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Ann-Hwee Lee
Ann-Hwee Lee
Verified email at regeneron.com
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Cited by
Year
Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes
U Ozcan, Q Cao, E Yilmaz, AH Lee, NN Iwakoshi, E Ozdelen, G Tuncman, ...
Science 306 (5695), 457-461, 2004
45442004
XBP-1 regulates a subset of endoplasmic reticulum resident chaperone genes in the unfolded protein response
AH Lee, NN Iwakoshi, LH Glimcher
Molecular and cellular biology 23 (21), 7448-7459, 2003
24612003
XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease
A Kaser, AH Lee, A Franke, JN Glickman, S Zeissig, H Tilg, ...
Cell 134 (5), 743-756, 2008
15732008
XBP1, downstream of Blimp-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiation
AL Shaffer, M Shapiro-Shelef, NN Iwakoshi, AH Lee, SB Qian, H Zhao, ...
Immunity 21 (1), 81-93, 2004
11952004
Regulation of hepatic lipogenesis by the transcription factor XBP1
AH Lee, EF Scapa, DE Cohen, LH Glimcher
Science 320 (5882), 1492-1496, 2008
11092008
Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1
NN Iwakoshi, AH Lee, P Vallabhajosyula, KL Otipoby, K Rajewsky, ...
Nature immunology 4 (4), 321-329, 2003
10552003
TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages
F Martinon, X Chen, AH Lee, LH Glimcher
Nature immunology 11 (5), 411-418, 2010
10192010
Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1α
C Hetz, P Bernasconi, J Fisher, AH Lee, MC Bassik, B Antonsson, ...
Science 312 (5773), 572-576, 2006
8102006
ER stress sensor XBP1 controls anti-tumor immunity by disrupting dendritic cell homeostasis
JR Cubillos-Ruiz, PC Silberman, MR Rutkowski, S Chopra, ...
Cell 161 (7), 1527-1538, 2015
7582015
The endoplasmic reticulum stress response in immunity and autoimmunity
DJ Todd, AH Lee, LH Glimcher
Nature reviews immunology 8 (9), 663-674, 2008
7262008
Proteasome inhibitors disrupt the unfolded protein response in myeloma cells
AH Lee, NN Iwakoshi, KC Anderson, LH Glimcher
Proceedings of the National Academy of Sciences 100 (17), 9946-9951, 2003
7242003
XBP1 is essential for survival under hypoxic conditions and is required for tumor growth
L Romero-Ramirez, H Cao, D Nelson, E Hammond, AH Lee, H Yoshida, ...
Cancer research 64 (17), 5943-5947, 2004
6832004
XBP‐1 is required for biogenesis of cellular secretory machinery of exocrine glands
AH Lee, GC Chu, NN Iwakoshi, LH Glimcher
The EMBO journal 24 (24), 4368-4380, 2005
5032005
Spliced X-box binding protein 1 couples the unfolded protein response to hexosamine biosynthetic pathway
ZV Wang, Y Deng, N Gao, Z Pedrozo, DL Li, CR Morales, A Criollo, X Luo, ...
Cell 156 (6), 1179-1192, 2014
3702014
The X‐box binding protein‐1 transcription factor is required for plasma cell differentiation and the unfolded protein response
NN Iwakoshi, AH Lee, LH Glimcher
Immunological reviews 194 (1), 29-38, 2003
3392003
Dual and opposing roles of the unfolded protein response regulated by IRE1α and XBP1 in proinsulin processing and insulin secretion
AH Lee, K Heidtman, GS Hotamisligil, LH Glimcher
Proceedings of the National Academy of Sciences 108 (21), 8885-8890, 2011
3152011
Transcriptional control of hepatic lipid metabolism by SREBP and ChREBP
X Xu, JS So, JG Park, AH Lee
Seminars in liver disease 33 (04), 301-311, 2013
2922013
Silencing of lipid metabolism genes through IRE1α-mediated mRNA decay lowers plasma lipids in mice
JS So, KY Hur, M Tarrio, V Ruda, M Frank-Kamenetsky, K Fitzgerald, ...
Cell metabolism 16 (4), 487-499, 2012
2862012
XBP1 governs late events in plasma cell differentiation and is not required for antigen-specific memory B cell development
DJ Todd, LJ McHeyzer-Williams, C Kowal, AH Lee, BT Volpe, B Diamond, ...
Journal of Experimental Medicine 206 (10), 2151-2159, 2009
2522009
The transcription factor cyclic AMP–responsive element–binding protein H regulates triglyceride metabolism
JH Lee, P Giannikopoulos, SA Duncan, J Wang, CT Johansen, JD Brown, ...
Nature medicine 17 (7), 812-815, 2011
2272011
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