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Frank Narjes
Frank Narjes
Senior Principal Scientist, Medicinal Chemistry, AstraZeneca AB
Verified email at astrazeneca.com
Title
Cited by
Cited by
Year
Mechanism of action and antiviral activity of benzimidazole-based allosteric inhibitors of the hepatitis C virus RNA-dependent RNA polymerase
L Tomei, S Altamura, L Bartholomew, A Biroccio, A Ceccacci, L Pacini, ...
Journal of Virology 77 (24), 13225-13231, 2003
2412003
Interdomain communication in hepatitis C virus polymerase abolished by small molecule inhibitors bound to a novel allosteric site
S Di Marco, C Volpari, L Tomei, S Altamura, S Harper, F Narjes, U Koch, ...
Journal of Biological Chemistry 280 (33), 29765-29770, 2005
2072005
A designed P1 cysteine mimetic for covalent and non-covalent inhibitors of HCV NS3 protease
F Narjes, KF Koehler, U Koch, B Gerlach, S Colarusso, C Steinkühler, ...
Bioorganic & medicinal chemistry letters 12 (4), 701-704, 2002
2002002
A continuous assay of hepatitis C virus protease based on resonance energy transfer depsipeptide substrates
M Taliani, E Bianchi, F Narjes, M Fossatelli, A Urbani, C Steinkühler, ...
Analytical biochemistry 240 (1), 60-67, 1996
1681996
In vitro selection and characterization of hepatitis C virus serine protease variants resistant to an active-site peptide inhibitor
C Trozzi, L Bartholomew, A Ceccacci, G Biasiol, L Pacini, S Altamura, ...
Journal of Virology 77 (6), 3669-3679, 2003
1612003
2-(2-Thienyl)-5, 6-dihydroxy-4-carboxypyrimidines as inhibitors of the hepatitis C virus NS5B polymerase: discovery, SAR, modeling, and mutagenesis
U Koch, B Attenni, S Malancona, S Colarusso, I Conte, M Di Filippo, ...
Journal of Medicinal Chemistry 49 (5), 1693-1705, 2006
1582006
Inhibition of the hepatitis C virus NS3/4A protease: the crystal structures of two protease-inhibitor complexes
S Di Marco, M Rizzi, C Volpari, MA Walsh, F Narjes, S Colarusso, ...
Journal of Biological Chemistry 275 (10), 7152-7157, 2000
1492000
Recent progress in the development of inhibitors of the hepatitis C virus RNA-dependent RNA polymerase
U Koch, F Narjes
Current Topics in Medicinal Chemistry 7 (13), 1302-1329, 2007
1412007
Substrate specificity of the hepatitis C virus serine protease NS3
A Urbani, E Bianchi, F Narjes, A Tramontano, R De Francesco, ...
Journal of Biological Chemistry 272 (14), 9204-9209, 1997
1411997
Potent inhibitors of subgenomic hepatitis C virus RNA replication through optimization of indole-N-acetamide allosteric inhibitors of the viral NS5B polymerase
S Harper, S Avolio, B Pacini, M Di Filippo, S Altamura, L Tomei, ...
Journal of Medicinal Chemistry 48 (14), 4547-4557, 2005
1332005
Nucleoside aryl phosphoramidates for the treatment of RNA-dependent RNA viral infection
F Narjes, C Gardelli, M Donghi, B Attenni, PL Durette
US Patent 8,071,568, 2011
1212011
Characterization of the hepatitis C virus NS2/3 processing reaction by using a purified precursor protein
M Pallaoro, A Lahm, G Biasiol, M Brunetti, C Nardella, L Orsatti, F Bonelli, ...
Journal of virology 75 (20), 9939-9946, 2001
1212001
Development and preliminary optimization of indole-N-acetamide inhibitors of hepatitis C virus NS5B polymerase
S Harper, B Pacini, S Avolio, M Di Filippo, G Migliaccio, R Laufer, ...
Journal of Medicinal Chemistry 48 (5), 1314-1317, 2005
1162005
Nucleoside aryl phosphoramidates for the treatment of RNA-dependent RNA viral infection
M MacCoss, DB Olsen, M Donghi, C Gardelli, S Harper, M Meppen, ...
US Patent 7,879,815, 2011
1132011
Inhibitor binding induces active site stabilization of the HCV NS3 protein serine protease domain
G Barbato, DO Cicero, F Cordier, F Narjes, B Gerlach, S Sambucini, ...
The EMBO Journal, 2000
1102000
Bacteriohopanetetrol from chemical degradation of an oil shale kerogen
B Mycke, F Narjes, W Michaelis
Nature 326 (6109), 179-81, 1987
1001987
Nucleoside cyclic phosphoramidates for the treatment of RNA-dependent RNA viral infection
M Meppen, F Narjes, B Pacini, C Gardelli, PL Durette
US Patent 8,148,349, 2012
952012
Hepatitis C virus serine protease inhibitors: current progress and future challenges
C Steinkulher, U Kock, F Narjes, VG Matassa
Current medicinal chemistry 8 (8), 919-932, 2001
932001
α-Ketoacids are potent slow binding inhibitors of the hepatitis C virus NS3 protease
F Narjes, M Brunetti, S Colarusso, B Gerlach, U Koch, G Biasiol, D Fattori, ...
Biochemistry 39 (7), 1849-1861, 2000
912000
Phosphoramidate prodrugs of 2′-C-methylcytidine for therapy of hepatitis C virus infection
C Gardelli, B Attenni, M Donghi, M Meppen, B Pacini, S Harper, ...
Journal of Medicinal Chemistry 52 (17), 5394-5407, 2009
742009
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