High-resolution crystal structure of an engineered human β2-adrenergic G protein–coupled receptor V Cherezov, DM Rosenbaum, MA Hanson, SGF Rasmussen, FS Thian, ... science 318 (5854), 1258-1265, 2007 | 4136 | 2007 |
Crystal structure of the β2 adrenergic receptor–Gs protein complex SGF Rasmussen, BT DeVree, Y Zou, AC Kruse, KY Chung, TS Kobilka, ... Nature 477 (7366), 549-555, 2011 | 3540 | 2011 |
The structure and function of G-protein-coupled receptors DM Rosenbaum, SGF Rasmussen, BK Kobilka Nature 459 (7245), 356-363, 2009 | 3091 | 2009 |
Crystal structure of the human β2 adrenergic G-protein-coupled receptor SGF Rasmussen, HJ Choi, DM Rosenbaum, TS Kobilka, FS Thian, ... Nature 450 (7168), 383-387, 2007 | 2634 | 2007 |
Structure of a nanobody-stabilized active state of the β2 adrenoceptor SGF Rasmussen, HJ Choi, JJ Fung, E Pardon, P Casarosa, PS Chae, ... Nature 469 (7329), 175-180, 2011 | 2035 | 2011 |
GPCR engineering yields high-resolution structural insights into β2-adrenergic receptor function DM Rosenbaum, V Cherezov, MA Hanson, SGF Rasmussen, FS Thian, ... science 318 (5854), 1266-1273, 2007 | 1771 | 2007 |
Cloning of the gene and cDNA for mammalian β-adrenergic receptor and homology with rhodopsin RAF Dixon, BK Kobilka, DJ Strader, JL Benovic, HG Dohlman, T Frielle, ... Nature 321 (6065), 75-79, 1986 | 1769 | 1986 |
Crystal structure of the µ-opioid receptor bound to a morphinan antagonist A Manglik, AC Kruse, TS Kobilka, FS Thian, JM Mathiesen, RK Sunahara, ... Nature 485 (7398), 321-326, 2012 | 1637 | 2012 |
Functional selectivity and classical concepts of quantitative pharmacology JD Urban, WP Clarke, M Von Zastrow, DE Nichols, B Kobilka, H Weinstein, ... Journal of Pharmacology and Experimental Therapeutics 320 (1), 1-13, 2007 | 1332 | 2007 |
The molecular basis of G protein–coupled receptor activation WI Weis, BK Kobilka Annual review of biochemistry 87 (1), 897-919, 2018 | 1110 | 2018 |
βAR signaling required for diet-induced thermogenesis and obesity resistance ES Bachman, H Dhillon, CY Zhang, S Cinti, AC Bianco, BK Kobilka, ... Science 297 (5582), 843-845, 2002 | 1067 | 2002 |
Chimeric α2-,β2-Adrenergic Receptors: Delineation of Domains Involved in Effector Coupling and Ligand Binding Specificity BK Kobilka, TS Kobilka, K Daniel, JW Regan, MG Caron, RJ Lefkowitz Science 240 (4857), 1310-1316, 1988 | 1056 | 1988 |
Structure-based discovery of opioid analgesics with reduced side effects A Manglik, H Lin, DK Aryal, JD McCorvy, D Dengler, G Corder, A Levit, ... Nature 537 (7619), 185-190, 2016 | 1011 | 2016 |
Structure and dynamics of GPCR signaling complexes D Hilger, M Masureel, BK Kobilka Nature structural & molecular biology 25 (1), 4-12, 2018 | 1009 | 2018 |
Cloning, Sequencing, and Expression of the Gene Coding for the Human Platelet α2-Adrenergic Receptor BK Kobilka, H Matsui, TS Kobilka, TL Yang-Feng, U Francke, MG Caron, ... Science 238 (4827), 650-656, 1987 | 1001 | 1987 |
Activation and allosteric modulation of a muscarinic acetylcholine receptor AC Kruse, AM Ring, A Manglik, J Hu, K Hu, K Eitel, H Hübner, E Pardon, ... Nature 504 (7478), 101-106, 2013 | 990 | 2013 |
G protein coupled receptor structure and activation BK Kobilka Biochimica et Biophysica Acta (BBA)-Biomembranes 1768 (4), 794-807, 2007 | 950 | 2007 |
Structural insights into µ-opioid receptor activation W Huang, A Manglik, AJ Venkatakrishnan, T Laeremans, EN Feinberg, ... Nature 524 (7565), 315-321, 2015 | 939 | 2015 |
Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist K Haga, AC Kruse, H Asada, T Yurugi-Kobayashi, M Shiroishi, C Zhang, ... Nature 482 (7386), 547-551, 2012 | 938 | 2012 |
Structure and dynamics of the M3 muscarinic acetylcholine receptor AC Kruse, J Hu, AC Pan, DH Arlow, DM Rosenbaum, E Rosemond, ... Nature 482 (7386), 552-556, 2012 | 935 | 2012 |