Ricardo M. Biondi
Ricardo M. Biondi
IBioBA, Buenos Aires, Argentina / Frankfurt University Hospital, Frankfurt, Germany
Verified email at med.uni-frankfurt.de
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A common phosphate binding site explains the unique substrate specificity of GSK3 and its inactivation by phosphorylation
S Frame, P Cohen, RM Biondi
Molecular cell 7 (6), 1321-1327, 2001
Signalling specificity of Ser/Thr protein kinases through docking-site-mediated interactions
RM Biondi, A Nebreda
Biochem. J 372, 1-13, 2003
The PIF‐binding pocket in PDK1 is essential for activation of S6K and SGK, but not PKB
RM Biondi, A Kieloch, RA Currie, M Deak, DR Alessi
The EMBO journal 20 (16), 4380-4390, 2001
Identification of a pocket in the PDK1 kinase domain that interacts with PIF and the C‐terminal residues of PKA
RM Biondi, PCF Cheung, A Casamayor, M Deak, RA Currie, DR Alessi
The EMBO journal 19 (5), 979-988, 2000
A phosphoserine/threonine‐binding pocket in AGC kinases and PDK1 mediates activation by hydrophobic motif phosphorylation
M Frödin, TL Antal, BA Dümmler, CJ Jensen, M Deak, S Gammeltoft, ...
The EMBO journal 21 (20), 5396-5407, 2002
High resolution crystal structure of the human PDK1 catalytic domain defines the regulatory phosphopeptide docking site
RM Biondi, D Komander, CC Thomas, JM Lizcano, M Deak, DR Alessi, ...
The EMBO journal 21 (16), 4219-4228, 2002
A 3-phosphoinositide-dependent protein kinase-1 (PDK1) docking site is required for the phosphorylation of protein kinase Cζ (PKCζ) and PKC-related kinase 2 by PDK1
A Balendran, RM Biondi, PCF Cheung, A Casamayor, M Deak, DR Alessi
Journal of Biological Chemistry 275 (27), 20806-20813, 2000
Differential stability of cell-free circulating microRNAs: implications for their utilization as biomarkers
V Köberle, T Pleli, C Schmithals, EA Alonso, J Haupenthal, H Bönig, ...
PloS one 8 (9), e75184, 2013
Phosphoinositide-regulated kinases and phosphoinositide phosphatases
NR Leslie, RM Biondi, DR Alessi
Chemical reviews 101 (8), 2365-2380, 2001
Epac activation converts cAMP from a proliferative into a differentiation signal in PC12 cells
S Kiermayer, RM Biondi, J Imig, G Plotz, J Haupenthal, S Zeuzem, ...
Molecular biology of the cell 16 (12), 5639-5648, 2005
AGC protein kinases: from structural mechanism of regulation to allosteric drug development for the treatment of human diseases
JM Arencibia, D Pastor-Flores, AF Bauer, JO Schulze, RM Biondi
Biochimica Et Biophysica Acta (BBA)-Proteins and Proteomics 1834 (7), 1302-1321, 2013
Phosphoinositide-dependent protein kinase 1, a sensor of protein conformation
RM Biondi
Trends in biochemical sciences 29 (3), 136-142, 2004
Mechanism for activation of the growth factor‐activated AGC kinases by turn motif phosphorylation
C Hauge, TL Antal, D Hirschberg, U Doehn, K Thorup, L Idrissova, ...
The EMBO journal 26 (9), 2251-2261, 2007
Cellular Phosphorylation of Anti-HIV Nucleosides ROLE OF NUCLEOSIDE DIPHOSPHATE KINASE
J Bourdais, R Biondi, S Sarfati, C Guerreiro, I Lascu, J Janin, M Véron
Journal of Biological Chemistry 271 (14), 7887-7890, 1996
Structure and allosteric effects of low-molecular-weight activators on the protein kinase PDK1
V Hindie, A Stroba, H Zhang, LA Lopez-Garcia, L Idrissova, S Zeuzem, ...
Nature chemical biology 5 (10), 758-764, 2009
Allosteric activation of the protein kinase PDK1 with low molecular weight compounds
M Engel, V Hindie, LA Lopez‐Garcia, A Stroba, F Schaeffer, I Adrian, ...
The EMBO Journal 25 (23), 5469-5480, 2006
3, 5-Diphenylpent-2-enoic Acids as Allosteric Activators of the Protein Kinase PDK1: Structure− Activity Relationships and Thermodynamic Characterization of Binding as …
A Stroba, F Schaeffer, V Hindie, L Lopez-Garcia, I Adrian, W Fröhner, ...
Journal of medicinal chemistry 52 (15), 4683-4693, 2009
Mutations in the MutSα interaction interface of MLH1 can abolish DNA mismatch repair
G Plotz, C Welsch, L Giron-Monzon, P Friedhoff, M Albrecht, A Piiper, ...
Nucleic acids research 34 (22), 6574-6586, 2006
Substrate-selective inhibition of protein kinase PDK1 by small compounds that bind to the PIF-pocket allosteric docking site
K Busschots, LA Lopez-Garcia, C Lammi, A Stroba, S Zeuzem, A Piiper, ...
Chemistry & biology 19 (9), 1152-1163, 2012
Allosteric regulation of protein kinase PKCζ by the N-terminal C1 domain and small compounds to the PIF-pocket
LA Lopez-Garcia, JO Schulze, W Fröhner, H Zhang, E Süß, N Weber, ...
Chemistry & biology 18 (11), 1463-1473, 2011
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