Hema Viswambharan
Hema Viswambharan
Division of Cardiovascular and Diabetes Research, LICAMM, University of Leeds
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Rho GTPase/Rho kinase negatively regulates endothelial nitric oxide synthase phosphorylation through the inhibition of protein kinase B/Akt in human endothelial cells
XF Ming, H Viswambharan, C Barandier, J Ruffieux, K Kaibuchi, ...
Molecular and cellular biology 22 (24), 8467-8477, 2002
Thrombin stimulates human endothelial arginase enzymatic activity via RhoA/ROCK pathway: implications for atherosclerotic endothelial dysfunction
XF Ming, C Barandier, H Viswambharan, BR Kwak, F Mach, L Mazzolai, ...
Circulation 110 (24), 3708-3714, 2004
Mutation of the Circadian Clock Gene Per2 Alters Vascular Endothelial Function
H Viswambharan, JM Carvas, V Antic, A Marecic, C Jud, CE Zaugg, ...
Circulation 115 (16), 2188-2195, 2007
Piezo1 channels sense whole body physical activity to reset cardiovascular homeostasis and enhance performance
B Rode, J Shi, N Endesh, MJ Drinkhill, PJ Webster, SJ Lotteau, MA Bailey, ...
Nature communications 8 (1), 350, 2017
Endothelial-specific deletion of connexin40 promotes atherosclerosis by increasing CD73-dependent leukocyte adhesion
CE Chadjichristos, KEL Scheckenbach, TB Van Veen, ...
Circulation 121 (1), 123-131, 2010
Reconstituted high-density lipoprotein inhibits thrombin-induced endothelial tissue factor expression through inhibition of RhoA and stimulation of phosphatidylinositol 3 …
H Viswambharan, XF Ming, S Zhu, A Hubsch, P Lerch, G Vergčres, ...
Circulation research 94 (7), 918-925, 2004
Nox2 NADPH oxidase has a critical role in insulin resistance–related endothelial cell dysfunction
P Sukumar, H Viswambharan, H Imrie, RM Cubbon, N Yuldasheva, ...
Diabetes 62 (6), 2130-2134, 2013
HMG-CoA reductase inhibition improves endothelial cell function and inhibits smooth muscle cell proliferation in human saphenous veins
Z Yang, T Kozai, B van de Loo, H Viswambharan, M Lachat, MI Turina, ...
Journal of the American College of Cardiology 36 (5), 1691-1697, 2000
Increasing circulating IGFBP1 levels improves insulin sensitivity, promotes nitric oxide production, lowers blood pressure, and protects against atherosclerosis
A Rajwani, V Ezzat, J Smith, NY Yuldasheva, ER Duncan, M Gage, ...
Diabetes 61 (4), 915-924, 2012
The insulin-like growth factor-1 receptor is a negative regulator of nitric oxide bioavailability and insulin sensitivity in the endothelium
A Abbas, H Imrie, H Viswambharan, P Sukumar, A Rajwani, RM Cubbon, ...
Diabetes 60 (8), 2169-2178, 2011
Insulin resistance impairs circulating angiogenic progenitor cell function and delays endothelial regeneration
MB Kahn, NY Yuldasheva, RM Cubbon, J Smith, ST Rashid, ...
Diabetes 60 (4), 1295-1303, 2011
Endothelium-specific insulin resistance leads to accelerated atherosclerosis in areas with disturbed flow patterns: a role for reactive oxygen species
MC Gage, NY Yuldasheva, H Viswambharan, P Sukumar, RM Cubbon, ...
Atherosclerosis 230 (1), 131-139, 2013
Novel role of the IGF-1 receptor in endothelial function and repair: studies in endothelium-targeted IGF-1 receptor transgenic mice
H Imrie, H Viswambharan, P Sukumar, A Abbas, RM Cubbon, ...
Diabetes 61 (9), 2359-2368, 2012
Vascular insulin-like growth factor-I resistance and diet-induced obesity
H Imrie, A Abbas, H Viswambharan, A Rajwani, RM Cubbon, M Gage, ...
Endocrinology 150 (10), 4575-4582, 2009
Insulin-like growth factor binding protein 1 could improve glucose regulation and insulin sensitivity through its RGD domain
NJ Haywood, PA Cordell, KY Tang, N Makova, NY Yuldasheva, H Imrie, ...
Diabetes 66 (2), 287-299, 2017
Selective enhancement of insulin sensitivity in the endothelium in vivo reveals a novel proatherosclerotic signaling loop
H Viswambharan, NY Yuldasheva, A Sengupta, H Imrie, MC Gage, ...
Circulation research 120 (5), 784-798, 2017
Endothelial nitric oxide synthase gene transfer restores endothelium–dependent relaxations and attenuates lesion formation in carotid arteries in apolipoprotein E–deficient mice
K Mujynya–Ludunge, H Viswambharan, R Driscoll, XF Ming, ...
Basic research in cardiology 100, 102-111, 2005
Piezo1 channel activation mimics high glucose as a stimulator of insulin release
V Deivasikamani, S Dhayalan, Y Abudushalamu, R Mughal, A Visnagri, ...
Scientific reports 9 (1), 16876, 2019
Thrombin activates the p21-activated kinase in pulmonary artery smooth muscle cells
A Görlach, RS BelAiba, J Hess, T Kietzmann
Thrombosis and haemostasis 93 (06), 1168-1175, 2005
Endothelial SHIP2 Suppresses Nox2 NADPH Oxidase–Dependent Vascular Oxidative Stress, Endothelial Dysfunction, and Systemic Insulin Resistance
NT Watt, MC Gage, PA Patel, H Viswambharan, P Sukumar, S Galloway, ...
Diabetes 66 (11), 2808-2821, 2017
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