Greg Brooke
Greg Brooke
Senior Lecturer in Molecular and Cellular Biology, University of Essex
Verified email at - Homepage
Cited by
Cited by
The role of androgen receptor mutations in prostate cancer progression
GN Brooke, CL Bevan
Current genomics 10 (1), 18-25, 2009
Gliotoxin is a dual inhibitor of farnesyltransferase and geranylgeranyltransferase I with antitumor activity against breast cancer in vivo
DM Vigushin, N Mirsaidi, G Brooke, C Sun, P Pace, L Inman, CJ Moody, ...
Medical oncology 21, 21-30, 2004
Revising the role of the androgen receptor in breast cancer
FM Fioretti, A Sita-Lumsden, CL Bevan, GN Brooke
Journal of molecular endocrinology 52 (3), R257-R265, 2014
Prohibitin, a protein downregulated by androgens, represses androgen receptor activity
SC Gamble, D Chotai, M Odontiadis, DA Dart, GN Brooke, SM Powell, ...
Oncogene 26 (12), 1757-1768, 2007
Mechanisms of androgen receptor activation in advanced prostate cancer: differential co-activator recruitment and gene expression
GN Brooke, MG Parker, CL Bevan
Oncogene 27 (21), 2941-2950, 2008
The antiandrogen enzalutamide downregulates TMPRSS2 and reduces cellular entry of SARS-CoV-2 in human lung cells
DA Leach, A Mohr, ES Giotis, E Cil, AM Isac, LL Yates, WS Barclay, ...
Nature Communications 12 (1), 4068, 2021
Allosteric conversation in the androgen receptor ligand-binding domain surfaces
S Grosdidier, LR Carbó, V Buzón, G Brooke, P Nguyen, JD Baxter, ...
Molecular Endocrinology 26 (7), 1078-1090, 2012
FUS/TLS is a novel mediator of androgen-dependent cell-cycle progression and prostate cancer growth
GN Brooke, RL Culley, DA Dart, DJ Mann, L Gaughan, SR McCracken, ...
Cancer research 71 (3), 914-924, 2011
Structural and functional modelling of SARS-CoV-2 entry in animal models
GN Brooke, F Prischi
Scientific reports 10 (1), 15917, 2020
Role of the HSP90-associated cochaperone p23 in enhancing activity of the androgen receptor and significance for prostate cancer
V Reebye, L Querol Cano, DN Lavery, GN Brooke, SM Powell, D Chotai, ...
Molecular endocrinology 26 (10), 1694-1706, 2012
The co-chaperone p23 promotes prostate cancer motility and metastasis
LQ Cano, DN Lavery, S Sin, E Spanjaard, GN Brooke, JD Tilman, ...
Molecular oncology 9 (1), 295-308, 2015
Reducing prohibitin increases histone acetylation, and promotes androgen independence in prostate tumours by increasing androgen receptor activation by adrenal androgens
DA Dart, GN Brooke, A Sita-Lumsden, J Waxman, CL Bevan
Oncogene 31 (43), 4588-4598, 2012
Circulating nucleic acids as biomarkers of prostate cancer
A Sita-Lumsden, CE Fletcher, DA Dart, GN Brooke, J Waxman, CL Bevan
Biomarkers in medicine 7 (6), 867-877, 2013
Pyrazino [1, 2-a] indole-1, 4-diones, simple analogues of gliotoxin, as selective inhibitors of geranylgeranyltransferase I
DM Vigushin, G Brooke, D Willows, RC Coombes, CJ Moody
Bioorganic & medicinal chemistry letters 13 (21), 3661-3663, 2003
The role of the p90 ribosomal S6 kinase family in prostate cancer progression and therapy resistance
R Cronin, GN Brooke, F Prischi
Oncogene 40 (22), 3775-3785, 2021
MSC. sTRAIL has better efficacy than MSC. FL-TRAIL and in combination with AKTi blocks pro-metastatic cytokine production in prostate cancer cells
A Mohr, T Chu, GN Brooke, RM Zwacka
Cancers 11 (4), 568, 2019
Characterisation of the androgen regulation of glycine N-methyltransferase in prostate cancer cells
S Ottaviani, GN Brooke, C O'Hanlon-Brown, J Waxman, S Ali, L Buluwela
Journal of molecular endocrinology 51 (3), 301-312, 2013
Mechanisms of androgen receptor repression in prostate cancer
SM Powell, GN Brooke, HC Whitaker, V Reebye, SC Gamble, D Chotai, ...
Biochemical Society Transactions 34 (6), 1124-1127, 2006
Antiandrogens Act as Selective Androgen Receptor Modulators at the Proteome Level in Prostate Cancer Cells*[S]
GN Brooke, SC Gamble, MA Hough, S Begum, DA Dart, M Odontiadis, ...
Molecular & Cellular Proteomics 14 (5), 1201-1216, 2015
Cyclic acid anhydrides as a new class of potent, selective and non-peptidic inhibitors of geranylgeranyl transferase
CM Marson, AS Rioja, G Brooke, RC Coombes, DM Vigushin
Bioorganic & medicinal chemistry letters 12 (2), 255-259, 2002
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