A four-organ-chip for interconnected long-term co-culture of human intestine, liver, skin and kidney equivalents I Maschmeyer, AK Lorenz, K Schimek, T Hasenberg, AP Ramme, ... Lab on a Chip 15 (12), 2688-2699, 2015 | 865 | 2015 |
A dynamic multi-organ-chip for long-term cultivation and substance testing proven by 3D human liver and skin tissue co-culture I Wagner, EM Materne, S Brincker, U Süßbier, C Frädrich, M Busek, ... Lab on a Chip 13 (18), 3538-3547, 2013 | 560 | 2013 |
Biology-inspired microphysiological system approaches to solve the prediction dilemma of substance testing U Marx, TB Andersson, A Bahinski, M Beilmann, S Beken, FR Cassee, ... Altex 33 (3), 272, 2016 | 347 | 2016 |
Skin and hair on-a-chip: in vitro skin models versus ex vivo tissue maintenance with dynamic perfusion B Ataç, I Wagner, R Horland, R Lauster, U Marx, AG Tonevitsky, RP Azar, ... Lab on a Chip 13 (18), 3555-3561, 2013 | 312 | 2013 |
Functional coupling of human pancreatic islets and liver spheroids on-a-chip: Towards a novel human ex vivo type 2 diabetes model S Bauer, C Wennberg Huldt, KP Kanebratt, I Durieux, D Gunne, ... Scientific reports 7 (1), 14620, 2017 | 250 | 2017 |
Chip-based human liver–intestine and liver–skin co-cultures–A first step toward systemic repeated dose substance testing in vitro I Maschmeyer, T Hasenberg, A Jaenicke, M Lindner, AK Lorenz, J Zech, ... European journal of pharmaceutics and biopharmaceutics 95, 77-87, 2015 | 244 | 2015 |
Biology-inspired microphysiological systems to advance patient benefit and animal welfare in drug development U Marx, T Akabane, TB Andersson, E Baker, M Beilmann, S Beken, ... Altex 37 (3), 365, 2020 | 241 | 2020 |
‘Human-on-a-chip’developments: a translational cutting-edge alternative to systemic safety assessment and efficiency evaluation of substances in laboratory animals and man? U Marx, H Walles, S Hoffmann, G Lindner, R Horland, F Sonntag, ... Alternatives to Laboratory Animals 40 (5), 235-257, 2012 | 230 | 2012 |
Integrating biological vasculature into a multi-organ-chip microsystem K Schimek, M Busek, S Brincker, B Groth, S Hoffmann, R Lauster, ... Lab on a Chip 13 (18), 3588-3598, 2013 | 204 | 2013 |
Novel photochemical surface functionalization of polysulfone ultrafiltration membranes for covalent immobilization of biomolecules M Ulbricht, M Riedel, U Marx Journal of membrane science 120 (2), 239-259, 1996 | 179 | 1996 |
A multi-organ chip co-culture of neurospheres and liver equivalents for long-term substance testing EM Materne, AP Ramme, AP Terrasso, M Serra, PM Alves, C Brito, ... Journal of biotechnology 205, 36-46, 2015 | 175 | 2015 |
Bone marrow‐on‐a‐chip: Long‐term culture of human haematopoietic stem cells in a three‐dimensional microfluidic environment S Sieber, L Wirth, N Cavak, M Koenigsmark, U Marx, R Lauster, ... Journal of tissue engineering and regenerative medicine 12 (2), 479-489, 2018 | 168 | 2018 |
Non-animal models of epithelial barriers (skin, intestine and lung) in research, industrial applications and regulatory toxicology. S Gordon, M Daneshian, J Bouwstra, F Caloni, S Constant, DE Davies, ... Altex 32 (4), 327-378, 2015 | 167 | 2015 |
Chip-based liver equivalents for toxicity testing–organotypicalness versus cost-efficient high throughput EM Materne, AG Tonevitsky, U Marx Lab on a Chip 13 (18), 3481-3495, 2013 | 143 | 2013 |
A human lymph node in vitro—Challenges and progress C Giese, CD Demmler, R Ammer, S Hartmann, A Lubitz, L Miller, R Müller, ... Artificial organs 30 (10), 803-808, 2006 | 125 | 2006 |
Application of microphysiological systems to enhance safety assessment in drug discovery L Ewart, EM Dehne, K Fabre, S Gibbs, J Hickman, E Hornberg, ... Annual review of pharmacology and toxicology 58 (1), 65-82, 2018 | 121 | 2018 |
The multi-organ chip-a microfluidic platform for long-term multi-tissue coculture EM Materne, I Maschmeyer, AK Lorenz, R Horland, KMS Schimek, ... JoVE (Journal of Visualized Experiments), e52526, 2015 | 121 | 2015 |
Variable domain-linked oligosaccharides of a human monoclonal IgG: structure and influence on antigen binding H Leibiger, D WÜSTNER, RD STIGLER, U MARX Biochemical Journal 338 (2), 529-538, 1999 | 112 | 1999 |
Rapid flip-flop of phospholipids in endoplasmic reticulum membranes studied by a stopped-flow approach U Marx, G Lassmann, HG Holzhütter, D Wüstner, P Müller, A Höhlig, ... Biophysical journal 78 (5), 2628-2640, 2000 | 111 | 2000 |
Immunological substance testing on human lymphatic micro-organoids in vitro C Giese, A Lubitz, CD Demmler, J Reuschel, K Bergner, U Marx Journal of biotechnology 148 (1), 38-45, 2010 | 106 | 2010 |