Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPase J Deng, PA Lewis, E Greggio, E Sluch, A Beilina, MR Cookson Proceedings of the National Academy of Sciences 105 (5), 1499-1504, 2008 | 278 | 2008 |
Crystal structure of Manduca sexta prophenoloxidase provides insights into the mechanism of type 3 copper enzymes Y Li, Y Wang, H Jiang, J Deng Proceedings of the National Academy of Sciences 106 (40), 17002-17006, 2009 | 193 | 2009 |
The Parkinson’s disease kinase LRRK2 autophosphorylates its GTPase domain at multiple sites E Greggio, JM Taymans, EY Zhen, J Ryder, R Vancraenenbroeck, ... Biochemical and biophysical research communications 389 (3), 449-454, 2009 | 191 | 2009 |
X-ray analysis of an RNA tetraplex (UGGGGU)4 with divalent Sr2+ ions at subatomic resolution (0.61 Å) J Deng, Y Xiong, M Sundaralingam Proceedings of the National Academy of Sciences 98 (24), 13665-13670, 2001 | 188 | 2001 |
Structural biology of the IL‐1 superfamily: Key cytokines in the regulation of immune and inflammatory responses B Krumm, Y Xiang, J Deng Protein Science 23 (5), 526-538, 2014 | 104 | 2014 |
Structure-guided design of an Hsp90β N-terminal isoform-selective inhibitor A Khandelwal, CN Kent, M Balch, S Peng, SJ Mishra, J Deng, VW Day, ... Nature communications 9 (1), 425, 2018 | 103 | 2018 |
An improved protocol for rapid freezing of protein samples for long-term storage J Deng, DR Davies, G Wisedchaisri, M Wu, WGJ Hol, C Mehlin Acta Crystallographica Section D: Biological Crystallography 60 (1), 203-204, 2004 | 101 | 2004 |
Crystal structure of an RNA purine-rich tetraplex containing adenine tetrads: implications for specific binding in RNA tetraplexes B Pan, Y Xiong, K Shi, J Deng, M Sundaralingam Structure 11 (7), 815-823, 2003 | 97 | 2003 |
High resolution crystal structure of a key editosome enzyme from Trypanosoma brucei: RNA editing ligase 1 J Deng, A Schnaufer, R Salavati, KD Stuart, WGJ Hol Journal of molecular biology 343 (3), 601-613, 2004 | 87 | 2004 |
Structural basis for antagonism of human interleukin 18 by poxvirus interleukin 18-binding protein B Krumm, X Meng, Y Li, Y Xiang, J Deng Proceedings of the National Academy of Sciences 105 (52), 20711-20715, 2008 | 84 | 2008 |
Structural basis for UTP specificity of RNA editing TUTases from Trypanosoma brucei J Deng, NL Ernst, S Turley, KD Stuart, WGJ Hol The EMBO journal 24 (23), 4007-4017, 2005 | 83 | 2005 |
The R1441C mutation alters the folding properties of the ROC domain of LRRK2 Y Li, L Dunn, E Greggio, B Krumm, GS Jackson, MR Cookson, PA Lewis, ... Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1792 (12 …, 2009 | 62 | 2009 |
A protein-protein interaction map of trypanosome∼ 20S editosomes A Schnaufer, M Wu, Y Park, T Nakai, J Deng, R Proff, WGJ Hol, KD Stuart Journal of biological chemistry 285 (8), 5282-5295, 2010 | 58 | 2010 |
A CC′ loop decoy peptide blocks the interaction between Act1 and IL-17RA to attenuate IL-17–and IL-25–induced inflammation C Liu, S Swaidani, W Qian, Z Kang, P Sun, Y Han, C Wang, MF Gulen, ... Science signaling 4 (197), ra72-ra72, 2011 | 56 | 2011 |
KREPA6 is an RNA-binding protein essential for editosome integrity and survival of Trypanosoma brucei SZ Tarun, A Schnaufer, NL Ernst, R Proff, J Deng, W Hol, K Stuart Rna 14 (2), 347-358, 2008 | 47 | 2008 |
Structure of the unique SEFIR domain from human interleukin 17 receptor A reveals a composite ligand-binding site containing a conserved α-helix for Act1 binding and IL-17 … B Zhang, C Liu, W Qian, Y Han, X Li, J Deng Acta Crystallographica Section D: Biological Crystallography 70 (5), 1476-1483, 2014 | 43 | 2014 |
Selective inhibition of the Hsp90α isoform SJ Mishra, A Khandelwal, M Banerjee, M Balch, S Peng, RE Davis, ... Angewandte Chemie International Edition 60 (19), 10547-10551, 2021 | 39 | 2021 |
Energetic coupling between an oxidizable cysteine and the phosphorylatable N-terminus of human liver pyruvate kinase T Holyoak, B Zhang, J Deng, Q Tang, CB Prasannan, AW Fenton Biochemistry 52 (3), 466-476, 2013 | 39 | 2013 |
Structure function studies of vaccinia virus host range protein k1 reveal a novel functional surface for ankyrin repeat proteins Y Li, X Meng, Y Xiang, J Deng Journal of virology 84 (7), 3331-3338, 2010 | 38 | 2010 |
The structure of a prophenoloxidase (PPO) from Anopheles gambiae provides new insights into the mechanism of PPO activation Y Hu, Y Wang, J Deng, H Jiang BMC biology 14, 1-13, 2016 | 35 | 2016 |