Alexander K Buell
Alexander K Buell
Professor of Protein Biophysics, Technical University of Denmark, DTU
Verified email at - Homepage
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Solution conditions determine the relative importance of nucleation and growth processes in α-synuclein aggregation
AK Buell, C Galvagnion, R Gaspar, E Sparr, M Vendruscolo, TPJ Knowles, ...
Proceedings of the National Academy of Sciences 111 (21), 7671-7676, 2014
Lipid vesicles trigger α-synuclein aggregation by stimulating primary nucleation
C Galvagnion, AK Buell, G Meisl, TCT Michaels, M Vendruscolo, ...
Nature chemical biology 11 (3), 229-234, 2015
Nanostructured films from hierarchical self-assembly of amyloidogenic proteins
TPJ Knowles, TW Oppenheim, AK Buell, DY Chirgadze, ME Welland
Nature nanotechnology 5 (3), 204-207, 2010
Mutations associated with familial Parkinson’s disease alter the initiation and amplification steps of α-synuclein aggregation
P Flagmeier, G Meisl, M Vendruscolo, TPJ Knowles, CM Dobson, ...
Proceedings of the National Academy of Sciences 113 (37), 10328-10333, 2016
Chemical properties of lipids strongly affect the kinetics of the membrane-induced aggregation of α-synuclein
C Galvagnion, JWP Brown, MM Ouberai, P Flagmeier, M Vendruscolo, ...
Proceedings of the National Academy of Sciences 113 (26), 7065-7070, 2016
The role of stable α-synuclein oligomers in the molecular events underlying amyloid formation
N Lorenzen, SB Nielsen, AK Buell, JD Kaspersen, P Arosio, BS Vad, ...
Journal of the American Chemical Society 136 (10), 3859-3868, 2014
Secondary nucleation of monomers on fibril surface dominates α-synuclein aggregation and provides autocatalytic amyloid amplification
R Gaspar, G Meisl, AK Buell, L Young, CF Kaminski, TPJ Knowles, ...
Quarterly reviews of biophysics 50, e6, 2017
Ostwald’s rule of stages governs structural transitions and morphology of dipeptide supramolecular polymers
A Levin, TO Mason, L Adler-Abramovich, AK Buell, G Meisl, C Galvagnion, ...
Nature communications 5 (1), 5219, 2014
Direct observation of heterogeneous amyloid fibril growth kinetics via two-color super-resolution microscopy
D Pinotsi, AK Buell, C Galvagnion, CM Dobson, GS Kaminski Schierle, ...
Nano letters 14 (1), 339-345, 2014
Binding of the Molecular Chaperone alpha B-Crystallin to A beta Amyloid Fibrils Inhibits Fibril Elongation
SL Shammas, CA Waudby, S Wang, AK Buell, TPJ Knowles, H Ecroyd, ...
Biophysical journal 101 (7), 1681-1689, 2011
Protein aggregation in crowded environments
DA White, AK Buell, TPJ Knowles, ME Welland, CM Dobson
Journal of the American Chemical Society 132 (14), 5170-5175, 2010
Expanding the solvent chemical space for self-assembly of dipeptide nanostructures
TO Mason, DY Chirgadze, A Levin, L Adler-Abramovich, E Gazit, ...
ACS nano 8 (2), 1243-1253, 2014
A label-free, quantitative assay of amyloid fibril growth based on intrinsic fluorescence
D Pinotsi, AK Buell, CM Dobson, GSK Schierle, CF Kaminski
ChemBioChem 14 (7), 846, 2013
Targeting the intrinsically disordered structural ensemble of α-synuclein by small molecules as a potential therapeutic strategy for Parkinson’s disease
G Toth, SJ Gardai, W Zago, CW Bertoncini, N Cremades, SL Roy, ...
PloS one 9 (2), e87133, 2014
Detailed analysis of the energy barriers for amyloid fibril growth
AK Buell, A Dhulesia, DA White, TPJ Knowles, CM Dobson, ME Welland
Angewandte Chemie International Edition 51 (21), 5247-5251, 2012
Distinct thermodynamic signatures of oligomer generation in the aggregation of the amyloid-β peptide
SIA Cohen, R Cukalevski, TCT Michaels, A Šarić, M Törnquist, ...
Nature chemistry 10 (5), 523-531, 2018
Protein microgels from amyloid fibril networks
U Shimanovich, I Efimov, TO Mason, P Flagmeier, AK Buell, A Gedanken, ...
ACS nano 9 (1), 43-51, 2015
Nanobodies raised against monomeric α-synuclein distinguish between fibrils at different maturation stages
T Guilliams, F El-Turk, AK Buell, EM O'Day, FA Aprile, EK Esbjörner, ...
Journal of molecular biology 425 (14), 2397-2411, 2013
Electrostatic effects in filamentous protein aggregation
AK Buell, P Hung, X Salvatella, ME Welland, CM Dobson, TPJ Knowles
Biophysical journal 104 (5), 1116-1126, 2013
Structural insights from lipid-bilayer nanodiscs link α-Synuclein membrane-binding modes to amyloid fibril formation
T Viennet, MM Wördehoff, B Uluca, C Poojari, H Shaykhalishahi, ...
Communications biology 1 (1), 44, 2018
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