| The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1 Y Sancak, TR Peterson, YD Shaul, RA Lindquist, CC Thoreen, ... Science 320 (5882), 1496-1501, 2008 | 3077 | 2008 |
| Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids Y Sancak, L Bar-Peled, R Zoncu, AL Markhard, S Nada, DM Sabatini Cell 141 (2), 290-303, 2010 | 2650 | 2010 |
| mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H+-ATPase R Zoncu, L Bar-Peled, A Efeyan, S Wang, Y Sancak, DM Sabatini Science 334 (6056), 678-683, 2011 | 1801 | 2011 |
| A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1 L Bar-Peled, L Chantranupong, AD Cherniack, WW Chen, KA Ottina, ... Science 340 (6136), 1100-1106, 2013 | 1155 | 2013 |
| Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1 L Bar-Peled, LD Schweitzer, R Zoncu, DM Sabatini Cell 150 (6), 1196-1208, 2012 | 1033 | 2012 |
| Regulation of mTORC1 by amino acids L Bar-Peled, DM Sabatini Trends in cell biology 24 (7), 400-406, 2014 | 864 | 2014 |
| Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1 S Wang, ZY Tsun, RL Wolfson, K Shen, GA Wyant, ME Plovanich, ... Science 347 (6218), 188-194, 2015 | 813 | 2015 |
| The folliculin tumor suppressor is a GAP for the RagC/D GTPases that signal amino acid levels to mTORC1 ZY Tsun, L Bar-Peled, L Chantranupong, R Zoncu, T Wang, C Kim, ... Molecular cell 52 (4), 495-505, 2013 | 568 | 2013 |
| The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1 L Chantranupong, RL Wolfson, JM Orozco, RA Saxton, SM Scaria, ... Cell reports 9 (1), 1-8, 2014 | 452 | 2014 |
| Clinical Acquired Resistance to KRASG12C Inhibition through a Novel KRAS Switch-II Pocket Mutation and Polyclonal Alterations Converging on RAS–MAPK … N Tanaka, JJ Lin, C Li, MB Ryan, J Zhang, LA Kiedrowski, AG Michel, ... Cancer discovery 11 (8), 1913-1922, 2021 | 285 | 2021 |
| Chemical proteomics identifies druggable vulnerabilities in a genetically defined cancer L Bar-Peled, EK Kemper, RM Suciu, EV Vinogradova, KM Backus, ... Cell 171 (3), 696-709. e23, 2017 | 220 | 2017 |
| Lysosome: The metabolic signaling hub DW Lamming, L Bar‐Peled Traffic 20 (1), 27-38, 2019 | 144 | 2019 |
| Identification of galacturonic acid-1-phosphate kinase, a new member of the GHMP kinase superfamily in plants, and comparison with galactose-1-phosphate kinase T Yang, L Bar-Peled, L Gebhart, SG Lee, M Bar-Peled Journal of biological chemistry 284 (32), 21526-21535, 2009 | 64 | 2009 |
| Translation attenuation by minocycline enhances longevity and proteostasis in old post-stress-responsive organisms GM Solis, R Kardakaris, ER Valentine, L Bar-Peled, AL Chen, MM Blewett, ... Elife 7, e40314, 2018 | 47 | 2018 |
| SnapShot: mTORC1 signaling at the lysosomal surface L Bar-Peled, DM Sabatini Cell 151 (6), 1390-1390. e1, 2012 | 46 | 2012 |
| Disruption of the rag-ragulator complex by c17orf59 inhibits mTORC1 LD Schweitzer, WC Comb, L Bar-Peled, DM Sabatini Cell reports 12 (9), 1445-1455, 2015 | 42 | 2015 |
| Pharmacological convergence reveals a lipid pathway that regulates C. elegans lifespan AL Chen, KM Lum, P Lara-Gonzalez, D Ogasawara, AB Cognetta III, A To, ... Nature chemical biology 15 (5), 453-462, 2019 | 40 | 2019 |
| NRF2 activation induces NADH-reductive stress, providing a metabolic vulnerability in lung cancer T Weiss-Sadan, M Ge, M Hayashi, M Gohar, CH Yao, A de Groot, S Harry, ... Cell metabolism 35 (3), 487-503. e7, 2023 | 35 | 2023 |
| Systematic identification of anticancer drug targets reveals a nucleus-to-mitochondria ROS-sensing pathway J Zhang, CM Simpson, J Berner, HB Chong, J Fang, Z Ordulu, ... Cell 186 (11), 2361-2379. e25, 2023 | 34 | 2023 |
| An MXD1-derived repressor peptide identifies noncoding mediators of MYC-driven cell proliferation P Raffeiner, JR Hart, D García-Caballero, L Bar-Peled, MS Weinberg, ... Proceedings of the National Academy of Sciences 117 (12), 6571-6579, 2020 | 34 | 2020 |
