Professor John A Hartley
Professor John A Hartley
Professor of Cancer Studies
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Cited by
Cited by
Tracking the evolution of non–small-cell lung cancer
M Jamal-Hanjani, GA Wilson, N McGranahan, NJ Birkbak, TBK Watkins, ...
New England Journal of Medicine 376 (22), 2109-2121, 2017
Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution
C Abbosh, NJ Birkbak, GA Wilson, M Jamal-Hanjani, T Constantin, ...
Nature 545 (7655), 446-451, 2017
Allele-specific HLA loss and immune escape in lung cancer evolution
N McGranahan, R Rosenthal, CT Hiley, AJ Rowan, TBK Watkins, ...
Cell 171 (6), 1259-1271. e11, 2017
Hospital admission and emergency care attendance risk for SARS-CoV-2 delta (B. 1.617. 2) compared with alpha (B. 1.1. 7) variants of concern: a cohort study
KA Twohig, T Nyberg, A Zaidi, S Thelwall, MA Sinnathamby, S Aliabadi, ...
The Lancet Infectious Diseases 22 (1), 35-42, 2022
Defining the roles of nucleotide excision repair and recombination in the repair of DNA interstrand cross-links in mammalian cells
IU De Silva, PJ McHugh, PH Clingen, JA Hartley
Molecular and cellular biology 20 (21), 7980-7990, 2000
Fc effector function contributes to the activity of human anti-CTLA-4 antibodies
FA Vargas, AJS Furness, K Litchfield, K Joshi, R Rosenthal, E Ghorani, ...
Cancer cell 33 (4), 649-663. e4, 2018
Repair of DNA interstrand crosslinks: molecular mechanisms and clinical relevance
PJ McHugh, VJ Spanswick, JA Hartley
The lancet oncology 2 (8), 483-490, 2001
GC base sequence recognition by oligoimidazolecarboxamide and C-terminus-modified analogs of distamycin deduced from circular dichroism, proton nuclear magnetic resonance, and …
M Lee, AL Rhodes, MD Wyatt, S Forrow, JA Hartley
Biochemistry 32 (16), 4237-4245, 1993
Recurrent emergence of SARS-CoV-2 spike deletion H69/V70 and its role in the Alpha variant B. 1.1. 7
B Meng, SA Kemp, G Papa, R Datir, IATM Ferreira, S Marelli, WT Harvey, ...
Cell reports 35 (13), 2021
Fc-optimized anti-CD25 depletes tumor-infiltrating regulatory T cells and synergizes with PD-1 blockade to eradicate established tumors
FA Vargas, AJS Furness, I Solomon, K Joshi, L Mekkaoui, MH Lesko, ...
Immunity 46 (4), 577-586, 2017
Defective repair of cisplatin-induced DNA damage caused by reduced XPA protein in testicular germ cell tumours
B Köberle, JRW Masters, JA Hartley, RD Wood
Current Biology 9 (5), 273-278, 1999
bcl-2 Modulation of Apoptosis Induced by Anticancer Drugs: Resistance to Thymidylate Stress Is Independent of Classical Resistance Pathways
TC Fisher, AE Milner, CD Gregory, AL Jackman, GW Aherne, JA Hartley, ...
Cancer Research 53 (14), 3321-3326, 1993
DNA sequence selectivity of guanine–N7 alkylation by nitrogen mustards
WB Mattes, JA Hartley, KW Kohn
Nucleic acids research 14 (7), 2971-2987, 1986
Changes in symptomatology, reinfection, and transmissibility associated with the SARS-CoV-2 variant B. 1.1. 7: an ecological study
MS Graham, CH Sudre, A May, M Antonelli, B Murray, T Varsavsky, ...
The Lancet Public Health 6 (5), e335-e345, 2021
Design, synthesis, and evaluation of a novel pyrrolobenzodiazepine DNA-interactive agent with highly efficient cross-linking ability and potent cytotoxicity
SJ Gregson, PW Howard, JA Hartley, NA Brooks, LJ Adams, TC Jenkins, ...
Journal of medicinal chemistry 44 (5), 737-748, 2001
EGFR nuclear translocation modulates DNA repair following cisplatin and ionizing radiation treatment
G Liccardi, JA Hartley, D Hochhauser
Cancer research 71 (3), 1103-1114, 2011
Rational design of a highly efficient irreversible DNA interstrand cross-linking agent based on the pyrrolobenzodiazepine ring system
DS Bose, AS Thompson, J Ching, JA Hartley, MD Berardini, TC Jenkins, ...
Journal of the American chemical society 114 (12), 4939-4941, 1992
Mechanisms of DNA sequence selective alkylation of guanine-N7 positions by nitrogen mustards
KW Kohn, JA Hartley, WB Mattes
Nucleic acids research 15 (24), 10531-10549, 1987
The development of pyrrolobenzodiazepines as antitumour agents
JA Hartley
Expert opinion on investigational drugs 20 (6), 733-744, 2011
Synthesis of Sequence-Selective C8-Linked Pyrrolo[2,1-c][1,4]benzodiazepine DNA Interstrand Cross-Linking Agents
DE Thurston, DS Bose, AS Thompson, PW Howard, A Leoni, SJ Croker, ...
The Journal of Organic Chemistry 61 (23), 8141-8147, 1996
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