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david hargreaves
david hargreaves
Verified email at astrazeneca.com
Title
Cited by
Cited by
Year
Discovery of Mcl-1-specific inhibitor AZD5991 and preclinical activity in multiple myeloma and acute myeloid leukemia
AE Tron, MA Belmonte, A Adam, BM Aquila, LH Boise, E Chiarparin, ...
Nature communications 9 (1), 5341, 2018
4352018
Crystal structure of DNA recombination protein RuvA and a model for its binding to the Holliday junction
JB Rafferty, SE Sedelnikova, D Hargreaves, PJ Artymiuk, PJ Baker, ...
Science 274 (5286), 415-421, 1996
2141996
Crystal structure of E.coli RuvA with bound DNA Holliday junction at 6 Å resolution
D Hargreaves, DW Rice, SE Sedelnikova, PJ Artymiuk, RG Lloyd, ...
Nature structural biology 5 (6), 441-446, 1998
1701998
Development of a novel B-cell lymphoma 6 (BCL6) PROTAC to provide insight into small molecule targeting of BCL6
W McCoull, T Cheung, E Anderson, P Barton, J Burgess, K Byth, Q Cao, ...
ACS Chemical Biology 13 (11), 3131-3141, 2018
1302018
Structure of IL-17A in complex with a potent, fully human neutralizing antibody
S Gerhardt, WM Abbott, D Hargreaves, RA Pauptit, RA Davies, ...
Journal of molecular biology 394 (5), 905-921, 2009
1012009
Crystal structures of human ADAMTS-1 reveal a conserved catalytic domain and a disintegrin-like domain with a fold homologous to cysteine-rich domains
S Gerhardt, G Hassall, P Hawtin, E McCall, L Flavell, C Minshull, ...
Journal of molecular biology 373 (4), 891-902, 2007
1012007
Structural and functional analysis of the kid toxin protein from E. coli plasmid R1
D Hargreaves, S Santos-Sierra, R Giraldo, R Sabariegos-Jareño, ...
Structure 10 (10), 1425-1433, 2002
972002
Computational design of epitope-specific functional antibodies
G Nimrod, S Fischman, M Austin, A Herman, F Keyes, O Leiderman, ...
Cell reports 25 (8), 2121-2131. e5, 2018
712018
Using isoelectric point to determine the pH for initial protein crystallization trials
J Kirkwood, D Hargreaves, SOKJ Wilson
Bioinformatics 2015, 1-8, doi: 10.1093/bioinformatics/btv011, 2015
712015
Structure based design of non-natural peptidic macrocyclic Mcl-1 inhibitors
JW Johannes, S Bates, C Beigie, MA Belmonte, J Breen, S Cao, ...
ACS medicinal chemistry letters 8 (2), 239-244, 2017
702017
Discovery of Pyrazolo[1,5-a]pyrimidine B-Cell Lymphoma 6 (BCL6) Binders and Optimization to High Affinity Macrocyclic Inhibitors
W McCoull, RD Abrams, E Anderson, K Blades, P Barton, M Box, ...
Journal of Medicinal Chemistry 60 (10), 4386-4402, 2017
672017
Discovery of a Potent, Selective, and Orally Bioavailable Acidic 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1) Inhibitor: Discovery of 2-[(3S)-1-[5 …
JS Scott, SS Bowker, J Deschoolmeester, S Gerhardt, D Hargreaves, ...
Journal of medicinal chemistry 55 (12), 5951-5964, 2012
572012
Shifts
PJ Baker, D Hargreaves, S Bailey, JB Rafferty, PJ Artymiuk, DW Rice
Routledge encyclopedia of translation studies, 289-293, 2009
552009
Novel acidic 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor with reduced acyl glucuronide liability: The discovery of 4-[4-(2-adamantylcarbamoyl)-5-tert-butyl …
JS Scott, J deSchoolmeester, E Kilgour, RM Mayers, MJ Packer, ...
Journal of medicinal chemistry 55 (22), 10136-10147, 2012
492012
Structure and characterization of a high affinity C5a monoclonal antibody that blocks binding to C5aR1 and C5aR2 receptors
CS Colley, B Popovic, S Sridharan, JE Debreczeni, D Hargeaves, M Fung, ...
MAbs 10 (1), 104-117, 2018
332018
Abstract DDT01-02: AZD5991: A potent and selective macrocyclic inhibitor of Mcl-1 for treatment of hematologic cancers
AW Hird, JP Secrist, A Adam, MA Belmonte, E Gangl, F Gibbons, ...
Cancer Research 77 (13_Supplement), DDT01-02-DDT01-02, 2017
302017
Analysis of crystallization data in the Protein Data Bank
J Kirkwood, D Hargreaves, S O'Keefe, J Wilson
Acta Crystallographica Section F: Structural Biology Communications 71 (10 …, 2015
282015
Structural similarities between Escherichia coli RuvA protein and other DNA-binding proteins and a mutational analysis of its binding to the Holliday junction
JB Rafferty, SM Ingleston, D Hargreaves, PJ Artymiuk, GJ Sharples, ...
Journal of molecular biology 278 (1), 105-116, 1998
281998
Selective non zinc binding inhibitors of MMP13
C De Savi, AD Morley, A Ting, I Nash, K Karabelas, CM Wood, M James, ...
Bioorganic & medicinal chemistry letters 21 (14), 4215-4219, 2011
262011
Engineering a high-affinity anti-IL-15 antibody: crystal structure reveals an α-helix in VH CDR3 as key component of paratope
DC Lowe, S Gerhardt, A Ward, D Hargreaves, M Anderson, F Ferraro, ...
Journal of molecular biology 406 (1), 160-175, 2011
232011
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