Boris Kholodenko
Boris Kholodenko
Professor of Systems Biology, University College Dublin
Verified email at ucd.ie - Homepage
TitleCited byYear
Cell-signalling dynamics in time and space
BN Kholodenko
Nature reviews Molecular cell biology 7 (3), 165, 2006
12242006
Negative feedback and ultrasensitivity can bring about oscillations in the mitogen‐activated protein kinase cascades
BN Kholodenko
European journal of biochemistry 267 (6), 1583-1588, 2000
7402000
Quantification of short term signaling by the epidermal growth factor receptor
BN Kholodenko, OV Demin, G Moehren, JB Hoek
Journal of Biological Chemistry 274 (42), 30169-30181, 1999
7001999
Signaling switches and bistability arising from multisite phosphorylation in protein kinase cascades
NI Markevich, JB Hoek, BN Kholodenko
The Journal of cell biology 164 (3), 353-359, 2004
6822004
Signalling ballet in space and time
BN Kholodenko, JF Hancock, W Kolch
Nature reviews Molecular cell biology 11 (6), 414, 2010
5312010
Untangling the wires: a strategy to trace functional interactions in signaling and gene networks
BN Kholodenko, A Kiyatkin, FJ Bruggeman, E Sontag, HV Westerhoff, ...
Proceedings of the National Academy of Sciences 99 (20), 12841-12846, 2002
4322002
Cross-talk between mitogenic Ras/MAPK and survival PI3K/Akt pathways: a fine balance
E Aksamitiene, A Kiyatkin, BN Kholodenko
Biochemical Society Transactions 40 (1), 139-146, 2012
3332012
Ligand‐dependent responses of the ErbB signaling network: experimental and modeling analyses
MR Birtwistle, M Hatakeyama, N Yumoto, BA Ogunnaike, JB Hoek, ...
Molecular systems biology 3 (1), 2007
2672007
Quantitative analysis of signaling networks
HM Sauro, BN Kholodenko
Progress in biophysics and molecular biology 86 (1), 5-43, 2004
2532004
Systems‐level interactions between insulin–EGF networks amplify mitogenic signaling
N Borisov, E Aksamitiene, A Kiyatkin, S Legewie, J Berkhout, T Maiwald, ...
Molecular systems biology 5 (1), 2009
2182009
Why cytoplasmic signalling proteins should be recruited to cell membranes
BN Kholodenko, JB Hoek, HV Westerhoff
Trends in cell biology 10 (5), 173-178, 2000
2152000
Spatial gradients of cellular phospho‐proteins
GC Brown, BN Kholodenko
FEBS letters 457 (3), 452-454, 1999
2131999
The mammalian MAPK/ERK pathway exhibits properties of a negative feedback amplifier
W Sturm, O. E., Orton, R., Grindlay, J., Birtwistle, M., Vyshemirsky, V ...
Sci Signal 3 (153), ra90, 2010
2042010
Inferring dynamic architecture of cellular networks using time series of gene expression, protein and metabolite data
E Sontag, A Kiyatkin, BN Kholodenko
Bioinformatics 20 (12), 1877-1886, 2004
2012004
Ligand-specific c-Fos expression emerges from the spatiotemporal control of ErbB network dynamics
T Nakakuki, MR Birtwistle, Y Saeki, N Yumoto, K Ide, T Nagashima, ...
Cell 141 (5), 884-896, 2010
1892010
Four-dimensional organization of protein kinase signaling cascades: the roles of diffusion, endocytosis and molecular motors
BN Kholodenko
Journal of Experimental Biology 206 (12), 2073-2082, 2003
1802003
The dynamic control of signal transduction networks in cancer cells
W Kolch, M Halasz, M Granovskaya, BN Kholodenko
Nature Reviews Cancer 15 (9), 515, 2015
1792015
Quantification of information transfer via cellular signal transduction pathways
BN Kholodenko, JB Hoek, HV Westerhoff, GC Brown
FEBS letters 414 (2), 430-434, 1997
1741997
Scaffolding protein Grb2-associated binder 1 sustains epidermal growth factor-induced mitogenic and survival signaling by multiple positive feedback loops
A Kiyatkin, E Aksamitiene, NI Markevich, NM Borisov, JB Hoek, ...
Journal of biological chemistry 281 (29), 19925-19938, 2006
1672006
Computational approaches for analyzing information flow in biological networks
W Kholodenko, B., Yaffe, M. B. & Kolch
Sci. Signal. 5, re1, 2012
1512012
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