Sam Hay

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Nigel ScruttonProfessor of Enzymology, Manchester Institute of Biotechnology (MIB) and School of ChemistryVerified email at manchester.ac.uk
Linus JohannissenUniversity of ManchesterVerified email at manchester.ac.uk
David LeysProfessor in Structural Biology, Manchester UniversityVerified email at manchester.ac.uk
Mike SutcliffeDeputy Dean, TEDI-LondonVerified email at tedi-london.ac.uk
Christopher R PudneyReader in Biochemistry, University of BathVerified email at bath.ac.uk
Derren HeyesManchester Institute of Biotechnology, University of ManchesterVerified email at manchester.ac.uk
Colin LevyUniversity of Manchester, Manchester Protein Structure FacilityVerified email at manchester.ac.uk
Alex R. JonesPrincipal Research Scientist, National Physical LaboratoryVerified email at npl.co.uk
Karl PayneUniversity of ManchesterVerified email at manchester.ac.uk
Jiayun PangAssociate Professor, University of GreenwichVerified email at gre.ac.uk
Samantha J. O. HardmanManchester Institute of Biotechnology (MIB), University of ManchesterVerified email at manchester.ac.uk
Nicole G. H. LeferinkResearch Fellow Future BRH, Manchester Intsitute of Biotechnology (MIB), University of ManchesterVerified email at manchester.ac.uk
Andrew MunroProfessor of Molecular Enzymology, University of ManchesterVerified email at Manchester.ac.uk
Perdita BarranProfessor Mass Spectrometry University of ManchesterVerified email at manchester.ac.uk
David ParkerShell International Exploration and ProductionVerified email at shell.com
Eriko TakanoProfessor of Synthetic Biology, Manchester Institute of Biotechnology, University of ManchesterVerified email at manchester.ac.uk
Roy GoodacreDepartment of Biochemistry and Systems Biology, ISMIB, University of LiverpoolVerified email at liverpool.ac.uk
Drupad K TrivediCAMS Lecturer at University of Manchester; Manchester Institute of BiotechnologyVerified email at manchester.ac.uk
Nicholas J W RattrayChancellor's Fellow and LecturerVerified email at strath.ac.uk
Hanno SjutsSanofiVerified email at sanofi.com

Sam Hay

Professor of Biophysical Chemistry, University of Manchester

Verified email at manchester.ac.uk - Homepage

biophysical chemistry


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Good vibrations in enzyme-catalysed reactions S Hay, NS Scrutton Nature chemistry 4 (3), 161-168, 2012	262	2012
Reductive dehalogenase structure suggests a mechanism for B12-dependent dehalogenation KAP Payne, CP Quezada, K Fisher, MS Dunstan, FA Collins, H Sjuts, ... Nature 517 (7535), 513-516, 2015	229	2015
New cofactor supports α, β-unsaturated acid decarboxylation via 1, 3-dipolar cycloaddition KAP Payne, MD White, K Fisher, B Khara, SS Bailey, D Parker, ... Nature 522 (7557), 497-501, 2015	180	2015
UbiX is a flavin prenyltransferase required for bacterial ubiquinone biosynthesis MD White, KAP Payne, K Fisher, SA Marshall, D Parker, NJW Rattray, ... Nature 522 (7557), 502-506, 2015	159	2015
Quantum tunnelling in enzyme-catalysed reactions RK Allemann, NS Scrutton Royal Society of Chemistry, 2009	116	2009
Promoting motions in enzyme catalysis probed by pressure studies of kinetic isotope effects S Hay, MJ Sutcliffe, NS Scrutton Proceedings of the National Academy of Sciences 104 (2), 507-512, 2007	114	2007
Fast protein motions are coupled to enzyme H-transfer reactions CR Pudney, A Guerriero, NJ Baxter, LO Johannissen, JP Waltho, S Hay, ... Journal of the American Chemical Society 135 (7), 2512-2517, 2013	91	2013
Evidence to support the hypothesis that promoting vibrations enhance the rate of an enzyme catalyzed H-tunneling reaction CR Pudney, S Hay, C Levy, J Pang, MJ Sutcliffe, D Leys, NS Scrutton Journal of the American Chemical Society 131 (47), 17072-17073, 2009	91	2009
Direct Analysis of Donor− Acceptor Distance and Relationship to Isotope Effects and the Force Constant for Barrier Compression in Enzymatic H-Tunneling Reactions CR Pudney, LO Johannissen, MJ Sutcliffe, S Hay, NS Scrutton Journal of the American Chemical Society 132 (32), 11329-11335, 2010	85	2010
Deep tunneling dominates the biologically important hydride transfer reaction from NADH to FMN in morphinone reductase J Pang, S Hay, NS Scrutton, MJ Sutcliffe Journal of the American Chemical Society 130 (22), 7092-7097, 2008	84	2008
α-Secondary isotope effects as probes of “tunneling-ready” configurations in enzymatic H-tunneling: Insight from environmentally coupled tunneling models CR Pudney, S Hay, MJ Sutcliffe, NS Scrutton Journal of the American Chemical Society 128 (43), 14053-14058, 2006	81	2006
Carboxylesterase converts Amplex red to resorufin: Implications for mitochondrial H2O2 release assays S Miwa, A Treumann, A Bell, G Vistoli, G Nelson, S Hay, T von Zglinicki Free Radical Biology and Medicine 90, 173-183, 2016	70	2016
Proton tunneling in aromatic amine dehydrogenase is driven by a short-range sub-picosecond promoting vibration: consistency of simulation and theory with experiment LO Johannissen, S Hay, NS Scrutton, MJ Sutcliffe The Journal of Physical Chemistry B 111 (10), 2631-2638, 2007	67	2007
Barrier compression enhances an enzymatic hydrogen‐transfer reaction S Hay, CR Pudney, TA McGrory, J Pang, MJ Sutcliffe, NS Scrutton Angewandte Chemie 121 (8), 1480-1482, 2009	65	2009
Nature of the energy landscape for gated electron transfer in a dynamic redox protein S Hay, S Brenner, B Khara, AM Quinn, SEJ Rigby, NS Scrutton Journal of the American Chemical Society 132 (28), 9738-9745, 2010	64	2010
Conformational and thermodynamic control of electron transfer in neuronal nitric oxide synthase AJ Dunford, SEJ Rigby, S Hay, AW Munro, NS Scrutton Biochemistry 46 (17), 5018-5029, 2007	61	2007
Are the catalytic properties of enzymes from piezophilic organisms pressure adapted? S Hay, RM Evans, C Levy, EJ Loveridge, X Wang, D Leys, RK Allemann, ... ChemBioChem 10 (14), 2348-2353, 2009	59	2009
Barrier compression and its contribution to both classical and quantum mechanical aspects of enzyme catalysis S Hay, LO Johannissen, MJ Sutcliffe, NS Scrutton Biophysical journal 98 (1), 121-128, 2010	56	2010
Mutagenesis of morphinone reductase induces multiple reactive configurations and identifies potential ambiguity in kinetic analysis of enzyme tunneling mechanisms CR Pudney, S Hay, J Pang, C Costello, D Leys, MJ Sutcliffe, NS Scrutton Journal of the American Chemical Society 129 (45), 13949-13956, 2007	56	2007
Magnetic field effect studies indicate reduced geminate recombination of the radical pair in substrate-bound adenosylcobalamin-dependent ethanolamine ammonia lyase AR Jones, S Hay, JR Woodward, NS Scrutton Journal of the American Chemical Society 129 (50), 15718-15727, 2007	54	2007

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