| RAS proteins and their regulators in human disease DK Simanshu, DV Nissley, F McCormick Cell 170 (1), 17-33, 2017 | 1600 | 2017 |
| Dicer recognizes the 5 [prime] end of RNA for efficient and accurate processing JE Park*, I Heo*, Y Tian, DK Simanshu, H Chang, D Jee, DJ Patel, ... Nature 475 (7355), 201-205, 2011 | 672 | 2011 |
| Uridylation by TUT4 and TUT7 marks mRNA for degradation J Lim, M Ha, H Chang, SC Kwon, DK Simanshu, DJ Patel, VN Kim Cell 159 (6), 1365-1376, 2014 | 296 | 2014 |
| Non-vesicular trafficking by a ceramide-1-phosphate transfer protein regulates eicosanoids DK Simanshu*, RK Kamlekar*, DS Wijesinghe*, X Zou, X Zhai, SK Mishra, ... Nature 500 (7463), 463-467, 2013 | 197 | 2013 |
| Structural basis of recognition of farnesylated and methylated KRAS4b by PDEδ S Dharmaiah, L Bindu, TH Tran, WK Gillette, PH Frank, R Ghirlando, ... Proceedings of the National Academy of Sciences 113 (44), E6766-E6775, 2016 | 178 | 2016 |
| Atypical KRASG12R Mutant Is Impaired in PI3K Signaling and Macropinocytosis in Pancreatic Cancer GA Hobbs, NM Baker, AM Miermont, RD Thurman, M Pierobon, TH Tran, ... Cancer discovery 10 (1), 104-123, 2020 | 153 | 2020 |
| A Phosphate-Binding Pocket within the Platform-PAZ-Connector Helix Cassette of Human Dicer Y Tian*, DK Simanshu*, JB Ma, JE Park, I Heo, VN Kim, DJ Patel, ... Molecular Cell, 2014 | 152 | 2014 |
| KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation TH Tran, AH Chan, LC Young, L Bindu, C Neale, S Messing, ... Nature communications 12 (1), 1176, 2021 | 129 | 2021 |
| TUT 7 controls the fate of precursor micro RNA s by using three different uridylation mechanisms B Kim, M Ha, L Loeff, H Chang, DK Simanshu, S Li, M Fareh, DJ Patel, ... The EMBO journal 34 (13), 1801-1815, 2015 | 125 | 2015 |
| Structural basis for piRNA 2'-O-methylated 3'-end recognition by Piwi PAZ (Piwi/Argonaute/Zwille) domains Y Tian*, DK Simanshu*, JB Ma, DJ Patel, E contribution) Proceedings of the National Academy of Sciences 108 (3), 903-910, 2011 | 124 | 2011 |
| A dual flip-out mechanism for 5mC recognition by the Arabidopsis SUVH5 SRA domain and its impact on DNA methylation and H3K9 dimethylation in vivo E Rajakumara*, JA Law*, DK Simanshu, P Voigt, LM Johnson, ... Genes & Development 25 (2), 137-152, 2011 | 114 | 2011 |
| KRAS G13D sensitivity to neurofibromin-mediated GTP hydrolysis D Rabara, TH Tran, S Dharmaiah, RM Stephens, F McCormick, ... Proceedings of the National Academy of Sciences 116 (44), 22122-22131, 2019 | 98 | 2019 |
| INVOLVED IN DE NOVO 2-containing complex involved in RNA-directed DNA methylation in Arabidopsis I Ausin*, MVC Greenberg*, DK Simanshu*, CJ Hale, AA Vashisht, ... Proceedings of the National Academy of Sciences 109 (22), 8374-8381, 2012 | 94 | 2012 |
| Structural Basis of mRNA Recognition and Cleavage by Toxin MazF and Its Regulation by Antitoxin MazE in Bacillus subtilis DK Simanshu, Y Yamaguchi, JH Park, M Inouye, DJ Patel Molecular cell 52 (3), 447-458, 2013 | 92 | 2013 |
| Arabidopsis, Accelerated Cell Death 11, ACD11, Is a Ceramide-1-Phosphate Transfer Protein and Intermediary Regulator of Phytoceramide Levels DK Simanshu*, X Zhai*, D Munch, D Hofius, JE Markham, J Bielawski, ... Cell Reports, 2014 | 82 | 2014 |
| RIT1 oncoproteins escape LZTR1-mediated proteolysis P Castel, A Cheng, A Cuevas-Navarro, DB Everman, AG Papageorge, ... Science 363 (6432), 1226-1230, 2019 | 78 | 2019 |
| Multimeric assembly and biochemical characterization of the Trax–translin endonuclease complex Y Tian*, DK Simanshu*, M Ascano*, R Diaz-Avalos, AY Park, SA Juranek, ... Nature structural & molecular biology 18 (6), 658-664, 2011 | 76 | 2011 |
| Machine learning–driven multiscale modeling reveals lipid-dependent dynamics of RAS signaling proteins HI Ingólfsson, C Neale, TS Carpenter, R Shrestha, CA López, TH Tran, ... Proceedings of the National Academy of Sciences 119 (1), e2113297119, 2022 | 59 | 2022 |
| Structures of N-terminally processed KRAS provide insight into the role of N-acetylation S Dharmaiah, TH Tran, S Messing, C Agamasu, WK Gillette, W Yan, ... Scientific reports 9 (1), 10512, 2019 | 56 | 2019 |
| The small molecule BI-2852 induces a nonfunctional dimer of KRAS TH Tran, P Alexander, S Dharmaiah, C Agamasu, DV Nissley, ... Proceedings of the National Academy of Sciences 117 (7), 3363-3364, 2020 | 53 | 2020 |
Dinshaw J. PatelMemorial Sloan-Kettering Cancer CenterVerified email at mskcc.org
