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Alex G Baldwin
Alex G Baldwin
Research Fellow in Medicinal Chemistry, Medicines Discovery Institute
Verified email at cardiff.ac.uk
Title
Cited by
Cited by
Year
Fenamate NSAIDs inhibit the NLRP3 inflammasome and protect against Alzheimer’s disease in rodent models
MJD Daniels, J Rivers-Auty, T Schilling, NG Spencer, W Watremez, ...
Nature communications 7 (1), 12504, 2016
3982016
Inhibiting the inflammasome: a chemical perspective
AG Baldwin, D Brough, S Freeman
Journal of medicinal chemistry 59 (5), 1691-1710, 2016
1632016
Boron-based inhibitors of the NLRP3 inflammasome
AG Baldwin, J Rivers-Auty, MJD Daniels, CS White, CH Schwalbe, ...
Cell Chemical Biology 24 (11), 1321-1335. e5, 2017
1012017
Development of a characterised tool kit for the interrogation of NLRP3 inflammasome-dependent responses
E Redondo-Castro, D Faust, S Fox, AG Baldwin, S Osborne, MJ Haley, ...
Scientific reports 8 (1), 5667, 2018
292018
Design, synthesis and evaluation of oxazaborine inhibitors of the NLRP3 inflammasome
AG Baldwin, VS Tapia, T Swanton, CS White, JA Beswick, D Brough, ...
ChemMedChem 13 (4), 312-320, 2018
292018
Synthesis and antibacterial activities of enamine derivatives of dehydroacetic acid
AG Baldwin, J Bevan, D Brough, R Ledder, S Freeman
Medicinal Chemistry Research 27, 884-889, 2018
172018
Evaluation of analogues of furan-amidines as inhibitors of NQO2
S Alnabulsi, B Hussein, E Santina, I Alsalahat, M Kadirvel, RN Magwaza, ...
Bioorganic & medicinal chemistry letters 28 (8), 1292-1297, 2018
162018
Cyclic diarylboron derivatives as NLRP3 inflammasome inhibitors
D Brough, SMR ALLAN, S Freeman, AG BALDWIN
62017
Comparative analysis of small-molecule LIMK1/2 inhibitors: chemical synthesis, biochemistry, and cellular activity
R Collins, H Lee, DH Jones, JM Elkins, JA Gillespie, C Thomas, ...
Journal of Medicinal Chemistry 65 (20), 13705-13713, 2022
42022
Cyclic diarylboron derivatives as NLRP3 inflammasome inhibitors
D Brough, SMR Allan, S Freeman, AG Baldwin
US Patent, 2020
12020
NOVEL NLRP3 INFLAMMASOME INHIBITORS: EVALUATION IN IL-1β RELEASE AND HIGH-CONTENT ASC-SPECK CELLULAR ASSAYS
D Faust, SG Fox, D Brough, E Redondo-Castro, S Freeman, AG Baldwin, ...
Alzheimer's & Dementia: The Journal of the Alzheimer's Association 13 (7), P629, 2017
2017
Inflammation Control: Novel Boron-Based Inhibitors of IL-1β Release
AG Baldwin
PQDT-Global, 2017
2017
Boron-based small molecule inhibitors of the NLRP3 inflammasome for the treatment of sterile inflammation.
A Baldwin, J Rivers-Auty, H England, N Luheshi, M Daniels, S Allan, ...
Medicinal Chemistry of Boron Compounds, 2015
2015
A novel small molecule inhibitor of the NLRP3 inflammasome for the treatment of sterile inflammation
A Baldwin, J Rivers-Auty, H England, N Luheshi, M Daniels, S Allan, ...
12th World Congress on Inflammation (WCI 2015), 2015
2015
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Articles 1–14