Adam P Sharples
Adam P Sharples
Professor of Epigenetics and Molecular Physiology
Verified email at - Homepage
Cited by
Cited by
Human skeletal muscle possesses an epigenetic memory of hypertrophy
RA Seaborne, J Strauss, M Cocks, S Shepherd, TD O’Brien, ...
Scientific reports 8 (1), 1898, 2018
Longevity and skeletal muscle mass: the role of IGF signalling, the sirtuins, dietary restriction and protein intake
AP Sharples, DC Hughes, CS Deane, A Saini, C Selman, CE Stewart
Aging cell 14 (4), 511-523, 2015
Does skeletal muscle have an ‘epi’‐memory? The role of epigenetics in nutritional programming, metabolic disease, aging and exercise
AP Sharples, CE Stewart, RA Seaborne
Aging cell 15 (4), 603-616, 2016
A systems-based investigation into vitamin D and skeletal muscle repair, regeneration, and hypertrophy
DJ Owens, AP Sharples, I Polydorou, N Alwan, T Donovan, J Tang, ...
American Journal of Physiology-Endocrinology and Metabolism, 2015
Fuel for the work required: a practical approach to amalgamating train‐low paradigms for endurance athletes
SG Impey, KM Hammond, SO Shepherd, AP Sharples, C Stewart, M Limb, ...
Physiological reports 4 (10), e12803, 2016
Comparative transcriptome and methylome analysis in human skeletal muscle anabolism, hypertrophy and epigenetic memory
DC Turner, RA Seaborne, AP Sharples
Scientific reports 9 (1), 4251, 2019
Factors affecting the structure and maturation of human tissue engineered skeletal muscle
NRW Martin, SL Passey, DJ Player, A Khodabukus, RA Ferguson, ...
Biomaterials 34 (23), 5759-5765, 2013
DNA methylation across the genome in aged human skeletal muscle tissue and muscle-derived cells: the role of HOX genes and physical activity
DC Turner, PP Gorski, MF Maasar, RA Seaborne, P Baumert, AD Brown, ...
Scientific Reports 10 (1), 15360, 2020
Modelling in vivo skeletal muscle ageing in vitro using three‐dimensional bioengineered constructs
AP Sharples, DJ Player, NRW Martin, V Mudera, CE Stewart, MP Lewis
Aging cell 11 (6), 986-995, 2012
An epigenetic clock for human skeletal muscle
S Voisin, NR Harvey, LM Haupt, LR Griffiths, KJ Ashton, VG Coffey, ...
Journal of cachexia, sarcopenia and muscle 11 (4), 887-898, 2020
Molecular responses to acute exercise and their relevance for adaptations in skeletal muscle to exercise training
B Egan, AP Sharples
Physiological Reviews, 2023
Methylome of human skeletal muscle after acute & chronic resistance exercise training, detraining & retraining
RA Seaborne, J Strauss, M Cocks, S Shepherd, TD O’brien, ...
Scientific data 5 (1), 1-9, 2018
C2 and C2C12 murine skeletal myoblast models of atrophic and hypertrophic potential: Relevance to disease and ageing?
AP Sharples, N Al‐Shanti, CE Stewart
Journal of cellular physiology 225 (1), 240-250, 2010
Skeletal muscle cells possess a ‘memory’of acute early life TNF-α exposure: role of epigenetic adaptation
AP Sharples, I Polydorou, DC Hughes, DJ Owens, TM Hughes, ...
Biogerontology 17, 603-617, 2016
The interplay between exercise metabolism, epigenetics, and skeletal muscle remodeling
RA Seaborne, AP Sharples
Exercise and sport sciences reviews 48 (4), 188-200, 2020
UBR5 is a novel E3 ubiquitin ligase involved in skeletal muscle hypertrophy and recovery from atrophy
RA Seaborne, DC Hughes, DC Turner, DJ Owens, LM Baehr, P Gorski, ...
The Journal of physiology 597 (14), 3727-3749, 2019
Reduction of myoblast differentiation following multiple population doublings in mouse C2C12 cells: A model to investigate ageing?
AP Sharples, N Al‐Shanti, MP Lewis, CE Stewart
Journal of cellular biochemistry 112 (12), 3773-3785, 2011
Post‐exercise carbohydrate and energy availability induce independent effects on skeletal muscle cell signalling and bone turnover: implications for training adaptation
KM Hammond, C Sale, W Fraser, J Tang, SO Shepherd, JA Strauss, ...
The Journal of physiology 597 (18), 4779-4796, 2019
Transcriptomic and epigenetic regulation of disuse atrophy and the return to activity in skeletal muscle
A Fisher, RA Seaborne, TM Hughes, A Gutteridge, CE Stewart, ...
FASEB journal, 2017
Testosterone enables growth and hypertrophy in fusion impaired myoblasts that display myotube atrophy: deciphering the role of androgen and IGF-I receptors
DC Hughes, CE Stewart, N Sculthorpe, HF Dugdale, F Yousefian, ...
Biogerontology 17, 619-639, 2016
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