Heterogeneity of neuroblastoma cell identity defined by transcriptional circuitries V Boeva, C Louis-Brennetot, A Peltier, S Durand, C Pierre-Eugène, ... Nature genetics 49 (9), 1408-1413, 2017 | 405 | 2017 |
Evidence for an alternative fatty acid desaturation pathway increasing cancer plasticity K Vriens, S Christen, S Parik, D Broekaert, K Yoshinaga, A Talebi, ... Nature 566 (7744), 403-406, 2019 | 365 | 2019 |
Proline metabolism supports metastasis formation and could be inhibited to selectively target metastasizing cancer cells I Elia, D Broekaert, S Christen, R Boon, E Radaelli, MF Orth, C Verfaillie, ... Nature communications 8 (1), 15267, 2017 | 337 | 2017 |
Breast cancer-derived lung metastases show increased pyruvate carboxylase-dependent anaplerosis S Christen, D Lorendeau, R Schmieder, D Broekaert, K Metzger, K Veys, ... Cell reports 17 (3), 837-848, 2016 | 227 | 2016 |
Eukaryotic initiation factor 4E-binding protein 1 (4E-BP1): a master regulator of mRNA translation involved in tumorigenesis J Musa, MF Orth, M Dallmayer, M Baldauf, C Pardo, B Rotblat, T Kirchner, ... Oncogene 35 (36), 4675-4688, 2016 | 161 | 2016 |
PHGDH heterogeneity potentiates cancer cell dissemination and metastasis M Rossi, P Altea-Manzano, M Demicco, G Doglioni, L Bornes, M Fukano, ... Nature 605 (7911), 747-753, 2022 | 95 | 2022 |
An update on the LIM and SH3 domain protein 1 (LASP1): a versatile structural, signaling, and biomarker protein MF Orth, A Cazes, E Butt, TGP Grunewald Oncotarget 6 (1), 26, 2015 | 83 | 2015 |
Robust diagnosis of Ewing sarcoma by immunohistochemical detection of super-enhancer-driven EWSR1-ETS targets MC Baldauf, MF Orth, M Dallmayer, A Marchetto, JS Gerke, RA Rubio, ... Oncotarget 9 (2), 1587, 2018 | 82 | 2018 |
Loss of tumor suppressor mir-203 mediates overexpression of LIM and SH3 Protein 1 (LASP1) in high-risk prostate cancer thereby increasing cell proliferation and migration A Hailer, TGP Grunewald, M Orth, C Reiss, B Kneitz, M Spahn, E Butt Oncotarget 5 (12), 4144, 2014 | 74 | 2014 |
Cooperation of cancer drivers with regulatory germline variants shapes clinical outcomes J Musa, F Cidre-Aranaz, MM Aynaud, MF Orth, MML Knott, O Mirabeau, ... Nature communications 10 (1), 4128, 2019 | 58 | 2019 |
Regulation of matrix metalloproteinases (MMPs) expression and secretion in MDA-MB-231 breast cancer cells by LIM and SH3 protein 1 (LASP1) M Endres, S Kneitz, MF Orth, RK Perera, A Zernecke, E Butt Oncotarget 7 (39), 64244, 2016 | 57 | 2016 |
mTOR signaling and SREBP activity increase FADS2 expression and can activate sapienate biosynthesis M Triki, G Rinaldi, M Planque, D Broekaert, AM Winkelkotte, CR Maier, ... Cell reports 31 (12), 2020 | 48 | 2020 |
A comparative view on the expression patterns of PD-L1 and PD-1 in soft tissue sarcomas MF Orth, VL Buecklein, E Kampmann, M Subklewe, E Noessner, ... Cancer Immunology, Immunotherapy 69, 1353-1362, 2020 | 44 | 2020 |
Oncogenic hijacking of a developmental transcription factor evokes vulnerability toward oxidative stress in Ewing sarcoma A Marchetto, S Ohmura, MF Orth, MML Knott, MV Colombo, C Arrigoni, ... Nature communications 11 (1), 2423, 2020 | 40 | 2020 |
Gene expression and immunohistochemical analyses identify SOX2 as major risk factor for overall survival and relapse in Ewing sarcoma patients G Sannino, A Marchetto, A Ranft, S Jabar, C Zacherl, R Alba-Rubio, ... EBioMedicine 47, 156-162, 2019 | 28 | 2019 |
Translational evidence for RRM2 as a prognostic biomarker and therapeutic target in Ewing sarcoma S Ohmura, A Marchetto, MF Orth, J Li, S Jabar, A Ranft, E Vinca, ... Molecular Cancer 20, 1-7, 2021 | 27 | 2021 |
Targeting the CALCB/RAMP1 axis inhibits growth of Ewing sarcoma M Dallmayer, J Li, S Ohmura, R Alba Rubio, MC Baldauf, TLB Hölting, ... Cell death & disease 10 (2), 116, 2019 | 26 | 2019 |
Are EWSR1-NFATc2-positive sarcomas really Ewing sarcomas? MC Baldauf, JS Gerke, MF Orth, M Dallmayer, D Baumhoer, E de Alava, ... Modern Pathology 31 (6), 997-999, 2018 | 24 | 2018 |
Systematic multi-omics cell line profiling uncovers principles of Ewing sarcoma fusion oncogene-mediated gene regulation MF Orth, D Surdez, T Faehling, AC Ehlers, A Marchetto, S Grossetête, ... Cell reports 41 (10), 2022 | 23 | 2022 |
Systematic identification of cancer-specific MHC-binding peptides with RAVEN MC Baldauf, JS Gerke, A Kirschner, F Blaeschke, M Effenberger, ... Oncoimmunology 7 (9), e1481558, 2018 | 22 | 2018 |