| Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance TR Koves, JR Ussher, RC Noland, D Slentz, M Mosedale, O Ilkayeva, ... Cell metabolism 7 (1), 45-56, 2008 | 2125 | 2008 |
| Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin MD Fullerton, S Galic, K Marcinko, S Sikkema, T Pulinilkunnil, ZP Chen, ... Nature medicine 19 (12), 1649-1654, 2013 | 878 | 2013 |
| Phosphodiesterase type 5 is highly expressed in the hypertrophied human right ventricle, and acute inhibition of phosphodiesterase type 5 improves contractility J Nagendran, SL Archer, D Soliman, V Gurtu, R Moudgil, A Haromy, ... Circulation 116 (3), 238-248, 2007 | 602 | 2007 |
| Intracellular action of matrix metalloproteinase-2 accounts for acute myocardial ischemia and reperfusion injury W Wang, CJ Schulze, WL Suarez-Pinzon, JRB Dyck, G Sawicki, R Schulz Circulation 106 (12), 1543-1549, 2002 | 565 | 2002 |
| Increased hepatic CD36 expression contributes to dyslipidemia associated with diet-induced obesity DPY Koonen, RL Jacobs, M Febbraio, ME Young, CLM Soltys, H Ong, ... diabetes 56 (12), 2863-2871, 2007 | 558 | 2007 |
| Dichloroacetate prevents and reverses pulmonary hypertension by inducing pulmonary artery smooth muscle cell apoptosis MS McMurtry, S Bonnet, X Wu, JRB Dyck, A Haromy, K Hashimoto, ... Circulation research 95 (8), 830-840, 2004 | 554 | 2004 |
| Liver-specific inhibition of ChREBP improves hepatic steatosis and insulin resistance in ob/ob mice R Dentin, F Benhamed, I Hainault, V Fauveau, F Foufelle, JRB Dyck, ... Diabetes 55 (8), 2159-2170, 2006 | 530 | 2006 |
| Akt activity negatively regulates phosphorylation of AMP-activated protein kinase in the heart S Kovacic, CLM Soltys, AJ Barr, I Shiojima, K Walsh, JRB Dyck Journal of Biological Chemistry 278 (41), 39422-39427, 2003 | 486 | 2003 |
| Inhibiting peripheral serotonin synthesis reduces obesity and metabolic dysfunction by promoting brown adipose tissue thermogenesis JD Crane, R Palanivel, EP Mottillo, AL Bujak, H Wang, RJ Ford, A Collins, ... Nature medicine 21 (2), 166-172, 2015 | 485 | 2015 |
| AMPK alterations in cardiac physiology and pathology: enemy or ally? JRB Dyck, GD Lopaschuk The Journal of physiology 574 (1), 95-112, 2006 | 480 | 2006 |
| Dichloroacetate, a metabolic modulator, prevents and reverses chronic hypoxic pulmonary hypertension in rats: role of increased expression and activity of voltage-gated … ED Michelakis, MS McMurtry, XC Wu, JRB Dyck, R Moudgil, TA Hopkins, ... Circulation 105 (2), 244-250, 2002 | 451 | 2002 |
| A pivotal role for endogenous TGF-β-activated kinase-1 in the LKB1/AMP-activated protein kinase energy-sensor pathway M Xie, D Zhang, JRB Dyck, Y Li, H Zhang, M Morishima, DL Mann, ... Proceedings of the National Academy of Sciences 103 (46), 17378-17383, 2006 | 443 | 2006 |
| Epigenetic attenuation of mitochondrial superoxide dismutase 2 in pulmonary arterial hypertension: a basis for excessive cell proliferation and a new therapeutic target SL Archer, G Marsboom, GH Kim, HJ Zhang, PT Toth, EC Svensson, ... Circulation 121 (24), 2661-2671, 2010 | 431 | 2010 |
| Activation of AMP-activated protein kinase inhibits protein synthesis associated with hypertrophy in the cardiac myocyte AYM Chan, CLM Soltys, ME Young, CG Proud, JRB Dyck Journal of Biological Chemistry 279 (31), 32771-32779, 2004 | 407 | 2004 |
| Disruption of the circadian clock within the cardiomyocyte influences myocardial contractile function, metabolism, and gene expression MS Bray, CA Shaw, MWS Moore, RAP Garcia, MM Zanquetta, DJ Durgan, ... American Journal of Physiology-Heart and Circulatory Physiology 294 (2 …, 2008 | 392 | 2008 |
| Preclinical and clinical evidence for the role of resveratrol in the treatment of cardiovascular diseases BNM Zordoky, IM Robertson, JRB Dyck Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1852 (6 …, 2015 | 378 | 2015 |
| In Vivo Gene Transfer of the O2-Sensitive Potassium Channel Kv1.5 Reduces Pulmonary Hypertension and Restores Hypoxic Pulmonary Vasoconstriction in … ZI Pozeg, ED Michelakis, MS McMurtry, B Thébaud, XC Wu, JRB Dyck, ... Circulation 107 (15), 2037-2044, 2003 | 338 | 2003 |
| Beneficial effects of trimetazidine in ex vivo working ischemic hearts are due to a stimulation of glucose oxidation secondary to inhibition of long-chain 3-ketoacyl coenzyme a … GD Lopaschuk, R Barr, PD Thomas, JRB Dyck Circulation research 93 (3), e33-e37, 2003 | 317 | 2003 |
| The emerging role of metabolomics in the diagnosis and prognosis of cardiovascular disease JR Ussher, S Elmariah, RE Gerszten, JRB Dyck Journal of the American College of Cardiology 68 (25), 2850-2870, 2016 | 311 | 2016 |
| A role for peroxisome proliferator-activated receptor α (PPARα) in the control of cardiac malonyl-CoA levels: reduced fatty acid oxidation rates and increased glucose oxidation … FM Campbell, R Kozak, A Wagner, JY Altarejos, JRB Dyck, DD Belke, ... Journal of Biological Chemistry 277 (6), 4098-4103, 2002 | 296 | 2002 |
Gary LopaschukProfessor, Pediatrics, Universit of AlbertaVerified email at ualberta.ca
