Structure of the tetrameric restriction endonuclease NgoMIV in complex with cleaved DNA M Deibert, S Grazulis, G Sasnauskas, V Siksnys, R Huber nature structural biology 7 (9), 792-799, 2000 | 200 | 2000 |
Novel Subtype of Type IIs Restriction Enzymes: BfiI endonuclease exhibits similarities to the EDTA-resistant nuclease Nuc of Salmonella typhimurium R Sapranauskas, G Sasnauskas, A Lagunavicius, G Vilkaitis, A Lubys, ... Journal of Biological Chemistry 275 (40), 30878-30885, 2000 | 119 | 2000 |
The Cfr10I restriction enzyme is functional as a tetramer V Siksnys, R Skirgaila, G Sasnauskas, C Urbanke, D Cherny, S Grazulis, ... Journal of molecular biology 291 (5), 1105-1118, 1999 | 105 | 1999 |
Generation and characterization of new highly thermostable and processive M-MuLV reverse transcriptase variants A Baranauskas, S Paliksa, G Alzbutas, M Vaitkevicius, J Lubiene, ... Protein Engineering, Design & Selection 25 (10), 657-668, 2012 | 85 | 2012 |
The metal-independent type IIs restriction enzyme BfiI is a dimer that binds two DNA sites but has only one catalytic centre A Lagunavicius, G Sasnauskas, SE Halford, V Siksnys Journal of molecular biology 326 (4), 1051-1064, 2003 | 80 | 2003 |
Crystal structure of the Bse634I restriction endonuclease: comparison of two enzymes recognizing the same DNA sequence S Grazulis, M Deibert, R Rimseliene, R Skirgaila, G Sasnauskas, ... Nucleic acids research 30 (4), 876-885, 2002 | 72 | 2002 |
How the BfiI restriction enzyme uses one active site to cut two DNA strands G Sasnauskas, SE Halford, V Siksnys Proceedings of the National Academy of Sciences 100 (11), 6410-6415, 2003 | 68 | 2003 |
TnpB structure reveals minimal functional core of Cas12 nuclease family G Sasnauskas, G Tamulaitiene, G Druteika, A Carabias, A Silanskas, ... Nature 616 (7956), 384-389, 2023 | 52 | 2023 |
Conversion of the tetrameric restriction endonuclease Bse634I into a dimer: oligomeric structure–stability–function correlations M Zaremba, G Sasnauskas, C Urbanke, V Siksnys Journal of molecular biology 348 (2), 459-478, 2005 | 46 | 2005 |
A novel mechanism for the scission of double-stranded DNA: BfiI cuts both 3′–5′ and 5′–3′ strands by rotating a single active site G Sasnauskas, L Zakrys, M Zaremba, R Cosstick, JW Gaynor, SE Halford, ... Nucleic acids research 38 (7), 2399-2410, 2010 | 43 | 2010 |
Plasmid DNA Cleavage by MunI Restriction Enzyme: Single-Turnover and Steady-State Kinetic Analysis G Sasnauskas, A Jeltsch, A Pingoud, V Siksnys Biochemistry 38 (13), 4028-4036, 1999 | 40 | 1999 |
HEPN-MNT toxin-antitoxin system: the HEPN ribonuclease is neutralized by OligoAMPylation I Songailiene, J Juozapaitis, G Tamulaitiene, A Ruksenaite, S Šulčius, ... Molecular cell 80 (6), 955-970. e7, 2020 | 38 | 2020 |
Simultaneous binding of three recognition sites is necessary for a concerted plasmid DNA cleavage by EcoRII restriction endonuclease G Tamulaitis, G Sasnauskas, M Mucke, V Siksnys Journal of molecular biology 358 (2), 406-419, 2006 | 37 | 2006 |
CRISPR adaptation from a structural perspective G Sasnauskas, V Siksnys Current Opinion in Structural Biology 65, 17-25, 2020 | 35 | 2020 |
Tetrameric restriction enzymes: expansion to the GIY-YIG nuclease family G Gasiunas, G Sasnauskas, G Tamulaitis, C Urbanke, D Razaniene, ... Nucleic acids research 36 (3), 938-949, 2008 | 34 | 2008 |
DNA synapsis through transient tetramerization triggers cleavage by Ecl18kI restriction enzyme M Zaremba, A Owsicka, G Tamulaitis, G Sasnauskas, LS Shlyakhtenko, ... Nucleic acids research 38 (20), 7142-7154, 2010 | 32 | 2010 |
Structural basis of DNA target recognition by the B3 domain of Arabidopsis epigenome reader VAL1 G Sasnauskas, K Kauneckaitė, V Siksnys Nucleic acids research 46 (8), 4316-4324, 2018 | 31 | 2018 |
Site-specific DNA transesterification catalyzed by a restriction enzyme G Sasnauskas, BA Connolly, SE Halford, V Siksnys Proceedings of the National Academy of Sciences 104 (7), 2115-2120, 2007 | 30 | 2007 |
Structural insight into the specificity of the B3 DNA-binding domains provided by the co-crystal structure of the C-terminal fragment of BfiI restriction enzyme D Golovenko, E Manakova, L Zakrys, M Zaremba, G Sasnauskas, ... Nucleic Acids Research 42 (6), 4113-4122, 2014 | 27 | 2014 |
Target site cleavage by the monomeric restriction enzyme BcnI requires translocation to a random DNA sequence and a switch in enzyme orientation G Sasnauskas, G Kostiuk, G Tamulaitis, V Siksnys Nucleic acids research 39 (20), 8844-8856, 2011 | 25 | 2011 |