| Oscillations in NF-κB signaling control the dynamics of gene expression DE Nelson, AEC Ihekwaba, M Elliott, JR Johnson, CA Gibney, ... Science 306 (5696), 704-708, 2004 | 1484 | 2004 |
| Pulsatile stimulation determines timing and specificity of NF-κB-dependent transcription L Ashall, CA Horton, DE Nelson, P Paszek, CV Harper, K Sillitoe, S Ryan, ... Science 324 (5924), 242-246, 2009 | 658 | 2009 |
| Multi-parameter analysis of the kinetics of NF-κB signalling and transcription in single living cells G Nelson, L Paraoan, DG Spiller, GJC Wilde, MA Browne, PK Djali, ... Journal of cell science 115 (6), 1137-1148, 2002 | 145 | 2002 |
| Potent reversible inhibition of myeloperoxidase by aromatic hydroxamates LV Forbes, T Sjögren, F Auchère, DW Jenkins, B Thong, D Laughton, ... Journal of Biological Chemistry 288 (51), 36636-36647, 2013 | 115 | 2013 |
| NF-κB signalling is inhibited by glucocorticoid receptor and STAT6 via distinct mechanisms G Nelson, GJC Wilde, DG Spiller, SM Kennedy, DW Ray, E Sullivan, ... Journal of cell science 116 (12), 2495-2503, 2003 | 114 | 2003 |
| Hit-to-lead studies: the discovery of potent, orally active, thiophenecarboxamide IKK-2 inhibitors A Baxter, S Brough, A Cooper, E Floettmann, S Foster, C Harding, J Kettle, ... Bioorganic & Medicinal Chemistry Letters 14 (11), 2817-2822, 2004 | 112 | 2004 |
| Plant lectins are novel Toll-like receptor agonists J Unitt, D Hornigold Biochemical pharmacology 81 (11), 1324-1328, 2011 | 97 | 2011 |
| Direct evidence for a role of intramitochondrial Ca2+ in the regulation of oxidative phosphorylation in the stimulated rat heart. Studies using31P n.m.r. and … JF Unitt, JG McCORMACK, D Reid, LK MacLachlan, PJ England Biochemical Journal 262 (1), 293-301, 1989 | 89 | 1989 |
| Hit-to-lead studies: the discovery of potent, orally bioavailable triazolethiol CXCR2 receptor antagonists A Baxter, C Bennion, J Bent, K Boden, S Brough, A Cooper, E Kinchin, ... Bioorganic & medicinal chemistry letters 13 (16), 2625-2628, 2003 | 67 | 2003 |
| Identification of the Clinical Candidate (R)-(1-(4-Fluorophenyl)-6-((1-methyl-1H-pyrazol-4-yl)sulfonyl)-4,4a,5,6,7,8-hexahydro-1H-pyrazolo[3,4-g]isoquinolin-4a-yl … HJ Hunt, JK Belanoff, I Walters, B Gourdet, J Thomas, N Barton, J Unitt, ... Journal of Medicinal Chemistry 60 (8), 3405-3421, 2017 | 65 | 2017 |
| An evaluation of fluorescence polarization and lifetime discriminated polarization for high throughput screening of serine/threonine kinases A Fowler, D Swift, E Longman, A Acornley, P Hemsley, D Murray, J Unitt, ... Analytical biochemistry 308 (2), 223-231, 2002 | 65 | 2002 |
| Rat skeletal muscle metabolism in experimental heart failure: effects of physical training F Brunotte, CH Thompson, S Adamopoulos, A Coats, J Unitt, D Lindsay, ... Acta physiologica scandinavica 154 (4), 439-447, 1995 | 61 | 1995 |
| Hit-to-Lead studies: the discovery of potent, orally bioavailable thiazolopyrimidine CXCR2 receptor antagonists A Baxter, A Cooper, E Kinchin, K Moakes, J Unitt, A Wallace Bioorganic & medicinal chemistry letters 16 (4), 960-963, 2006 | 59 | 2006 |
| Dual D2-Receptor and β2-Adrenoceptor Agonists for the Treatment of Airway Diseases. 1. Discovery and Biological Evaluation of Some 7-(2-Aminoethyl)- 4 … RV Bonnert, RC Brown, D Chapman, DR Cheshire, J Dixon, F Ince, ... Journal of medicinal chemistry 41 (25), 4915-4917, 1998 | 58 | 1998 |
| FKBP5 mRNA expression is a biomarker for GR antagonism U Bali, T Phillips, H Hunt, J Unitt The Journal of Clinical Endocrinology & Metabolism 101 (11), 4305-4312, 2016 | 40 | 2016 |
| Determination of free creatine and phosphocreatine concentrations in the isolated perfused rat heart by 1H-and 31P-NMR JF Unitt, J Schrader, F Brunotte, GK Radda, AML Seymour Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1133 (2), 115-120, 1992 | 34 | 1992 |
| Discovery of small molecule human FPR1 receptor antagonists J Unitt, M Fagura, T Phillips, S King, M Perry, A Morley, C MacDonald, ... Bioorganic & medicinal chemistry letters 21 (10), 2991-2997, 2011 | 31 | 2011 |
| 1H-Pyrazolo [3, 4-g] hexahydro-isoquinolines as potent GR antagonists with reduced hERG inhibition and an improved pharmacokinetic profile HJ Hunt, JK Belanoff, E Golding, B Gourdet, T Phillips, D Swift, J Thomas, ... Bioorganic & Medicinal Chemistry Letters 25 (24), 5720-5725, 2015 | 29 | 2015 |
| A combinatorial biophysical approach; FTSA and SPR for identifying small molecule ligands and PAINs M Redhead, R Satchell, V Morkūnaitė, D Swift, V Petrauskas, E Golding, ... Analytical biochemistry 479, 63-73, 2015 | 28 | 2015 |
| Novel cobalt complex inhibitors of mitochondrial calcium uptake JF Unitt, KL Boden, AV Wallace, AH Ingall, ME Coombs, F Ince Bioorganic & medicinal chemistry 7 (9), 1891-1896, 1999 | 24 | 1999 |
