Jan Bieschke
TitleCited byYear
EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers
DE Ehrnhoefer, J Bieschke, A Boeddrich, M Herbst, L Masino, R Lurz, ...
Nature structural & molecular biology 15 (6), 558, 2008
10062008
Opposing activities protect against age-onset proteotoxicity
E Cohen, J Bieschke, RM Perciavalle, JW Kelly, A Dillin
Science 313 (5793), 1604-1610, 2006
7742006
EGCG remodels mature α-synuclein and amyloid-β fibrils and reduces cellular toxicity
J Bieschke, J Russ, RP Friedrich, DE Ehrnhoefer, H Wobst, ...
Proceedings of the National Academy of Sciences 107 (17), 7710-7715, 2010
6452010
Small-molecule conversion of toxic oligomers to nontoxic β-sheet–rich amyloid fibrils
J Bieschke, M Herbst, T Wiglenda, RP Friedrich, A Boeddrich, F Schiele, ...
Nature chemical biology 8 (1), 93, 2012
3032012
Ultrasensitive detection of pathological prion protein aggregates by dual-color scanning for intensely fluorescent targets
J Bieschke, A Giese, W Schulz-Schaeffer, I Zerr, S Poser, M Eigen, ...
Proceedings of the National Academy of Sciences 97 (10), 5468-5473, 2000
2922000
Metabolite-initiated protein misfolding may trigger Alzheimer's disease
Q Zhang, ET Powers, J Nieva, ME Huff, MA Dendle, J Bieschke, CG Glabe, ...
Proceedings of the National Academy of Sciences 101 (14), 4752-4757, 2004
2262004
Kinetic investigations by fluorescence correlation spectroscopy: the analytical and diagnostic potential of diffusion studies
P Schwille, J Bieschke, F Oehlenschläger
Biophysical chemistry 66 (2-3), 211-228, 1997
2131997
Structure–function–folding relationship in a WW domain
M Jäger, Y Zhang, J Bieschke, H Nguyen, M Dendle, ME Bowman, ...
Proceedings of the National Academy of Sciences 103 (28), 10648-10653, 2006
2012006
Rapid assay processing by integration of dual-color fluorescence cross-correlation spectroscopy: high throughput screening for enzyme activity
A Koltermann, U Kettling, J Bieschke, T Winkler, M Eigen
Proceedings of the National Academy of Sciences 95 (4), 1421-1426, 1998
1841998
Oxidative metabolites accelerate Alzheimer's amyloidogenesis by a two-step mechanism, eliminating the requirement for nucleation
J Bieschke, Q Zhang, ET Powers, RA Lerner, JW Kelly
Biochemistry 44 (13), 4977-4983, 2005
1502005
The oxidative stress metabolite 4-hydroxynonenal promotes Alzheimer protofibril formation
SJ Siegel, J Bieschke, ET Powers, JW Kelly
Biochemistry 46 (6), 1503-1510, 2007
1442007
Structural properties of EGCG-induced, nontoxic Alzheimer's disease Aβ oligomers
JML del Amo, U Fink, M Dasari, G Grelle, EE Wanker, J Bieschke, B Reif
Journal of molecular biology 421 (4-5), 517-524, 2012
1252012
Autocatalytic self-propagation of misfolded prion protein
J Bieschke, P Weber, N Sarafoff, M Beekes, A Giese, H Kretzschmar
Proceedings of the National Academy of Sciences 101 (33), 12207-12211, 2004
1182004
Small molecule oxidation products trigger disease-associated protein misfolding
J Bieschke, Q Zhang, DA Bosco, RA Lerner, ET Powers, P Wentworth, ...
Accounts of chemical research 39 (9), 611-619, 2006
1012006
Black tea theaflavins inhibit formation of toxic amyloid-β and α-synuclein fibrils
G Grelle, A Otto, M Lorenz, RF Frank, EE Wanker, J Bieschke
Biochemistry 50 (49), 10624-10636, 2011
972011
Tau trimers are the minimal propagation unit spontaneously internalized to seed intracellular aggregation
H Mirbaha, BB Holmes, DW Sanders, J Bieschke, MI Diamond
Journal of Biological Chemistry 290 (24), 14893-14903, 2015
962015
Systematic identification of antiprion drugs by high-throughput screening based on scanning for intensely fluorescent targets
U Bertsch, KF Winklhofer, T Hirschberger, J Bieschke, P Weber, FU Hartl, ...
Journal of virology 79 (12), 7785-7791, 2005
912005
Differential constitutive and activation‐dependent expression of prion protein in human peripheral blood leucocytes
J Dürig, A Giese, W Schulz‐Schaeffer, C Rosenthal, U Schmücker, ...
British journal of haematology 108 (3), 488-495, 2000
872000
Bacterial Inclusion Bodies of Alzheimer's Disease β‐Amyloid Peptides Can Be Employed To Study Native‐Like Aggregation Intermediate States
M Dasari, A Espargaro, R Sabate, JM Lopez del Amo, U Fink, G Grelle, ...
ChemBioChem 12 (3), 407-423, 2011
812011
The green tea polyphenol (−)‐epigallocatechin gallate prevents the aggregation of tau protein into toxic oligomers at substoichiometric ratios
HJ Wobst, A Sharma, MI Diamond, EE Wanker, J Bieschke
FEBS letters 589 (1), 77-83, 2015
762015
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Articles 1–20