| Direct activation of STING in the tumor microenvironment leads to potent and systemic tumor regression and immunity L Corrales, LH Glickman, SM McWhirter, DB Kanne, KE Sivick, ... Cell reports 11 (7), 1018-1030, 2015 | 1270 | 2015 |
| STING agonist formulated cancer vaccines can cure established tumors resistant to PD-1 blockade J Fu, DB Kanne, M Leong, LH Glickman, SM McWhirter, E Lemmens, ... Science translational medicine 7 (283), 283ra52-283ra52, 2015 | 722 | 2015 |
| Magnitude of therapeutic STING activation determines CD8+ T cell-mediated anti-tumor immunity KE Sivick, AL Desbien, LH Glickman, GL Reiner, L Corrales, NH Surh, ... Cell reports 25 (11), 3074-3085. e5, 2018 | 305 | 2018 |
| Tumor STAT1 transcription factor activity enhances breast tumor growth and immune suppression mediated by myeloid-derived suppressor cells LM Hix, J Karavitis, MW Khan, YH Shi, K Khazaie, M Zhang Journal of Biological Chemistry 288 (17), 11676-11688, 2013 | 141 | 2013 |
| Combining STING-based neoantigen-targeted vaccine with checkpoint modulators enhances antitumor immunity in murine pancreatic cancer HL Kinkead, A Hopkins, E Lutz, AA Wu, M Yarchoan, K Cruz, S Woolman, ... JCI insight 3 (20), 2018 | 136 | 2018 |
| Compositions and methods for activating stimulator of interferon gene-dependent signalling TW Dubensky Jr, DB Kanne, MLL Leong, EE Lemmens, LH Glickman, ... US Patent 9,724,408, 2017 | 118 | 2017 |
| CD1d-expressing breast cancer cells modulate NKT cell-mediated antitumor immunity in a murine model of breast cancer metastasis LM Hix, YH Shi, RR Brutkiewicz, PL Stein, CR Wang, M Zhang PloS one 6 (6), e20702, 2011 | 115 | 2011 |
| NSG mice provide a better spontaneous model of breast cancer metastasis than athymic (nude) mice M Puchalapalli, X Zeng, L Mu, A Anderson, L Hix Glickman, M Zhang, ... PLoS One 11 (9), e0163521, 2016 | 109 | 2016 |
| Bioactive carotenoids: potent antioxidants and regulators of gene expression LM Hix, SF Lockwood, JS Bertram Redox report 9 (4), 181-191, 2004 | 109 | 2004 |
| Regulation of COX2 expression in mouse mammary tumor cells controls bone metastasis and PGE2-induction of regulatory T cell migration J Karavitis, LM Hix, YH Shi, RF Schultz, K Khazaie, M Zhang Public Library of Science 7 (9), e46342, 2012 | 105 | 2012 |
| Mast Cell 5-Lipoxygenase Activity Promotes Intestinal Polyposis in APCΔ468 Mice EC Cheon, K Khazaie, MW Khan, MJ Strouch, SB Krantz, J Phillips, ... Cancer research 71 (5), 1627-1636, 2011 | 96 | 2011 |
| Poliovirus pathogenesis in a new poliovirus receptor transgenic mouse model: age-dependent paralysis and a mucosal route of infection S Crotty, L Hix, LJ Sigal, R Andino Journal of general virology 83 (7), 1707-1720, 2002 | 95 | 2002 |
| Compositions comprising cyclic purine dinucleotides having defined stereochemistries and methods for their preparation and use TW Dubensky Jr, DB Kanne, MLL Leong, EE Lemmens, LH Glickman US Patent 9,695,212, 2017 | 85 | 2017 |
| Compositions comprising cyclic purine dinucleotides having defined stereochemistries and methods for their preparation and use TW Dubensky Jr, DB Kanne, MLL Leong, EE Lemmens, LH Glickman US Patent 9,695,212, 2017 | 80 | 2017 |
| TNFα and radioresistant stromal cells are essential for therapeutic efficacy of cyclic dinucleotide STING agonists in nonimmunogenic tumors BJ Francica, A Ghasemzadeh, AL Desbien, D Theodros, KE Sivick, ... Cancer immunology research 6 (4), 422-433, 2018 | 72 | 2018 |
| Upregulation of connexin 43 protein expression and increased gap junctional communication by water soluble disodium disuccinate astaxanthin derivatives LM Hix, SF Lockwood, JS Bertram Cancer letters 211 (1), 25-37, 2004 | 68 | 2004 |
| Structural carotenoid analogs for the inhibition and amelioration of disease SF Lockwood, S O'malley, DG Watumull, LM Hix, H Jackson, G Nadolski US Patent 7,145,025, 2006 | 63 | 2006 |
| Sprouty proteins inhibit receptor-mediated activation of phosphatidylinositol-specific phospholipase C S Akbulut, AL Reddi, P Aggarwal, C Ambardekar, B Canciani, MKH Kim, ... Molecular biology of the cell 21 (19), 3487-3496, 2010 | 60 | 2010 |
| Structural carotenoid analogs for the inhibition and amelioration of disease SF Lockwood, S O'malley, DG Watumull, LM Hix, H Jackson, G Nadolski US Patent 7,145,025, 2006 | 58 | 2006 |
| Inhibition of chemically-induced neoplastic transformation by a novel tetrasodium diphosphate astaxanthin derivative LM Hix, DA Frey, MD McLaws, M Østerlie, SF Lockwood, JS Bertram Carcinogenesis 26 (9), 1634-1641, 2005 | 54 | 2005 |
