| The coming of age of de novo protein design PS Huang, SE Boyken, D Baker Nature 537 (7620), 320-327, 2016 | 1325 | 2016 |
| Macromolecular modeling and design in Rosetta: recent methods and frameworks JK Leman, BD Weitzner, SM Lewis, J Adolf-Bryfogle, N Alam, RF Alford, ... Nature methods 17 (7), 665-680, 2020 | 559 | 2020 |
| De novo design of protein homo-oligomers with modular hydrogen-bond network–mediated specificity SE Boyken, Z Chen, B Groves, RA Langan, G Oberdorfer, A Ford, ... Science 352 (6286), 680-687, 2016 | 354 | 2016 |
| Crystal structures of the CusA efflux pump suggest methionine-mediated metal transport F Long, CC Su, MT Zimmermann, SE Boyken, KR Rajashankar, ... Nature 467 (7314), 484-488, 2010 | 258 | 2010 |
| De novo design of bioactive protein switches RA Langan, SE Boyken, AH Ng, JA Samson, G Dods, AM Westbrook, ... Nature 572 (7768), 205-210, 2019 | 249 | 2019 |
| Programmable design of orthogonal protein heterodimers Z Chen, SE Boyken, M Jia, F Busch, D Flores-Solis, MJ Bick, P Lu, ... Nature 565 (7737), 106-111, 2019 | 179 | 2019 |
| De novo design of modular and tunable protein biosensors A Quijano-Rubio, HW Yeh, J Park, H Lee, RA Langan, SE Boyken, ... Nature 591 (7850), 482-487, 2021 | 177 | 2021 |
| De novo design of protein logic gates Z Chen, RD Kibler, A Hunt, F Busch, J Pearl, M Jia, ZL VanAernum, ... Science 368 (6486), 78-84, 2020 | 177 | 2020 |
| Accurate computational design of multipass transmembrane proteins P Lu, D Min, F DiMaio, KY Wei, MD Vahey, SE Boyken, Z Chen, JA Fallas, ... Science 359 (6379), 1042-1046, 2018 | 169 | 2018 |
| Designed protein logic to target cells with precise combinations of surface antigens MJ Lajoie, SE Boyken, AI Salter, J Bruffey, A Rajan, RA Langan, ... Science 369 (6511), 1637-1643, 2020 | 143 | 2020 |
| De novo design of tunable, pH-driven conformational changes SE Boyken, MA Benhaim, F Busch, M Jia, MJ Bick, H Choi, JC Klima, ... Science 364 (6441), 658-664, 2019 | 142 | 2019 |
| Computational design of transmembrane pores C Xu, P Lu, TM Gamal El-Din, XY Pei, MC Johnson, A Uyeda, MJ Bick, ... Nature 585 (7823), 129-134, 2020 | 138 | 2020 |
| Rapid online buffer exchange for screening of proteins, protein complexes and cell lysates by native mass spectrometry ZL VanAernum, F Busch, BJ Jones, M Jia, Z Chen, SE Boyken, ... Nature protocols 15 (3), 1132-1157, 2020 | 114 | 2020 |
| Modular and tunable biological feedback control using a de novo protein switch AH Ng, TH Nguyen, M Gómez-Schiavon, G Dods, RA Langan, SE Boyken, ... Nature 572 (7768), 265-269, 2019 | 111 | 2019 |
| Multivalent designed proteins neutralize SARS-CoV-2 variants of concern and confer protection against infection in mice AC Hunt, JB Case, YJ Park, L Cao, K Wu, AC Walls, Z Liu, JE Bowen, ... Science translational medicine 14 (646), eabn1252, 2022 | 69 | 2022 |
| Rapid sampling of hydrogen bond networks for computational protein design JB Maguire, SE Boyken, D Baker, B Kuhlman Journal of chemical theory and computation 14 (5), 2751-2760, 2018 | 55 | 2018 |
| Dynamic allostery mediated by a conserved tryptophan in the Tec family kinases N Chopra, TE Wales, RE Joseph, SE Boyken, JR Engen, RL Jernigan, ... PLoS computational biology 12 (3), e1004826, 2016 | 53 | 2016 |
| Computational design of closely related proteins that adopt two well-defined but structurally divergent folds KY Wei, D Moschidi, MJ Bick, S Nerli, AC McShan, LP Carter, PS Huang, ... Proceedings of the National Academy of Sciences 117 (13), 7208-7215, 2020 | 51 | 2020 |
| Proline isomerization preorganizes the Itk SH2 domain for binding to the Itk SH3 domain A Severin, RE Joseph, S Boyken, DB Fulton, AH Andreotti Journal of molecular biology 387 (3), 726-743, 2009 | 51 | 2009 |
| Computational design of mechanically coupled axle-rotor protein assemblies A Courbet, J Hansen, Y Hsia, N Bethel, YJ Park, C Xu, A Moyer, ... Science 376 (6591), 383-390, 2022 | 43 | 2022 |
David BakerUniversity of WashingtonVerified email at uw.edu
