Sam Hay
Sam Hay
Manchester Institute of Biotechnology (MIB) and Department of Chemistry, University of Manchester
Verified email at manchester.ac.uk - Homepage
Title
Cited by
Cited by
Year
Good vibrations in enzyme-catalysed reactions
S Hay, NS Scrutton
Nature chemistry 4 (3), 161-168, 2012
2412012
Reductive dehalogenase structure suggests a mechanism for B12-dependent dehalogenation
KAP Payne, CP Quezada, K Fisher, MS Dunstan, FA Collins, H Sjuts, ...
Nature 517 (7535), 513-516, 2015
1782015
New cofactor supports α, β-unsaturated acid decarboxylation via 1, 3-dipolar cycloaddition
KAP Payne, MD White, K Fisher, B Khara, SS Bailey, D Parker, ...
Nature 522 (7557), 497-501, 2015
1302015
UbiX is a flavin prenyltransferase required for bacterial ubiquinone biosynthesis
MD White, KAP Payne, K Fisher, SA Marshall, D Parker, NJW Rattray, ...
Nature 522 (7557), 502-506, 2015
1192015
Promoting motions in enzyme catalysis probed by pressure studies of kinetic isotope effects
S Hay, MJ Sutcliffe, NS Scrutton
Proceedings of the National Academy of Sciences 104 (2), 507-512, 2007
1092007
Quantum tunnelling in enzyme-catalysed reactions
RK Allemann, NS Scrutton
Royal Society of Chemistry, 2009
952009
Fast protein motions are coupled to enzyme H-transfer reactions
CR Pudney, A Guerriero, NJ Baxter, LO Johannissen, JP Waltho, S Hay, ...
Journal of the American Chemical Society 135 (7), 2512-2517, 2013
872013
Evidence to support the hypothesis that promoting vibrations enhance the rate of an enzyme catalyzed H-tunneling reaction
CR Pudney, S Hay, C Levy, J Pang, MJ Sutcliffe, D Leys, NS Scrutton
Journal of the American Chemical Society 131 (47), 17072-17073, 2009
852009
Direct Analysis of Donor− Acceptor Distance and Relationship to Isotope Effects and the Force Constant for Barrier Compression in Enzymatic H-Tunneling Reactions
CR Pudney, LO Johannissen, MJ Sutcliffe, S Hay, NS Scrutton
Journal of the American Chemical Society 132 (32), 11329-11335, 2010
812010
Deep tunneling dominates the biologically important hydride transfer reaction from NADH to FMN in morphinone reductase
J Pang, S Hay, NS Scrutton, MJ Sutcliffe
Journal of the American Chemical Society 130 (22), 7092-7097, 2008
802008
α-Secondary isotope effects as probes of “tunneling-ready” configurations in enzymatic H-tunneling: Insight from environmentally coupled tunneling models
CR Pudney, S Hay, MJ Sutcliffe, NS Scrutton
Journal of the American Chemical Society 128 (43), 14053-14058, 2006
752006
Proton tunneling in aromatic amine dehydrogenase is driven by a short-range sub-picosecond promoting vibration: consistency of simulation and theory with experiment
LO Johannissen, S Hay, NS Scrutton, MJ Sutcliffe
The Journal of Physical Chemistry B 111 (10), 2631-2638, 2007
652007
Barrier compression enhances an enzymatic hydrogen‐transfer reaction
S Hay, CR Pudney, TA McGrory, J Pang, MJ Sutcliffe, NS Scrutton
Angewandte Chemie 121 (8), 1480-1482, 2009
602009
Nature of the energy landscape for gated electron transfer in a dynamic redox protein
S Hay, S Brenner, B Khara, AM Quinn, SEJ Rigby, NS Scrutton
Journal of the American Chemical Society 132 (28), 9738-9745, 2010
562010
Conformational and thermodynamic control of electron transfer in neuronal nitric oxide synthase
AJ Dunford, SEJ Rigby, S Hay, AW Munro, NS Scrutton
Biochemistry 46 (17), 5018-5029, 2007
552007
Mutagenesis of morphinone reductase induces multiple reactive configurations and identifies potential ambiguity in kinetic analysis of enzyme tunneling mechanisms
CR Pudney, S Hay, J Pang, C Costello, D Leys, MJ Sutcliffe, NS Scrutton
Journal of the American Chemical Society 129 (45), 13949-13956, 2007
542007
Barrier compression and its contribution to both classical and quantum mechanical aspects of enzyme catalysis
S Hay, LO Johannissen, MJ Sutcliffe, NS Scrutton
Biophysical journal 98 (1), 121-128, 2010
522010
Are the catalytic properties of enzymes from piezophilic organisms pressure adapted?
S Hay, RM Evans, C Levy, EJ Loveridge, X Wang, D Leys, RK Allemann, ...
ChemBioChem 10 (14), 2348-2353, 2009
522009
Magnetic field effect studies indicate reduced geminate recombination of the radical pair in substrate-bound adenosylcobalamin-dependent ethanolamine ammonia lyase
AR Jones, S Hay, JR Woodward, NS Scrutton
Journal of the American Chemical Society 129 (50), 15718-15727, 2007
462007
Inter‐flavin electron transfer in cytochrome P450 reductase–effects of solvent and pH identify hidden complexity in mechanism
S Brenner, S Hay, AW Munro, NS Scrutton
The FEBS journal 275 (18), 4540-4557, 2008
452008
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