Stephen Douthwaite

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Roger A GarrettProfessor Emeritus, Archaea Centre, Department of Biology,, Copenhagen UniversityVerified email at bio.ku.dk
Alexander MankinUniversity of Illinois at ChicagpVerified email at uic.edu
Janusz BujnickiProfessor of Biology, International Institute of Molecular and Cell Biology in WarsawVerified email at iimcb.gov.pl
Gilles van WezelLeiden University; NIOO-KNAWVerified email at biology.leidenuniv.nl
Danesh MoazedProfessor of Cell Biology, Harvard Medical SchoolVerified email at hms.harvard.edu
David J FarrellDirector of Bacteriology, Saskatchewan Disease Control LaboratoryVerified email at health.gov.sk.ca
Belen GutierrezPhD student, Universidad Complutense de MadridVerified email at vet.ucm.es
Anders Liljasprofessor i molekylär biofysikVerified email at liljas.net
Mashal Almutairi, Ph.D.King Saud University, College of Pharmacy, Department of PharmacologyVerified email at ksu.edu.sa
Kam D. DahlquistProfessor of Biology, Loyola Marymount UniversityVerified email at lmu.edu
Guy Wayne NovotnyRigshospitalet, Klinisk Genetisk afdelingVerified email at runbox.com
Jan ChristiansenVerified email at bio.ku.dk
Gordana Maravic VlahovicekAssociate Professor of Molecular Biology, University of Zagreb Faculty of Pharmacy and BiochemistryVerified email at pharma.unizg.hr
Jean-Luc PERNODETUniversité Paris-Saclay Institute for Integrative Biology of the Cell (I2BC)Verified email at u-psud.fr
Robin R. GutellProfessor, Department of Integrative Biology, University of Texas at AustinVerified email at austin.utexas.edu
Toni GabaldonGroup Leader, Institute for Research in Biomedicine (IRB), Barcelona Supercomputing Centre (BSC)Verified email at crg.es
Alfonso Benítez-Páez (ORCID: 0000-0...Institute of Agrochemistry and Food Technology (IATA-CSIC)Verified email at iata.csic.es
Martin HällbergGroup leader, Department of Cell and Molecular Biology, Karolinska InstitutetVerified email at ki.se
Sivaraman JNational University of SingaporeVerified email at nus.edu.sg
Nelson Enrique Arenas SuarezUniversidad de CartagenaVerified email at unicartagena.edu.co

Stephen Douthwaite

Professor of Molecular Microbiology, University of Southern Denmark

Verified email at bmb.sdu.dk

antibiotics


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Macrolide resistance conferred by base substitutions in 23S rRNA B Vester, S Douthwaite Antimicrobial agents and chemotherapy 45 (1), 1-12, 2001	730	2001
The bacterial ribosome as a target for antibiotics J Poehlsgaard, S Douthwaite Nature Reviews Microbiology 3 (11), 870-881, 2005	729	2005
The macrolide–ketolide antibiotic binding site is formed by structures in domains II and V of 23S ribosomal RNA LH Hansen, P Mauvais, S Douthwaite Molecular microbiology 31 (2), 623-631, 1999	389	1999
Capreomycin binds across the ribosomal subunit interface using tlyA-encoded 2′-O-methylations in 16S and 23S rRNAs SK Johansen, CE Maus, BB Plikaytis, S Douthwaite Molecular cell 23 (2), 173-182, 2006	338	2006
Basis for prokaryotic specificity of action of aminoglycoside antibiotics MI Recht, S Douthwaite, JD Puglisi The EMBO journal, 1999	327	1999
The ketolides: a critical review GG Zhanel, M Walters, A Noreddin, LM Vercaigne, A Wierzbowski, ... Drugs 62, 1771-1804, 2002	252	2002
Macrolide–ketolide inhibition of MLS‐resistant ribosomes is improved by alternative drug interaction with domain II of 23S rRNA S Douthwaite, LH Hansen, P Mauvais Molecular microbiology 36 (1), 183-193, 2000	242	2000
Oxazolidinone Resistance Mutations in 23S rRNA of Escherichia coli Reveal the Central Region of Domain V as the Primary Site of Drug Action L Xiong, P Kloss, S Douthwaite, NM Andersen, S Swaney, ... Journal of bacteriology 182 (19), 5325-5331, 2000	230	2000
A “bulged” double helix in a RNA-protein contact site DA Peattie, S Douthwaite, RA Garrett, HF and Noller Proc. Natl. Acad. Sci. USA 78, 7331-7335, 1981	193	1981
LNAzymes: incorporation of LNA-type monomers into DNAzymes markedly increases RNA cleavage B Vester, LB Lundberg, MD Sørensen, BR Babu, S Douthwaite, J Wengel Journal of the American Chemical Society 124 (46), 13682-13683, 2002	171	2002
Structures of ketolides and macrolides determine their mode of interaction with the ribosomal target site S Douthwaite, WS Champney Journal of Antimicrobial Chemotherapy 48 (suppl_2), 1-8, 2001	163	2001
Characterization of the binding sites of protein L11 and the L10.(L12) 4 pentameric complex in the GTPase domain of 23 S ribosomal RNA from Escherichia coli J Egebjerg, SR Douthwaite, A Liljas, RA Garrett Journal of molecular biology 213 (2), 275-288, 1990	160	1990
The antibiotics micrococcin and thiostrepton interact directly with 23S rRNA nucleotides 1067A and 1095A G Rosendahl, S Douthwaite Nucleic acids research 22 (3), 357-363, 1994	155	1994
Mapping posttranscriptional modifications in 5S ribosomal RNA by MALDI mass spectrometry. F Kirpekar, S Douthwaite, P Roepstorff RNA 6 (2), 296-306, 2000	149	2000
Macrolide Resistance by Ribosomal Mutation in Clinical Isolates of Streptococcus pneumoniae from the PROTEKT 1999-2000 Study DJ Farrell, S Douthwaite, I Morrissey, S Bakker, J Poehlsgaard, ... Antimicrobial agents and chemotherapy 47 (6), 1777-1783, 2003	146	2003
Interconversion of active and inactive 30 S ribosomal subunits is accompanied by a conformational change in the decoding region of 16 S rRNA D Moazed, BJ Van Stolk, S Douthwaite, HF Noller Journal of molecular biology 191 (3), 483-493, 1986	145	1986
Effect of mutations in the A site of 16 S rRNA on aminoglycoside antibiotic-ribosome interaction MI Recht, S Douthwaite, KD Dahlquist, JD Puglisi Journal of molecular biology 286 (1), 33-43, 1999	140	1999
YebU is a m5C methyltransferase specific for 16S rRNA nucleotide 1407 NM Andersen, S Douthwaite Journal of molecular biology 359 (3), 777-786, 2006	139	2006
Association of the novel aminoglycoside resistance determinant RmtF with NDM carbapenemase in Enterobacteriaceae isolated in India and the UK L Hidalgo, KL Hopkins, B Gutierrez, CM Ovejero, S Shukla, S Douthwaite, ... Journal of Antimicrobial Chemotherapy 68, 1543-1550, 2013	133	2013
Activity of the ketolide telithromycin is refractory to Erm monomethylation of bacterial rRNA M Liu, S Douthwaite Antimicrobial Agents and Chemotherapy 46 (6), 1629-1633, 2002	129	2002

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