X-ray screening identifies active site and allosteric inhibitors of SARS-CoV-2 main protease S Günther, PYA Reinke, Y Fernández-García, J Lieske, TJ Lane, HM Ginn, ... Science 372 (6542), 642-646, 2021 | 276 | 2021 |
All three domains of the hepatitis C virus nonstructural NS5A protein contribute to RNA binding TL Foster, T Belyaeva, NJ Stonehouse, AR Pearson, M Harris Journal of virology 84 (18), 9267-9277, 2010 | 154 | 2010 |
MauG, a novel diheme protein required for tryptophan tryptophylquinone biogenesis Y Wang, ME Graichen, A Liu, AR Pearson, CM Wilmot, VL Davidson Biochemistry 42 (24), 7318-7325, 2003 | 148 | 2003 |
Using synchrotrons and XFELs for time-resolved X-ray crystallography and solution scattering experiments on biomolecules M Levantino, BA Yorke, DCF Monteiro, M Cammarata, AR Pearson Current opinion in structural biology 35, 41-48, 2015 | 138 | 2015 |
Fixed target matrix for femtosecond time-resolved and in situ serial micro-crystallography C Mueller, A Marx, SW Epp, Y Zhong, A Kuo, AR Balo, J Soman, F Schotte, ... Structural Dynamics 2 (5), 2015 | 134 | 2015 |
Improving Escherichia coli alkaline phosphatase efficacy by additional mutations inside and outside the catalytic pocket BH Muller, C Lamoure, MH Le Du, L Cattolico, E Lajeunesse, F Lemaître, ... Chembiochem 2 (7‐8), 517-523, 2001 | 128 | 2001 |
Nature of the ferryl heme in compounds I and II A Gumiero, CL Metcalfe, AR Pearson, EL Raven, PCE Moody Journal of biological chemistry 286 (2), 1260-1268, 2011 | 119 | 2011 |
Packaging signals in single-stranded RNA viruses: nature’s alternative to a purely electrostatic assembly mechanism PG Stockley, R Twarock, SE Bakker, AM Barker, A Borodavka, ... Journal of biological physics 39, 277-287, 2013 | 110 | 2013 |
Complex interplay between epitope specificity and isotype dictates the biological activity of anti-human CD40 antibodies X Yu, HTC Chan, CM Orr, O Dadas, SG Booth, LN Dahal, CA Penfold, ... Cancer cell 33 (4), 664-675. e4, 2018 | 97 | 2018 |
Exploring molecular oxygen pathways in Hansenula polymorpha copper-containing amine oxidase BJ Johnson, J Cohen, RW Welford, AR Pearson, K Schulten, JP Klinman, ... Journal of Biological Chemistry 282 (24), 17767-17776, 2007 | 94 | 2007 |
Fixed target combined with spectral mapping: approaching 100% hit rates for serial crystallography S Oghbaey, A Sarracini, HM Ginn, O Pare-Labrosse, A Kuo, A Marx, ... Acta Crystallographica Section D: Structural Biology 72 (8), 944-955, 2016 | 92 | 2016 |
Further insights into quinone cofactor biogenesis: probing the role of mauG in methylamine dehydrogenase tryptophan tryptophylquinone formation AR Pearson, T De la Mora-Rey, ME Graichen, Y Wang, LH Jones, ... Biochemistry 43 (18), 5494-5502, 2004 | 92 | 2004 |
Liquid application method for time-resolved analyses by serial synchrotron crystallography P Mehrabi, EC Schulz, M Agthe, S Horrell, G Bourenkov, D von Stetten, ... Nature methods 16 (10), 979-982, 2019 | 85 | 2019 |
Serial synchrotron crystallography for time-resolved structural biology AR Pearson, P Mehrabi Current Opinion in Structural Biology 65, 168-174, 2020 | 77 | 2020 |
X-ray-based techniques to study the nano–bio interface C Sanchez-Cano, RA Alvarez-Puebla, JM Abendroth, T Beck, R Blick, ... ACS nano 15 (3), 3754-3807, 2021 | 72 | 2021 |
Structure‐guided design affirms inhibitors of hepatitis C virus p7 as a viable class of antivirals targeting virion release TL Foster, GS Thompson, AP Kalverda, J Kankanala, M Bentham, ... Hepatology 59 (2), 408-422, 2014 | 68 | 2014 |
MauG-dependent in vitro biosynthesis of tryptophan tryptophylquinone in methylamine dehydrogenase Y Wang, X Li, LH Jones, AR Pearson, CM Wilmot, VL Davidson Journal of the American Chemical Society 127 (23), 8258-8259, 2005 | 65 | 2005 |
The Crystal Structure of Cytochrome P460 of Nitrosomonas europaea Reveals a Novel Cytochrome Fold and Heme−Protein Cross-link, AR Pearson, BO Elmore, C Yang, JD Ferrara, AB Hooper, CM Wilmot Biochemistry 46 (28), 8340-8349, 2007 | 61 | 2007 |
Microspectrophotometry for structural enzymology AR Pearson, A Mozzarelli, GL Rossi Current Opinion in Structural Biology 14 (6), 656-662, 2004 | 57 | 2004 |
Sequence-specific, RNA–protein interactions overcome electrostatic barriers preventing assembly of satellite tobacco necrosis virus coat protein RJ Ford, AM Barker, SE Bakker, RH Coutts, NA Ranson, SEV Phillips, ... Journal of molecular biology 425 (6), 1050-1064, 2013 | 55 | 2013 |