| The p66shc adaptor protein controls oxidative stress response and life span in mammals E Migliaccio, M Giorgio, S Mele, G Pelicci, P Reboldi, PP Pandolfi, ... Nature 402 (6759), 309-313, 1999 | 2084 | 1999 |
| Hydrogen peroxide: a metabolic by-product or a common mediator of ageing signals? M Giorgio, M Trinei, E Migliaccio, PG Pelicci Nature reviews Molecular cell biology 8 (9), 722-728, 2007 | 1617 | 2007 |
| Electron transfer between cytochrome c and p66Shc generates reactive oxygen species that trigger mitochondrial apoptosis M Giorgio, E Migliaccio, F Orsini, D Paolucci, M Moroni, C Contursi, ... Cell 122 (2), 221-233, 2005 | 1302 | 2005 |
| Enrichment of tomato fruit with health-promoting anthocyanins by expression of select transcription factors E Butelli, L Titta, M Giorgio, HP Mock, A Matros, S Peterek, ... Nature biotechnology 26 (11), 1301-1308, 2008 | 1274 | 2008 |
| Role of PML in cell growth and the retinoic acid pathway Z Gang Wang, L Delva, M Gaboli, R Rivi, M Giorgio, C Cordon-Cardo, ... Science 279 (5356), 1547-1551, 1998 | 669 | 1998 |
| Protein kinase C ß and prolyl isomerase 1 regulate mitochondrial effects of the life-span determinant p66Shc P Pinton, A Rimessi, S Marchi, F Orsini, E Migliaccio, M Giorgio, ... Science 315 (5812), 659-663, 2007 | 577 | 2007 |
| A p53-p66Shc signalling pathway controls intracellular redox status, levels of oxidation-damaged DNA and oxidative stress-induced apoptosis M Trinei, M Giorgio, A Cicalese, S Barozzi, A Ventura, E Migliaccio, ... Oncogene 21 (24), 3872-3878, 2002 | 533 | 2002 |
| Deletion of the p66Shc longevity gene reduces systemic and tissue oxidative stress, vascular cell apoptosis, and early atherogenesis in mice fed a high-fat diet C Napoli, I Martin-Padura, F de Nigris, M Giorgio, G Mansueto, P Somma, ... Proceedings of the National Academy of Sciences 100 (4), 2112-2116, 2003 | 453 | 2003 |
| Diabetes Promotes Cardiac Stem Cell Aging and Heart Failure, Which Are Prevented by Deletion of the p66shc Gene M Rota, N LeCapitaine, T Hosoda, A Boni, A De Angelis, ... Circulation research 99 (1), 42-52, 2006 | 415 | 2006 |
| The life span determinant p66Shc localizes to mitochondria where it associates with mitochondrial heat shock protein 70 and regulates trans-membrane potential F Orsini, E Migliaccio, M Moroni, C Contursi, VA Raker, D Piccini, ... Journal of Biological Chemistry 279 (24), 25689-25695, 2004 | 346 | 2004 |
| Deletion of p66Shc longevity gene protects against experimental diabetic glomerulopathy by preventing diabetes-induced oxidative stress S Menini, L Amadio, G Oddi, C Ricci, C Pesce, F Pugliese, M Giorgio, ... Diabetes 55 (6), 1642-1650, 2006 | 225 | 2006 |
| Mitochondrial pathways for ROS formation and myocardial injury: the relevance of p66Shc and monoamine oxidase F Di Lisa, N Kaludercic, A Carpi, R Menabò, M Giorgio Basic research in cardiology 104, 131-139, 2009 | 208 | 2009 |
| Blood orange juice inhibits fat accumulation in mice L Titta, M Trinei, M Stendardo, I Berniakovich, K Petroni, C Tonelli, P Riso, ... International Journal of Obesity 34 (3), 578-588, 2010 | 197 | 2010 |
| p66Shc-generated Oxidative Signal Promotes Fat Accumulation∗ I Berniakovich, M Trinei, M Stendardo, E Migliaccio, S Minucci, P Bernardi, ... Journal of Biological Chemistry 283 (49), 34283-34293, 2008 | 192 | 2008 |
| A family of Shc related proteins with conserved PTB, CH1 and SH2 regions. G Pelicci, L Dente, A De Giuseppe, B Verducci-Galletti, S Giuli, S Mele, ... Oncogene 13 (3), 633-641, 1996 | 189 | 1996 |
| The cardioprotective effects elicited by p66Shc ablation demonstrate the crucial role of mitochondrial ROS formation in ischemia/reperfusion injury A Carpi, R Menabò, N Kaludercic, PG Pelicci, F Di Lisa, M Giorgio Biochimica et Biophysica Acta (BBA)-Bioenergetics 1787 (7), 774-780, 2009 | 180 | 2009 |
| Development of progressive kidney damage and myeloma kidney in interleukin-6 transgenic mice E Fattori, C Della Rocca, P Costa, M Giorgio, B Dente, L Pozzi, G Ciliberto | 158 | 1994 |
| Oxidative stress activates a specific p53 transcriptional response that regulates cellular senescence and aging V Gambino, G De Michele, O Venezia, P Migliaccio, V Dall'Olio, L Bernard, ... Aging cell 12 (3), 435-445, 2013 | 154 | 2013 |
| A cell- and developmental stage-specific promoter drives the expression of a truncated c-kit protein during mouse spermatid elongation C Albanesi, R Geremia, M Giorgio, S Dolci, C Sette, P Rossi Development 122 (4), 1291-1302, 1996 | 154 | 1996 |
| Apoptosis and Aging: Role of p66Shc Redox Protein E Migliaccio, M Giorgio, PG Pelicci Antioxidants & redox signaling 8 (3-4), 600-608, 2006 | 151 | 2006 |
