| P-Rex1, a PtdIns (3, 4, 5) P3-and Gβγ-regulated guanine-nucleotide exchange factor for Rac HCE Welch, WJ Coadwell, CD Ellson, GJ Ferguson, SR Andrews, ... Cell 108 (6), 809-821, 2002 | 669 | 2002 |
| Phosphoinositide 3-kinase-dependent activation of Rac HCE Welch, WJ Coadwell, LR Stephens, PT Hawkins FEBS letters 546 (1), 93-97, 2003 | 439 | 2003 |
| Gβγs and the Ras binding domain of p110γ are both important regulators of PI3Kγ signalling in neutrophils S Suire, AM Condliffe, GJ Ferguson, CD Ellson, H Guillou, K Davidson, ... Nature cell biology 8 (11), 1303-1309, 2006 | 221 | 2006 |
| P-Rex1 regulates neutrophil function HCE Welch, AM Condliffe, LJ Milne, GJ Ferguson, K Hill, LMC Webb, ... Current Biology 15 (20), 1867-1873, 2005 | 182 | 2005 |
| P-Rex1 is required for efficient melanoblast migration and melanoma metastasis CR Lindsay, S Lawn, AD Campbell, WJ Faller, F Rambow, RL Mort, ... Nature communications 2 (1), 555, 2011 | 180 | 2011 |
| A neutral phospholipase D activity from rat brain synaptic plasma membranes. Identification and partial characterization. V Chalifa, H Möhn, M Liscovitch Journal of Biological Chemistry 265 (29), 17512-17519, 1990 | 135 | 1990 |
| PI3K and RAC signalling in leukocyte and cancer cell migration MA Barber, HCE Welch Bulletin du cancer 93 (5), 10044-10052, 2006 | 127 | 2006 |
| Regulation of P-Rex1 by phosphatidylinositol (3, 4, 5)-trisphosphate and Gβγ subunits K Hill, S Krugmann, SR Andrews, WJ Coadwell, P Finan, HCE Welch, ... Journal of Biological Chemistry 280 (6), 4166-4173, 2005 | 125 | 2005 |
| P-Rex2, a new guanine-nucleotide exchange factor for Rac S Donald, K Hill, C Lecureuil, R Barnouin, S Krugmann, WJ Coadwell, ... FEBS letters 572 (1-3), 172-176, 2004 | 125 | 2004 |
| Protein kinase B and rac are activated in parallel within a phosphatidylinositide 3OH-kinase-controlled signaling pathway H Welch, A Eguinoa, LR Stephens, PT Hawkins Journal of Biological Chemistry 273 (18), 11248-11256, 1998 | 125 | 1998 |
| The src-family protein-tyrosine kinase p59hck is located on the secretory granules in human neutrophils and translocates towards the phagosome during cell … H Möhn, V Le Cabec, S Fischer, I Maridonneau-Parini Biochemical Journal 309 (2), 657-665, 1995 | 114 | 1995 |
| The Rac-FRET mouse reveals tight spatiotemporal control of Rac activity in primary cells and tissues AKE Johnsson, Y Dai, M Nobis, MJ Baker, EJ McGhee, S Walker, ... Cell reports 6 (6), 1153-1164, 2014 | 96 | 2014 |
| A RhoA-FRET biosensor mouse for intravital imaging in normal tissue homeostasis and disease contexts. Cell Rep 21, 274-288, 2017 | 94 | 2017 |
| Membrane translocation of P-Rex1 is mediated by G protein βγ subunits and phosphoinositide 3-kinase MA Barber, S Donald, S Thelen, KE Anderson, M Thelen, HCE Welch Journal of biological chemistry 282 (41), 29967-29976, 2007 | 91 | 2007 |
| Regulation and function of P-Rex family Rac-GEFs HCE Welch Small GTPases 6 (2), 49-70, 2015 | 90 | 2015 |
| P-Rex2 regulates Purkinje cell dendrite morphology and motor coordination S Donald, T Humby, I Fyfe, A Segonds-Pichon, SA Walker, SR Andrews, ... Proceedings of the National Academy of Sciences 105 (11), 4483-4488, 2008 | 82 | 2008 |
| P-Rex1 and Vav1 cooperate in the regulation of formyl-methionyl-leucyl-phenylalanine–dependent neutrophil responses CD Lawson, S Donald, KE Anderson, DT Patton, HCE Welch The Journal of Immunology 186 (3), 1467-1476, 2011 | 78 | 2011 |
| P-Rex and Vav Rac-GEFs in platelets control leukocyte recruitment to sites of inflammation D Pan, RT Amison, Y Riffo-Vasquez, D Spina, SJ Cleary, MJ Wakelam, ... Blood, The Journal of the American Society of Hematology 125 (7), 1146-1158, 2015 | 76 | 2015 |
| Platelets in neutrophil recruitment to sites of inflammation S Pitchford, D Pan, HCE Welch Current opinion in hematology 24 (1), 23-31, 2017 | 72 | 2017 |
| Integrin activation by P-Rex1 is required for selectin-mediated slow leukocyte rolling and intravascular crawling JM Herter, J Rossaint, H Block, H Welch, A Zarbock Blood, The Journal of the American Society of Hematology 121 (12), 2301-2310, 2013 | 62 | 2013 |
Phillip HawkinsGroup Leader, Babraham InstituteVerified email at babraham.ac.uk
