| Structural model of the dimeric Parkinson’s protein LRRK2 reveals a compact architecture involving distant interdomain contacts G Guaitoli, F Raimondi, BK Gilsbach, Y Gómez-Llorente, E Deyaert, ... Proceedings of the National Academy of Sciences 113 (30), E4357-E4366, 2016 | 157 | 2016 |
| Protein–protein interface-binding peptides inhibit the cancer therapy target human thymidylate synthase D Cardinale, G Guaitoli, D Tondi, R Luciani, S Henrich, OMH Salo-Ahen, ... Proceedings of the National Academy of Sciences 108 (34), E542-E549, 2011 | 103 | 2011 |
| A homologue of the Parkinson’s disease-associated protein LRRK2 undergoes a monomer-dimer transition during GTP turnover E Deyaert, L Wauters, G Guaitoli, A Konijnenberg, M Leemans, ... Nature communications 8 (1), 1008, 2017 | 64 | 2017 |
| A combinatorial approach to identify calpain cleavage sites in the Machado-Joseph disease protein ataxin-3 JJ Weber, M Golla, G Guaitoli, P Wanichawan, SN Hayer, S Hauser, ... Brain 140 (5), 1280-1299, 2017 | 46 | 2017 |
| Auto-regulation of Rab5 GEF activity in Rabex5 by allosteric structural changes, catalytic core dynamics and ubiquitin binding J Lauer, S Segeletz, A Cezanne, G Guaitoli, F Raimondi, M Gentzel, ... Elife 8, e46302, 2019 | 28 | 2019 |
| Ligand-based virtual screening and ADME-tox guided approach to identify triazolo-quinoxalines as folate cycle inhibitors E Carosati, G Sforna, M Pippi, G Marverti, A Ligabue, D Guerrieri, S Piras, ... Bioorganic & medicinal chemistry 18 (22), 7773-7785, 2010 | 27 | 2010 |
| Dimer–monomer equilibrium of human thymidylate synthase monitored by fluorescence resonance energy transfer F Genovese, S Ferrari, G Guaitoli, M Caselli, MP Costi, G Ponterini Protein Science 19 (5), 1023-1030, 2010 | 27 | 2010 |
| Inhibitor of ovarian cancer cells growth by virtual screening: a new thiazole derivative targeting human thymidylate synthase E Carosati, A Tochowicz, G Marverti, G Guaitoli, P Benedetti, S Ferrari, ... Journal of medicinal chemistry 55 (22), 10272-10276, 2012 | 22 | 2012 |
| Nanobodies as allosteric modulators of Parkinson’s disease–associated LRRK2 RK Singh, A Soliman, G Guaitoli, E Störmer, F von Zweydorf, T Dal Maso, ... Proceedings of the National Academy of Sciences 119 (9), e2112712119, 2022 | 18 | 2022 |
| Biochemical and kinetic properties of the complex Roco G-protein cycle L Wauters, S Terheyden, BK Gilsbach, M Leemans, PS Athanasopoulos, ... Biological Chemistry 399 (12), 1447-1456, 2018 | 17 | 2018 |
| Biochemical and kinetic properties of the complex Roco G-protein cycle L Wauters, S Terheyden, BK Gilsbach, M Leemans, PS Athanasopoulos, ... Biological Chemistry 399 (12), 1447-1456, 2018 | 17 | 2018 |
| First model of dimeric LRRK2: the challenge of unrevealing the structure of a multidomain Parkinson's-associated protein G Guaitoli, BK Gilsbach, F Raimondi, CJ Gloeckner Biochemical Society Transactions 44 (6), 1635-1641, 2016 | 12 | 2016 |
| Alanine mutants of the interface residues of human thymidylate synthase decode key features of the binding mode of allosteric anticancer peptides A Tochowicz, M Santucci, P Saxena, G Guaitoli, M Trande, J Finer-Moore, ... Journal of medicinal chemistry 58 (2), 1012-1018, 2015 | 12 | 2015 |
| Distamycin A and derivatives as synergic drugs in cisplatin-sensitive and-resistant ovarian cancer cells G Marverti, G Guaitoli, A Ligabue, C Frassineti, MG Monti, P Lombardi, ... Amino Acids 42, 641-653, 2012 | 11 | 2012 |
| Design and characterization of a mutation outside the active site of human thymidylate synthase that affects ligand binding D Cardinale, OMH Salo-Ahen, G Guaitoli, S Ferrari, A Venturelli, ... Protein Engineering, Design & Selection 23 (2), 81-89, 2010 | 9 | 2010 |
| Doubly Constrained C-terminal of Roc (COR) Domain-Derived Peptides Inhibit Leucine-Rich Repeat Kinase 2 (LRRK2) Dimerization P Pathak, KK Alexander, LG Helton, M Kentros, TJ LeClair, X Zhang, ... ACS chemical neuroscience 14 (11), 1971-1980, 2023 | 4 | 2023 |
| Intramolecular feedback regulation of the LRRK2 Roc G domain by a LRRK2 kinase dependent mechanism BK Gilsbach, FY Ho, B Riebenbauer, X Zhang, G Guaitoli, A Kortholt, ... BioRxiv, 2023.07. 31.549909, 2023 | 3 | 2023 |
| Biophysical analysis reveals autophosphorylation as an important negative regulator of LRRK2 dimerization G Guaitoli, X Zhang, F Saitta, P Miglionico, LM Silbermann, FY Ho, ... BioRxiv, 2023.08. 11.549911, 2023 | 2 | 2023 |
| Structural insights in the GTP-driven monomerization and activation of a bacterial LRRK2 homologue using allosteric nanobodies C Galicia, G Guaitoli, M Fislage, CJ Gloeckner, W Versées bioRxiv, 2023.11. 13.566844, 2023 | | 2023 |
| Discovery of a highly selective, orally bioavailable, brainpenetrant LRRK2 Inhibitor T Gasser, T Oprea, P Kahle, B Dahl, B Riebenbauer, F Bertoli, F Izzi, ... MOVEMENT DISORDERS 38, S7-S7, 2023 | | 2023 |
Christian Johannes Gloecknergroup leader, DZNE-German Center for Neurodegenerative Diseases (Tübingen)Verified email at dzne.de
