Sridhar Natesan
Sridhar Natesan
Senior Researcher, Institute of Psychiatry, Psychology and Neuroscience, King's College London
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Dissociation between in vivo occupancy and functional antagonism of dopamine D 2 receptors: comparing aripiprazole to other antipsychotics in animal models
S Natesan, GE Reckless, JN Nobrega, PJ Fletcher, S Kapur
Neuropsychopharmacology 31 (9), 1854-1863, 2006
Should psychiatrists be more cautious about the long-term prophylactic use of antipsychotics?
RM Murray, D Quattrone, S Natesan, J van Os, M Nordentoft, O Howes, ...
The British Journal of Psychiatry 209 (5), 361-365, 2016
Effect of chronic antipsychotic treatment on brain structure: a serial magnetic resonance imaging study with ex vivo and postmortem confirmation
AC Vernon, S Natesan, M Modo, S Kapur
Biological psychiatry 69 (10), 936-944, 2011
Contrasting effects of haloperidol and lithium on rodent brain structure: a magnetic resonance imaging study with postmortem confirmation
AC Vernon, S Natesan, WR Crum, JD Cooper, M Modo, SCR Williams, ...
Biological psychiatry 71 (10), 855-863, 2012
Comparative effects of 18 antipsychotics on metabolic function in patients with schizophrenia, predictors of metabolic dysregulation, and association with psychopathology: a …
T Pillinger, RA McCutcheon, L Vano, Y Mizuno, A Arumuham, G Hindley, ...
The Lancet Psychiatry 7 (1), 64-77, 2020
Reduced cortical volume and elevated astrocyte density in rats chronically treated with antipsychotic drugs—linking magnetic resonance imaging findings to cellular pathology
AC Vernon, WR Crum, JP Lerch, W Chege, S Natesan, M Modo, ...
Biological psychiatry 75 (12), 982-990, 2014
The dopamine stabilizers (S)-(-)-(3-methanesulfonyl-phenyl)-1-propyl-piperidine [(-)-OSU6162] and 4-(3-methanesulfonylphenyl)-1-propyl-piperidine (ACR16) show high in vivo D2 …
S Natesan, KA Svensson, GE Reckless, JN Nobrega, KBL Barlow, ...
Journal of Pharmacology and Experimental Therapeutics 318 (2), 810-818, 2006
Loss of phosphodiesterase 10A expression is associated with progression and severity in Parkinson’s disease
F Niccolini, T Foltynie, T Reis Marques, N Muhlert, AC Tziortzi, GE Searle, ...
Brain 138 (10), 3003-3015, 2015
Altered PDE10A expression detectable early before symptomatic onset in Huntington’s disease
F Niccolini, S Haider, T Reis Marques, N Muhlert, AC Tziortzi, GE Searle, ...
Brain 138 (10), 3016-3029, 2015
Amisulpride the ‘atypical’atypical antipsychotic—comparison to haloperidol, risperidone and clozapine
S Natesan, GE Reckless, KBL Barlow, JN Nobrega, S Kapur
Schizophrenia research 105 (1-3), 224-235, 2008
Microglial activation in the rat brain following chronic antipsychotic treatment at clinically relevant doses
MC Cotel, EM Lenartowicz, S Natesan, MM Modo, JD Cooper, ...
European Neuropsychopharmacology 25 (11), 2098-2107, 2015
The antipsychotic potential of l-stepholidine—a naturally occurring dopamine receptor D 1 agonist and D 2 antagonist
S Natesan, GE Reckless, KBL Barlow, J Odontiadis, JN Nobrega, ...
Psychopharmacology 199 (2), 275-289, 2008
Phosphodiesterase 10A PET radioligand development program: from pig to human
C Plisson, D Weinzimmer, S Jakobsen, S Natesan, C Salinas, SF Lin, ...
Journal of Nuclear Medicine 55 (4), 595-601, 2014
Evaluation of N-desmethylclozapine as a potential antipsychotic—preclinical studies
S Natesan, GE Reckless, KBL Barlow, JN Nobrega, S Kapur
Neuropsychopharmacology 32 (7), 1540-1549, 2007
Antipsychotics: mechanisms underlying clinical response and side-effects and novel treatment approaches based on pathophysiology
SJ Kaar, S Natesan, R McCutcheon, OD Howes
Neuropharmacology 172, 107704, 2020
Dynamic regulation of dopamine and serotonin responses to salient stimuli during chronic haloperidol treatment
D Amato, S Natesan, L Yavich, S Kapur, CP Müller
International Journal of Neuropsychopharmacology 14 (10), 1327-1339, 2011
Synaptic density marker SV2A is reduced in schizophrenia patients and unaffected by antipsychotics in rats
EC Onwordi, EF Halff, T Whitehurst, A Mansur, MC Cotel, L Wells, ...
Nature communications 11 (1), 1-11, 2020
Partial agonists in schizophrenia–why some work and others do not: insights from preclinical animal models
S Natesan, GE Reckless, KBL Barlow, JN Nobrega, S Kapur
International Journal of Neuropsychopharmacology 14 (9), 1165-1178, 2011
The effects of antipsychotic treatment on presynaptic dopamine synthesis capacity in first-episode psychosis: a positron emission tomography study
S Jauhar, M Veronese, MM Nour, M Rogdaki, P Hathway, S Natesan, ...
Biological psychiatry 85 (1), 79-87, 2019
Regulation of dopaminergic function: an [18 F]-DOPA PET apomorphine challenge study in humans.
S Jauhar, M Veronese, M Rogdaki, M Bloomfield, S Natesan, ...
Translational psychiatry 7 (2), e1027-e1027, 2017
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