Ian Barrett
Ian Barrett
Verified email at astrazeneca.com
Cited by
Cited by
The DNA sequence of the human X chromosome
MT Ross, DV Grafham, AJ Coffey, S Scherer, K McLay, D Muzny, ...
Nature 434 (7031), 325-337, 2005
Drug screening in human PSC-cardiac organoids identifies pro-proliferative compounds acting via the mevalonate pathway
RJ Mills, BL Parker, GA Quaife-Ryan, HK Voges, EJ Needham, A Bornot, ...
Cell stem cell 24 (6), 895-907. e6, 2019
The brain-penetrant clinical ATM inhibitor AZD1390 radiosensitizes and improves survival of preclinical brain tumor models
ST Durant, L Zheng, Y Wang, K Chen, L Zhang, T Zhang, Z Yang, ...
Science advances 4 (6), eaat1719, 2018
Understanding cytotoxicity and cytostaticity in a high-throughput screening collection
LH Mervin, Q Cao, IP Barrett, MA Firth, D Murray, L McWilliams, ...
ACS chemical biology 11 (11), 3007-3023, 2016
Orthologue chemical space and its influence on target prediction
LH Mervin, KC Bulusu, L Kalash, AM Afzal, F Svensson, MA Firth, I Barrett, ...
Bioinformatics 34 (1), 72-79, 2018
Orally bioavailable and blood–brain barrier-penetrating ATM inhibitor (AZ32) radiosensitizes intracranial gliomas in mice
J Karlin, J Allen, SF Ahmad, G Hughes, V Sheridan, R Odedra, ...
Molecular cancer therapeutics 17 (8), 1637-1647, 2018
A mathematical model of antibody-dependent cellular cytotoxicity (ADCC)
F Hoffman, D Gavaghan, J Osborne, IP Barrett, T You, H Ghadially, ...
Journal of theoretical biology 436, 39-50, 2018
Automatic extraction of angiogenesis bioprocess from text
X Wang, I McKendrick, I Barrett, I Dix, T French, J Tsujii, S Ananiadou
Bioinformatics 27 (19), 2730-2737, 2011
Discovery of retinoic acid receptor agonists as proliferators of cardiac progenitor cells through a phenotypic screening approach
L Drowley, J McPheat, A Nordqvist, S Peel, U Karlsson, S Martinsson, ...
Stem cells translational medicine 9 (1), 47-60, 2020
High-content phenotypic assay for proliferation of human iPSC-derived cardiomyocytes identifies L-type calcium channels as targets
LA Woo, S Tkachenko, M Ding, AT Plowright, O Engkvist, H Andersson, ...
Journal of molecular and cellular cardiology 127, 204-214, 2019
Cancer genome analysis informatics
IP Barrett
Genetic Variation, 75-102, 2010
Kinase inhibition leads to hormesis in a dual phosphorylation-dephosphorylation cycle
P Rashkov, IP Barrett, RE Beardmore, C Bendtsen, I Gudelj
PLoS computational biology 12 (11), e1005216, 2016
Blood-brain barrier penetrating ATM inhibitor (AZ32) radiosensitises intracranial gliomas in mice
ST Durant, J Karlin, K Pike, N Colclough, N Mukhopadhyay, SF Ahmad, ...
Cancer Research 76 (14 Supplement), 3041-3041, 2016
Signaling Dynamics Regulating Crosstalks between T-Cell Activation and Immune Checkpoints
M Kreileder, I Barrett, C Bendtsen, D Brennan, W Kolch
Trends in Cell Biology, 2020
Multitask bioactivity predictions using structural chemical and cell morphology information
MA Trapotsi, I Barrett, L Mervin, AM Afzal, N Sturm, O Engkvist, A Bender
ChemRxiv, 2020
Bioinformatic Approaches in the Understanding of Mechanism of Action (MoA)
MA Trapotsi, I Barrett, O Engkvist, A Bender
Target Discovery and Validation: Methods and Strategies for Drug Discovery …, 2019
Comparison of Chemical Structure and Cell Morphology Information for Multitask Bioactivity Predictions
MA Trapotsi, LH Mervin, AM Afzal, N Sturm, O Engkvist, IP Barrett, ...
Journal of Chemical Information and Modeling 61 (3), 1444-1456, 2021
A Review of Biomedical Datasets Relating to Drug Discovery: A Knowledge Graph Perspective
S Bonner, IP Barrett, C Ye, R Swiers, O Engkvist, A Bender, CT Hoyt, ...
arXiv preprint arXiv:2102.10062, 2021
New Associations between Drug-Induced Adverse Events in Animal Models and Humans Reveal Novel Candidate Safety Targets
KA Giblin, D Basili, AM Afzal, L Rosenbrier-Ribeiro, N Greene, I Barrett, ...
Chemical Research in Toxicology, 2020
Abstract A104: AZD1390, a potent and selective orally bioavailable blood-brain barrier-penetrant ATM inhibitor, radiosensitizes and improves survival of orthotopic glioma and …
ST Durant, KG Pike, N Colclough, L Riches, A Garcia-Trinidad, T Hunt, ...
Molecular Cancer Therapeutics 17 (1 Supplement), A104-A104, 2018
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