| Genetic mechanisms of critical illness in COVID-19 E Pairo-Castineira, S Clohisey, L Klaric, AD Bretherick, K Rawlik, D Pasko, ... Nature 591 (7848), 92-98, 2021 | 1297 | 2021 |
| Mapping the human genetic architecture of COVID-19 Writing group Writing group leaders Pathak Gita A. 6 Andrews Shea J. 7 Kanai ... Nature 600 (7889), 472-477, 2021 | 714 | 2021 |
| Promoting coherent minimum reporting guidelines for biological and biomedical investigations: the MIBBI project CF Taylor, D Field, SA Sansone, J Aerts, R Apweiler, M Ashburner, ... Nature biotechnology 26 (8), 889-896, 2008 | 617 | 2008 |
| Ring1B compacts chromatin structure and represses gene expression independent of histone ubiquitination R Eskeland, M Leeb, GR Grimes, C Kress, S Boyle, D Sproul, N Gilbert, ... Molecular cell 38 (3), 452-464, 2010 | 608 | 2010 |
| Enzymatic removal of ribonucleotides from DNA is essential for mammalian genome integrity and development MAM Reijns, B Rabe, RE Rigby, P Mill, KR Astell, LA Lettice, S Boyle, ... Cell 149 (5), 1008-1022, 2012 | 505 | 2012 |
| Psip1/Ledgf p52 binds methylated histone H3K36 and splicing factors and contributes to the regulation of alternative splicing MM Pradeepa, HG Sutherland, J Ule, GR Grimes, WA Bickmore PLoS genetics 8 (5), e1002717, 2012 | 369 | 2012 |
| Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk MG Dunlop, SE Dobbins, SM Farrington, AM Jones, C Palles, N Whiffin, ... Nature genetics 44 (7), 770-776, 2012 | 279 | 2012 |
| Decreased enhancer-promoter proximity accompanying enhancer activation NS Benabdallah, I Williamson, RS Illingworth, L Kane, S Boyle, ... Molecular cell 76 (3), 473-484. e7, 2019 | 252 | 2019 |
| Histone H3 globular domain acetylation identifies a new class of enhancers MM Pradeepa, GR Grimes, Y Kumar, G Olley, GCA Taylor, R Schneider, ... Nature genetics 48 (6), 681-686, 2016 | 236 | 2016 |
| Ribonuclease H2 mutations induce a cGAS/STING‐dependent innate immune response KJ Mackenzie, P Carroll, L Lettice, Ž Tarnauskaitė, K Reddy, F Dix, ... The EMBO journal 35 (8), 831-844, 2016 | 235 | 2016 |
| Opposing functions of the ETS factor family define Shh spatial expression in limb buds and underlie polydactyly LA Lettice, I Williamson, JH Wiltshire, S Peluso, PS Devenney, AE Hill, ... Developmental cell 22 (2), 459-467, 2012 | 182 | 2012 |
| Human β‐defensin 3 affects the activity of pro‐inflammatory pathways associated with MyD88 and TRIF F Semple, H MacPherson, S Webb, SL Cox, LJ Mallin, C Tyrrell, ... European journal of immunology 41 (11), 3291-3300, 2011 | 164 | 2011 |
| A prenylated dsRNA sensor protects against severe COVID-19 A Wickenhagen, E Sugrue, S Lytras, S Kuchi, M Noerenberg, ML Turnbull, ... Science 374 (6567), eabj3624, 2021 | 139 | 2021 |
| BRD4 interacts with NIPBL and BRD4 is mutated in a Cornelia de Lange–like syndrome G Olley, M Ansari, H Bengani, GR Grimes, J Rhodes, A von Kriegsheim, ... Nature Genetics 50 (3), 329-332, 2018 | 118 | 2018 |
| DNA methylation directs polycomb-dependent 3D genome re-organization in naive pluripotency K McLaughlin, IM Flyamer, JP Thomson, HK Mjoseng, R Shukla, ... Cell Reports 29 (7), 1974-1985. e6, 2019 | 93 | 2019 |
| DHX34 and NBAS form part of an autoregulatory NMD circuit that regulates endogenous RNA targets in human cells, zebrafish and Caenorhabditis elegans D Longman, N Hug, M Keith, C Anastasaki, EE Patton, G Grimes, ... Nucleic acids research 41 (17), 8319-8331, 2013 | 92 | 2013 |
| Anterior-posterior differences in HoxD chromatin topology in limb development I Williamson, R Eskeland, LA Lettice, AE Hill, S Boyle, GR Grimes, RE Hill, ... Development 139 (17), 3157-3167, 2012 | 84 | 2012 |
| PRC1 and PRC2 are not required for targeting of H2A. Z to developmental genes in embryonic stem cells RS Illingworth, CH Botting, GR Grimes, WA Bickmore, R Eskeland PloS one 7 (4), e34848, 2012 | 49 | 2012 |
| Psip1/Ledgf p75 restrains Hox gene expression by recruiting both trithorax and polycomb group proteins MM Pradeepa, GR Grimes, GCA Taylor, HG Sutherland, WA Bickmore Nucleic acids research 42 (14), 9021-9032, 2014 | 35 | 2014 |
| Psip1/p52 regulates posterior Hoxa genes through activation of lncRNA Hottip MM Pradeepa, F McKenna, GCA Taylor, H Bengani, GR Grimes, AJ Wood, ... PLoS genetics 13 (4), e1006677, 2017 | 34 | 2017 |
W BickmoreMRC Human Genetics Unit, University of EdinburghVerified email at igmm.ed.ac.uk
