Fenamate NSAIDs inhibit the NLRP3 inflammasome and protect against Alzheimer’s disease in rodent models MJD Daniels, J Rivers-Auty, T Schilling, NG Spencer, W Watremez, ... Nature communications 7 (1), 12504, 2016 | 398 | 2016 |
Inhibiting the inflammasome: a chemical perspective AG Baldwin, D Brough, S Freeman Journal of medicinal chemistry 59 (5), 1691-1710, 2016 | 163 | 2016 |
Boron-based inhibitors of the NLRP3 inflammasome AG Baldwin, J Rivers-Auty, MJD Daniels, CS White, CH Schwalbe, ... Cell Chemical Biology 24 (11), 1321-1335. e5, 2017 | 101 | 2017 |
Development of a characterised tool kit for the interrogation of NLRP3 inflammasome-dependent responses E Redondo-Castro, D Faust, S Fox, AG Baldwin, S Osborne, MJ Haley, ... Scientific reports 8 (1), 5667, 2018 | 29 | 2018 |
Design, synthesis and evaluation of oxazaborine inhibitors of the NLRP3 inflammasome AG Baldwin, VS Tapia, T Swanton, CS White, JA Beswick, D Brough, ... ChemMedChem 13 (4), 312-320, 2018 | 29 | 2018 |
Synthesis and antibacterial activities of enamine derivatives of dehydroacetic acid AG Baldwin, J Bevan, D Brough, R Ledder, S Freeman Medicinal Chemistry Research 27, 884-889, 2018 | 17 | 2018 |
Evaluation of analogues of furan-amidines as inhibitors of NQO2 S Alnabulsi, B Hussein, E Santina, I Alsalahat, M Kadirvel, RN Magwaza, ... Bioorganic & medicinal chemistry letters 28 (8), 1292-1297, 2018 | 16 | 2018 |
Cyclic diarylboron derivatives as NLRP3 inflammasome inhibitors D Brough, SMR ALLAN, S Freeman, AG BALDWIN | 6 | 2017 |
Comparative analysis of small-molecule LIMK1/2 inhibitors: chemical synthesis, biochemistry, and cellular activity R Collins, H Lee, DH Jones, JM Elkins, JA Gillespie, C Thomas, ... Journal of Medicinal Chemistry 65 (20), 13705-13713, 2022 | 4 | 2022 |
Cyclic diarylboron derivatives as NLRP3 inflammasome inhibitors D Brough, SMR Allan, S Freeman, AG Baldwin US Patent, 2020 | 1 | 2020 |
NOVEL NLRP3 INFLAMMASOME INHIBITORS: EVALUATION IN IL-1β RELEASE AND HIGH-CONTENT ASC-SPECK CELLULAR ASSAYS D Faust, SG Fox, D Brough, E Redondo-Castro, S Freeman, AG Baldwin, ... Alzheimer's & Dementia: The Journal of the Alzheimer's Association 13 (7), P629, 2017 | | 2017 |
Inflammation Control: Novel Boron-Based Inhibitors of IL-1β Release AG Baldwin PQDT-Global, 2017 | | 2017 |
Boron-based small molecule inhibitors of the NLRP3 inflammasome for the treatment of sterile inflammation. A Baldwin, J Rivers-Auty, H England, N Luheshi, M Daniels, S Allan, ... Medicinal Chemistry of Boron Compounds, 2015 | | 2015 |
A novel small molecule inhibitor of the NLRP3 inflammasome for the treatment of sterile inflammation A Baldwin, J Rivers-Auty, H England, N Luheshi, M Daniels, S Allan, ... 12th World Congress on Inflammation (WCI 2015), 2015 | | 2015 |