| The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1 M Komatsu, H Kurokawa, S Waguri, K Taguchi, A Kobayashi, Y Ichimura, ... Nature cell biology 12 (3), 213-223, 2010 | 2326 | 2010 |
| Molecular mechanisms of the Keap1–Nrf2 pathway in stress response and cancer evolution K Taguchi, H Motohashi, M Yamamoto Genes to cells 16 (2), 123-140, 2011 | 1648 | 2011 |
| Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming Y Mitsuishi, K Taguchi, Y Kawatani, T Shibata, T Nukiwa, H Aburatani, ... Cancer cell 22 (1), 66-79, 2012 | 1351 | 2012 |
| Keap1 degradation by autophagy for the maintenance of redox homeostasis K Taguchi, N Fujikawa, M Komatsu, T Ishii, M Unno, T Akaike, ... Proceedings of the National Academy of Sciences 109 (34), 13561-13566, 2012 | 466 | 2012 |
| The KEAP1–NRF2 system in cancer K Taguchi, M Yamamoto Frontiers in oncology 7, 85, 2017 | 449 | 2017 |
| Oxidation of proximal protein sulfhydryls by phenanthraquinone, a component of diesel exhaust particles Y Kumagai, S Koide, K Taguchi, A Endo, Y Nakai, T Yoshikawa, ... Chemical research in toxicology 15 (4), 483-489, 2002 | 368 | 2002 |
| Genetic versus chemoprotective activation of Nrf2 signaling: overlapping yet distinct gene expression profiles between Keap1 knockout and triterpenoid-treated mice MS Yates, QT Tran, PM Dolan, WO Osburn, S Shin, CC McCulloch, ... Carcinogenesis 30 (6), 1024-1031, 2009 | 316 | 2009 |
| p62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming T Saito, Y Ichimura, K Taguchi, T Suzuki, T Mizushima, K Takagi, Y Hirose, ... Nature communications 7 (1), 12030, 2016 | 298 | 2016 |
| The circadian clock regulates rhythmic activation of the NRF2/glutathione-mediated antioxidant defense pathway to modulate pulmonary fibrosis V Pekovic-Vaughan, J Gibbs, H Yoshitane, N Yang, D Pathiranage, B Guo, ... Genes & development 28 (6), 548-560, 2014 | 252 | 2014 |
| Genetic analysis of cytoprotective functions supported by graded expression of Keap1 K Taguchi, JM Maher, T Suzuki, Y Kawatani, H Motohashi, M Yamamoto Molecular and cellular biology 30 (12), 3016-3026, 2010 | 237 | 2010 |
| Nrf2-deficiency creates a responsive microenvironment for metastasis to the lung H Satoh, T Moriguchi, K Taguchi, J Takai, JM Maher, T Suzuki, ... Carcinogenesis 31 (10), 1833-1843, 2010 | 224 | 2010 |
| Genetic or pharmacologic amplification of nrf2 signaling inhibits acute inflammatory liver injury in mice WO Osburn, MS Yates, PD Dolan, S Chen, KT Liby, MB Sporn, K Taguchi, ... Toxicological Sciences 104 (1), 218-227, 2008 | 186 | 2008 |
| Ubiquitin accumulation in autophagy-deficient mice is dependent on the Nrf2-mediated stress response pathway: a potential role for protein aggregation in autophagic substrate … BE Riley, SE Kaiser, TA Shaler, ACY Ng, T Hara, MS Hipp, K Lage, ... Journal of Cell Biology 191 (3), 537-552, 2010 | 179 | 2010 |
| Deletion of nuclear factor-E2-related factor-2 leads to rapid onset and progression of nutritional steatohepatitis in mice H Sugimoto, K Okada, J Shoda, E Warabi, K Ishige, T Ueda, K Taguchi, ... American Journal of Physiology-Gastrointestinal and Liver Physiology 298 (2 …, 2010 | 171 | 2010 |
| Ursodeoxycholic acid stimulates Nrf2-mediated hepatocellular transport, detoxification, and antioxidative stress systems in mice K Okada, J Shoda, K Taguchi, JM Maher, K Ishizaki, Y Inoue, M Ohtsuki, ... American Journal of Physiology-Gastrointestinal and Liver Physiology 295 (4 …, 2008 | 161 | 2008 |
| Cytoprotective role of Nrf2/Keap1 system in methylmercury toxicity T Toyama, D Sumi, Y Shinkai, A Yasutake, K Taguchi, KI Tong, ... Biochemical and biophysical research communications 363 (3), 645-650, 2007 | 150 | 2007 |
| c‐erbB‐2 and c‐Met expression relates to cholangiocarcinogenesis and progression of intrahepatic cholangiocarcinoma SI Aishima, KI Taguchi, K Sugimachi, M Shimada, K Sugimachi, ... Histopathology 40 (3), 269-278, 2002 | 143 | 2002 |
| Critical role of Nrf2 in oxidative stress‐induced retinal ganglion cell death N Himori, K Yamamoto, K Maruyama, M Ryu, K Taguchi, M Yamamoto, ... Journal of neurochemistry 127 (5), 669-680, 2013 | 140 | 2013 |
| Primary hepatic carcinoid tumor: case report and review of 53 cases M Iwao, M Nakamuta, M Enjoji, H Kubo, T Fukutomi, Y Tanabe, H Nishi, ... Med Sci Monit 7 (4), 746-50, 2001 | 138 | 2001 |
| The KEAP1–NRF2 system as a molecular target of cancer treatment K Taguchi, M Yamamoto Cancers 13 (1), 46, 2020 | 119 | 2020 |
Motohashi HozumiInstitute of Development, Aging and Cancer, Tohoku UniversityVerified email at tohoku.ac.jp
