| Safety and antitumor activity of anti–PD-1 antibody, nivolumab, in patients with platinum-resistant ovarian cancer J Hamanishi, M Mandai, T Ikeda, M Minami, A Kawaguchi, T Murayama, ... Journal of Clinical Oncology 33 (34), 4015-4022, 2015 | 1118 | 2015 |
| A rheostat for immune responses: the unique properties of PD-1 and their advantages for clinical application T Okazaki, S Chikuma, Y Iwai, S Fagarasan, T Honjo Nature immunology 14 (12), 1212-1218, 2013 | 1013 | 2013 |
| Brain regulatory T cells suppress astrogliosis and potentiate neurological recovery M Ito, K Komai, S Mise-Omata, M Iizuka-Koga, Y Noguchi, T Kondo, ... Nature 565 (7738), 246-250, 2019 | 514 | 2019 |
| CD44 variants but not CD44s cooperate with β1-containing integrins to permit cells to bind to osteopontin independently of arginine-glycine-aspartic acid, thereby stimulating … YU Katagiri, J Sleeman, H Fujii, P Herrlich, H Hotta, K Tanaka, S Chikuma, ... Cancer research 59 (1), 219-226, 1999 | 422 | 1999 |
| IFN-α directly promotes programmed cell death-1 transcription and limits the duration of T cell-mediated immunity S Terawaki, S Chikuma, S Shibayama, T Hayashi, T Yoshida, T Okazaki, ... The Journal of Immunology 186 (5), 2772-2779, 2011 | 379 | 2011 |
| PD-1 deficiency results in the development of fatal myocarditis in MRL mice J Wang, I Okazaki, T Yoshida, S Chikuma, Y Kato, F Nakaki, H Hiai, ... International immunology 22 (6), 443-452, 2010 | 268 | 2010 |
| PD-1-mediated suppression of IL-2 production induces CD8+ T cell anergy in vivo S Chikuma, S Terawaki, T Hayashi, R Nabeshima, T Yoshida, ... The Journal of Immunology 182 (11), 6682-6689, 2009 | 238 | 2009 |
| Chemokine-dependent T cell migration requires aquaporin-3–mediated hydrogen peroxide uptake M Hara-Chikuma, S Chikuma, Y Sugiyama, K Kabashima, AS Verkman, ... Journal of Experimental Medicine 209 (10), 1743-1752, 2012 | 201 | 2012 |
| Blockage of core fucosylation reduces cell-surface expression of PD-1 and promotes anti-tumor immune responses of T cells M Okada, S Chikuma, T Kondo, S Hibino, H Machiyama, T Yokosuka, ... Cell reports 20 (5), 1017-1028, 2017 | 181 | 2017 |
| Negative regulation of cytokine signaling in immunity A Yoshimura, M Ito, S Chikuma, T Akanuma, H Nakatsukasa Cold Spring Harbor perspectives in biology 10 (7), a028571, 2018 | 174 | 2018 |
| Negative regulation of t cell receptor–lipid raft interaction by cytotoxic t lymphocyte–associated antigen 4 S Chikuma, JB Imboden, JA Bluestone The Journal of experimental medicine 197 (1), 129-135, 2003 | 166 | 2003 |
| Nonoverlapping roles of PD-1 and FoxP3 in maintaining immune tolerance in a novel autoimmune pancreatitis mouse model B Zhang, S Chikuma, S Hori, S Fagarasan, T Honjo Proceedings of the National Academy of Sciences 113 (30), 8490-8495, 2016 | 159 | 2016 |
| CTLA-4, an essential immune-checkpoint for T-cell activation S Chikuma Emerging Concepts Targeting Immune Checkpoints in Cancer and Autoimmunity …, 2017 | 151 | 2017 |
| Suppressors of cytokine signaling: potential immune checkpoint molecules for cancer immunotherapy S Chikuma, M Kanamori, S Mise‐Omata, A Yoshimura Cancer science 108 (4), 574-580, 2017 | 116 | 2017 |
| Antibodies to different peptides in osteopontin reveal complexities in the various secreted forms S Kon, M Maeda, T Segawa, Y Hagiwara, Y Horikoshi, S Chikuma, ... Journal of cellular biochemistry 77 (3), 487-498, 2000 | 114 | 2000 |
| TRIM28 prevents autoinflammatory T cell development in vivo S Chikuma, N Suita, IM Okazaki, S Shibayama, T Honjo Nature immunology 13 (6), 596-603, 2012 | 113 | 2012 |
| Notch-mediated conversion of activated T cells into stem cell memory-like T cells for adoptive immunotherapy T Kondo, R Morita, Y Okuzono, H Nakatsukasa, T Sekiya, S Chikuma, ... Nature communications 8 (1), 15338, 2017 | 106 | 2017 |
| B7-independent inhibition of T cells by CTLA-4 S Chikuma, AK Abbas, JA Bluestone The Journal of Immunology 175 (1), 177-181, 2005 | 104 | 2005 |
| Basics of PD-1 in self-tolerance, infection, and cancer immunity S Chikuma International journal of clinical oncology 21, 448-455, 2016 | 92 | 2016 |
| CTLA-4 and tolerance: the biochemical point of view S Chikuma, JA Bluestone Immunologic research 28 (3), 241-253, 2003 | 91 | 2003 |
