Dr. Youcef Mehellou
Dr. Youcef Mehellou
Verified email at cardiff.ac.uk - Homepage
Cited by
Cited by
Twenty-six years of anti-HIV drug discovery: where do we stand and where do we go?
Y Mehellou, E De Clercq
Journal of medicinal chemistry 53 (2), 521-538, 2010
Aryloxy phosphoramidate triesters: a technology for delivering monophosphorylated nucleosides and sugars into cells
Y Mehellou, J Balzarini, C McGuigan
ChemMedChem: Chemistry Enabling Drug Discovery 4 (11), 1779-1791, 2009
The CUL3–KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt …
A Ohta, FR Schumacher, Y Mehellou, C Johnson, A Knebel, TJ Macartney, ...
Biochemical Journal 451 (1), 111-122, 2013
MO25 is a master regulator of SPAK/OSR1 and MST3/MST4/YSK1 protein kinases
BM Filippi, P De Los Heros, Y Mehellou, I Navratilova, R Gourlay, M Deak, ...
The EMBO journal 30 (9), 1730-1741, 2011
SPAK/OSR1 regulate NKCC1 and WNK activity: analysis of WNK isoform interactions and activation by T-loop trans-autophosphorylation
JO Thastrup, FH Rafiqi, AC Vitari, E Pozo-Guisado, M Deak, Y Mehellou, ...
Biochemical Journal 441 (1), 325-337, 2012
The ProTide Prodrug Technology: From the Concept to the Clinic: Miniperspective
Y Mehellou, HS Rattan, J Balzarini
Journal of medicinal chemistry 61 (6), 2211-2226, 2017
Nucleoside phosphate and phosphonate prodrug clinical candidates: Miniperspective
PJ Thornton, H Kadri, A Miccoli, Y Mehellou
Journal of Medicinal Chemistry 59 (23), 10400-10410, 2016
Organometallic nucleoside analogues with ferrocenyl linker groups: synthesis and cancer cell line studies
HV Nguyen, A Sallustrau, J Balzarini, MR Bedford, JC Eden, N Georgousi, ...
Journal of medicinal chemistry 57 (13), 5817-5822, 2014
Phosphoramidates of 2′-β-d-arabinouridine (AraU) as phosphate prodrugs; design, synthesis, in vitro activity and metabolism
Y Mehellou, R Valente, H Mottram, E Walsby, KI Mills, J Balzarini, ...
Bioorganic & medicinal chemistry 18 (7), 2439-2446, 2010
An investigation into the anti-HIV activity of 2′, 3′-didehydro-2′, 3′-dideoxyuridine (d4U) and 2′, 3′-dideoxyuridine (ddU) phosphoramidate ‘ProTide’derivatives
Y Mehellou, J Balzarini, C McGuigan
Organic & Biomolecular Chemistry 7 (12), 2548-2553, 2009
Kinetin riboside and its ProTides activate the Parkinson’s disease associated PTEN-induced putative kinase 1 (PINK1) independent of mitochondrial depolarization
L Osgerby, YC Lai, PJ Thornton, J Amalfitano, CS Le Duff, I Jabeen, ...
Journal of medicinal chemistry 60 (8), 3518-3524, 2017
Design, synthesis, and anti-HIV activity of 2′, 3′-didehydro-2′, 3′-dideoxyuridine (d4U), 2′, 3′-dideoxyuridine (ddU) phosphoramidate ‘ProTide’derivatives
Y Mehellou, C McGuigan, A Brancale, J Balzarini
Bioorganic & medicinal chemistry letters 17 (13), 3666-3669, 2007
BTN3A1 Discriminates γδ T Cell Phosphoantigens from Nonantigenic Small Molecules via a Conformational Sensor in Its B30.2 Domain
M Salim, TJ Knowles, AT Baker, MS Davey, M Jeeves, P Sridhar, J Wilkie, ...
ACS chemical biology 12 (10), 2631-2643, 2017
The protides boom
Y Mehellou
ChemMedChem 11 (11), 1114, 2016
Structural insights into the activation of MST3 by MO25
Y Mehellou, DR Alessi, TJ Macartney, M Szklarz, S Knapp, JM Elkins
Biochemical and biophysical research communications 431 (3), 604-609, 2013
Rafoxanide and Closantel Inhibit SPAK and OSR1 Kinases by Binding to a Highly Conserved Allosteric Site on Their C‐terminal Domains
MA AlAmri, H Kadri, LJ Alderwick, NS Simpkins, Y Mehellou
ChemMedChem 12 (9), 639-645, 2017
The ProTide prodrug technology: where next?
AS Alanazi, E James, Y Mehellou
ACS Medicinal Chemistry Letters 10 (1), 2-5, 2018
The anthelmintic drug niclosamide and its analogues activate the Parkinson's disease associated protein kinase PINK1
E Barini, A Miccoli, F Tinarelli, K Mulholland, H Kadri, F Khanim, ...
ChemBioChem 19 (5), 425-429, 2018
Synthesis and Biological Evaluation of (E)-4-Hydroxy-3-methylbut-2-enyl Phosphate (HMBP) Aryloxy Triester Phosphoramidate Prodrugs as Activators of Vγ9/Vδ2 …
MS Davey, R Malde, RC Mykura, AT Baker, TE Taher, CS Le Duff, ...
Journal of medicinal chemistry 61 (5), 2111-2117, 2018
Organometallic nucleoside analogues: effect of hydroxyalkyl linker length on cancer cell line toxicity
JL Kedge, HV Nguyen, Z Khan, L Male, SL Horswell, Y Mehellou, ...
European Journal of Inorganic Chemistry 2017 (2), 466-476, 2017
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