vitro when larger than its critical size of 70 monomers SE Sanchez, DR Whiten, G Meisl, FS Ruggeri, E Hidari, D Klenerman ChemBioChem 22 (19), 2867-2871, 2021 | 10 | 2021 |
| PINK1 signalling in neurodegenerative disease DR Whiten, D Cox, CM Sue Essays in Biochemistry 65 (7), 913-923, 2021 | 5 | 2021 |
