| Cyclin-dependent kinase (CDK) inhibitors: structure–activity relationships and insights into the CDK-2 selectivity of 6-substituted 2-arylaminopurines CR Coxon, E Anscombe, SJ Harnor, MP Martin, B Carbain, BT Golding, ... Journal of medicinal chemistry 60 (5), 1746-1767, 2017 | 101 | 2017 |
| Targeting DNA‐dependent protein kinase for cancer therapy SJ Harnor, A Brennan, C Cano ChemMedChem 12 (12), 895-900, 2017 | 76 | 2017 |
| Structure-based design of potent and orally active isoindolinone inhibitors of MDM2-p53 protein–protein interaction G Chessari, IR Hardcastle, JS Ahn, B Anil, E Anscombe, RH Bawn, ... Journal of Medicinal Chemistry 64 (7), 4071-4088, 2021 | 35 | 2021 |
| Human toxicity caused by indole and indazole carboxylate synthetic cannabinoid receptor agonists: from horizon scanning to notification SL Hill, M Dunn, C Cano, SJ Harnor, IR Hardcastle, J Grundlingh, ... Clinical Chemistry 64 (2), 346-354, 2018 | 26 | 2018 |
| Identification of a novel orally bioavailable ERK5 inhibitor with selectivity over p38α and BRD4 SM Myers, DC Miller, L Molyneux, M Arasta, RH Bawn, TJ Blackburn, ... European Journal of Medicinal Chemistry 178, 530-543, 2019 | 22 | 2019 |
| Structure-activity analysis of CJ-15,801 analogues that interact with Plasmodium falciparum pantothenate kinase and inhibit parasite proliferation C Spry, AL Sewell, Y Hering, MVJ Villa, J Weber, SJ Hobson, SJ Harnor, ... European Journal of Medicinal Chemistry 143, 1139-1147, 2018 | 19 | 2018 |
| The Enhanced In Vivo Activity of the Combination of a MEK and a PI3K Inhibitor Correlates with [18F]-FLT PET in Human Colorectal Cancer Xenograft Tumour … EJ Haagensen, HD Thomas, I Wilson, SJ Harnor, SL Payne, T Rennison, ... PLoS One 8 (12), e81763, 2013 | 16 | 2013 |
| 2-Arylamino-6-ethynylpurines are cysteine-targeting irreversible inhibitors of Nek2 kinase CJ Matheson, CR Coxon, R Bayliss, K Boxall, B Carbain, AM Fry, ... RSC Medicinal Chemistry 11 (6), 707-731, 2020 | 14 | 2020 |
| Chronic glucokinase activator treatment activates liver Carbohydrate response element binding protein and improves hepatocyte ATP homeostasis during substrate challenge BE Ford, SS Chachra, A Alshawi, A Brennan, S Harnor, C Cano, DJ Baker, ... Diabetes, Obesity and Metabolism 22 (11), 1985-1994, 2020 | 12 | 2020 |
| An alkynylpyrimidine-based covalent inhibitor that targets a unique cysteine in NF-κB-inducing kinase I Al-Khawaldeh, MJ Al Yasiri, GG Aldred, C Basmadjian, C Bordoni, ... Journal of medicinal chemistry 64 (14), 10001-10018, 2021 | 11 | 2021 |
| Concise syntheses of bridged morpholines AV Zaytsev, JE Pickles, SJ Harnor, AP Henderson, M Alyasiri, PG Waddell, ... RSC advances 6 (59), 53955-53957, 2016 | 8 | 2016 |
| Photochemical synthesis of benz[h]isoquinolines BM Abbott, FD Ferrari, SJ Harnor, JC Barnes, R Marquez Tetrahedron 64 (22), 5072-5078, 2008 | 8 | 2008 |
| Advanced approaches of developing targeted covalent drugs C Gai, SJ Harnor, S Zhang, C Cano, C Zhuang, Q Zhao RSC Medicinal Chemistry 13 (12), 1460-1475, 2022 | 7 | 2022 |
| Modulation of ERK5 activity as a therapeutic anti-cancer strategy DC Miller, SJ Harnor, MP Martin, RA Noble, SR Wedge, C Cano Journal of Medicinal Chemistry 66 (7), 4491-4502, 2023 | 4 | 2023 |
| Parallel Optimization of Potency and Pharmacokinetics Leading to the Discovery of a Pyrrole Carboxamide ERK5 Kinase Domain Inhibitor DC Miller, T Reuillon, L Molyneux, T Blackburn, SJ Cook, N Edwards, ... Journal of Medicinal Chemistry 65 (9), 6513-6540, 2022 | 3 | 2022 |
| Synthesis of 3′-deoxy-3′-fluorothymidine (FLT) 5′-O-glucuronide: a reference standard for imaging studies with [18 F] FLT SJ Harnor, T Rennison, M Galler, C Cano, RJ Griffin, DR Newell, ... MedChemComm 5 (7), 984-988, 2014 | 3 | 2014 |
| Targeting DNA-PK as a therapeutic approach in oncology C Cano, SJ Harnor, E Willmore, SR Wedge Targeting the DNA Damage Response for Anti-Cancer Therapy, 339-357, 2018 | 1 | 2018 |
| Modulation of the DNA-Damage Response by Inhibitors of the Phosphatidylinositol 3-Kinase Related Kinase (PIKK) Family S Harnor, J Pickles, C Cano Cancer II, 189-189, 2018 | 1 | 2018 |
| Inhibition of the DNA-dependent protein kinase for cancer therapy SJ Harnor, A Brennan, C Cano Medicinal Chemistry, 2017 | 1 | 2017 |
| Approach in Oncology C Cano, SJ Harnor, E Willmore, SR Wedge Targeting the DNA Damage Response for Anti-Cancer Therapy, 2018 | | 2018 |
