Hilal Lashuel
TitleCited byYear
Neurodegenerative disease: amyloid pores from pathogenic mutations
HA Lashuel, D Hartley, BM Petre, T Walz, PT Lansbury Jr
Nature 418 (6895), 291, 2002
13232002
The UCH-L1 gene encodes two opposing enzymatic activities that affect α-synuclein degradation and Parkinson's disease susceptibility
Y Liu, L Fallon, HA Lashuel, Z Liu, PT Lansbury Jr
Cell 111 (2), 209-218, 2002
8902002
α-Synuclein, especially the Parkinson's disease-associated mutants, forms pore-like annular and tubular protofibrils
HA Lashuel, BM Petre, J Wall, M Simon, RJ Nowak, T Walz, ...
Journal of molecular biology 322 (5), 1089-1102, 2002
8042002
The many faces of α-synuclein: from structure and toxicity to therapeutic target
HA Lashuel, CR Overk, A Oueslati, E Masliah
Nature Reviews Neuroscience 14 (1), 38, 2013
7572013
A century-old debate on protein aggregation and neurodegeneration enters the clinic
PT Lansbury, HA Lashuel
Nature 443 (7113), 774, 2006
6432006
Amyloidogenic protein–membrane interactions: mechanistic insight from model systems
SM Butterfield, HA Lashuel
Angewandte Chemie International Edition 49 (33), 5628-5654, 2010
4332010
Are amyloid diseases caused by protein aggregates that mimic bacterial pore-forming toxins?
HA Lashuel, PT Lansbury
Quarterly reviews of biophysics 39 (2), 167-201, 2006
4182006
α-Synuclein in central nervous system and from erythrocytes, mammalian cells, and Escherichia coli exists predominantly as disordered monomer
B Fauvet, MK Mbefo, MB Fares, C Desobry, S Michael, MT Ardah, E Tsika, ...
Journal of Biological Chemistry 287 (19), 15345-15364, 2012
3732012
Inhibiting transthyretin amyloid fibril formation via protein stabilization
GJ Miroy, Z Lai, HA Lashuel, SA Peterson, C Strang, JW Kelly
Proceedings of the National Academy of Sciences 93 (26), 15051-15056, 1996
3651996
Protofilaments, filaments, ribbons, and fibrils from peptidomimetic self-assembly: implications for amyloid fibril formation and materials science
HA Lashuel, SR LaBrenz, L Woo, LC Serpell, JW Kelly
Journal of the American Chemical Society 122 (22), 5262-5277, 2000
3142000
Mixtures of wild-type and a pathogenic (E22G) form of Aβ40 in vitro accumulate protofibrils, including amyloid pores
HA Lashuel, DM Hartley, BM Petre, JS Wall, MN Simon, T Walz, ...
Journal of molecular biology 332 (4), 795-808, 2003
2762003
Quaternary structure, protein dynamics, and synaptic function of SAP97 controlled by L27 domain interactions
T Nakagawa, K Futai, HA Lashuel, I Lo, K Okamoto, T Walz, Y Hayashi, ...
Neuron 44 (3), 453-467, 2004
2602004
Phosphorylation at Ser-129 but not the phosphomimics S129E/D inhibits the fibrillation of α-synuclein
KE Paleologou, AW Schmid, CC Rospigliosi, HY Kim, GR Lamberto, ...
Journal of Biological Chemistry 283 (24), 16895-16905, 2008
2592008
Role of post-translational modifications in modulating the structure, function and toxicity of α-synuclein: implications for Parkinson’s disease pathogenesis and therapies
A Oueslati, M Fournier, HA Lashuel
Progress in brain research 183, 115-145, 2010
2492010
Inhibiting transthyretin conformational changes that lead to amyloid fibril formation
SA Peterson, T Klabunde, HA Lashuel, H Purkey, JC Sacchettini, JW Kelly
Proceedings of the National Academy of Sciences 95 (22), 12956-12960, 1998
2331998
Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cell line
Y Liu, HA Lashuel, S Choi, X Xing, A Case, J Ni, LA Yeh, GD Cuny, ...
Chemistry & biology 10 (9), 837-846, 2003
2302003
The ratio of monomeric to aggregated forms of Aβ40 and Aβ42 is an important determinant of amyloid-β aggregation, fibrillogenesis, and toxicity
A Jan, O Gokce, R Luthi-Carter, HA Lashuel
Journal of Biological Chemistry 283 (42), 28176-28189, 2008
2262008
Phosphorylation at S87 is enhanced in synucleinopathies, inhibits α-synuclein oligomerization, and influences synuclein-membrane interactions
KE Paleologou, A Oueslati, G Shakked, CC Rospigliosi, HY Kim, ...
Journal of Neuroscience 30 (9), 3184-3198, 2010
2242010
Characterization of the transthyretin acid denaturation pathways by analytical ultracentrifugation: implications for wild-type, V30M, and L55P amyloid fibril formation
HA Lashuel, Z Lai, JW Kelly
Biochemistry 37 (51), 17851-17864, 1998
2231998
The impact of the E46K mutation on the properties of α-synuclein in its monomeric and oligomeric states
RA Fredenburg, C Rospigliosi, RK Meray, JC Kessler, HA Lashuel, ...
Biochemistry 46 (24), 7107-7118, 2007
2082007
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