Martin McMahon
Martin McMahon
Cumming-Presidential Professor of Cancer Biology, Huntsman Cancer Institute, Univ. of Utah
Verified email at
TitleCited byYear
Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis
SP Thayer, MP di Magliano, PW Heiser, CM Nielsen, DJ Roberts, ...
Nature 425 (6960), 851, 2003
Differential activation of ERK and JNK mitogen-activated protein kinases by Raf-1 and MEKK
A Minden, A Lin, M McMahon, C Lange-Carter, B Derijard, RJ Davis, ...
Science 266 (5191), 1719-1723, 1994
BrafV600E cooperates with Pten loss to induce metastatic melanoma
D Dankort, DP Curley, RA Cartlidge, B Nelson, AN Karnezis, ...
Nature genetics 41 (5), 544, 2009
Senescence of human fibroblasts induced by oncogenic Raf
J Zhu, D Woods, M McMahon, JM Bishop
Genes & development 12 (19), 2997-3007, 1998
Transcriptional and posttranscriptional regulation of interferon-induced gene expression in human cells
RL Friedman, SP Manly, M McMahon, IM Kerr, GR Stark
Cell 38 (3), 745-755, 1984
Raf-induced proliferation or cell cycle arrest is determined by the level of Raf activity with arrest mediated by p21Cip1.
D Woods, D Parry, H Cherwinski, E Bosch, E Lees, M McMahon
Molecular and cellular biology 17 (9), 5598-5611, 1997
Modelling vemurafenib resistance in melanoma reveals a strategy to forestall drug resistance
MD Thakur, F Salangsang, AS Landman, WR Sellers, NK Pryer, ...
Nature 494 (7436), 251, 2013
Identification and characterization of a constitutively active STAT5 mutant that promotes cell proliferation
M Onishi, T Nosaka, K Misawa, ALF Mui, D Gorman, M McMahon, ...
Molecular and cellular biology 18 (7), 3871-3879, 1998
Targeting RAF kinases for cancer therapy: BRAF-mutated melanoma and beyond
M Holderfield, MM Deuker, F McCormick, M McMahon
Nature Reviews Cancer 14 (7), 455, 2014
A new mouse model to explore the initiation, progression, and therapy of BRAFV600E-induced lung tumors
D Dankort, E Filenova, M Collado, M Serrano, K Jones, M McMahon
Genes & development 21 (4), 379-384, 2007
Opposing effects of Ras on p53: transcriptional activation of mdm2 and induction of p19ARF
S Ries, C Biederer, D Woods, O Shifman, S Shirasawa, T Sasazuki, ...
Cell 103 (2), 321-330, 2000
Conditional transformation of cells and rapid activation of the mitogen-activated protein kinase cascade by an estradiol-dependent human raf-1 protein kinase.
ML Samuels, MJ Weber, JM Bishop, M McMahon
Molecular and cellular biology 13 (10), 6241-6252, 1993
The RET/PTC-RAS-BRAF linear signaling cascade mediates the motile and mitogenic phenotype of thyroid cancer cells
RM Melillo, MD Castellone, V Guarino, V De Falco, AM Cirafici, ...
The Journal of clinical investigation 115 (4), 1068-1081, 2005
An ultraviolet-radiation-independent pathway to melanoma carcinogenesis in the red hair/fair skin background
D Mitra, X Luo, A Morgan, J Wang, MP Hoang, J Lo, CR Guerrero, ...
Nature 491 (7424), 449, 2012
Raf induces TGFβ production while blocking its apoptotic but not invasive responses: a mechanism leading to increased malignancy in epithelial cells
K Lehmann, E Janda, CE Pierreux, M Rytömaa, A Schulze, M McMahon, ...
Genes & development 14 (20), 2610-2622, 2000
Analysis of the transcriptional program induced by Raf in epithelial cells
A Schulze, K Lehmann, HBJ Jefferies, M McMahon, J Downward
Genes & development 15 (8), 981-994, 2001
Keap1 perceives stress via three sensors for the endogenous signaling molecules nitric oxide, zinc, and alkenals
M McMahon, DJ Lamont, KA Beattie, JD Hayes
Proceedings of the National Academy of Sciences 107 (44), 18838-18843, 2010
Conditionally oncogenic forms of the A-Raf and B-Raf protein kinases display different biological and biochemical properties in NIH 3T3 cells.
CA Pritchard, ML Samuels, E Bosch, M McMahon
Molecular and cellular biology 15 (11), 6430-6442, 1995
β-catenin signaling controls metastasis in Braf-activated Pten-deficient melanomas
WE Damsky, DP Curley, M Santhanakrishnan, LE Rosenbaum, JT Platt, ...
Cancer cell 20 (6), 741-754, 2011
Cooperating oncogenes converge to regulate cyclin/cdk complexes.
AC Lloyd, F Obermüller, S Staddon, CF Barth, M McMahon, H Land
Genes & development 11 (5), 663-677, 1997
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