| Molecular pathways of motor neuron injury in amyotrophic lateral sclerosis L Ferraiuolo, J Kirby, AJ Grierson, M Sendtner, PJ Shaw Nature Reviews Neurology 7 (11), 616-630, 2011 | 683 | 2011 |
| Microglia induce motor neuron death via the classical NF-κB pathway in amyotrophic lateral sclerosis AE Frakes, L Ferraiuolo, AM Haidet-Phillips, L Schmelzer, L Braun, ... Neuron 81 (5), 1009-1023, 2014 | 651 | 2014 |
| The C9orf72 protein interacts with Rab1a and the ULK 1 complex to regulate initiation of autophagy CP Webster, EF Smith, CS Bauer, A Moller, GM Hautbergue, L Ferraiuolo, ... The EMBO journal 35 (15), 1656-1676, 2016 | 422 | 2016 |
| Direct conversion of patient fibroblasts demonstrates non-cell autonomous toxicity of astrocytes to motor neurons in familial and sporadic ALS K Meyer, L Ferraiuolo, CJ Miranda, S Likhite, S McElroy, S Renusch, ... Proceedings of the National Academy of Sciences 111 (2), 829-832, 2014 | 384 | 2014 |
| Applications of machine learning to diagnosis and treatment of neurodegenerative diseases MA Myszczynska, PN Ojamies, AMB Lacoste, D Neil, A Saffari, R Mead, ... Nature Reviews Neurology 16 (8), 440-456, 2020 | 381 | 2020 |
| Improving single injection CSF delivery of AAV9-mediated gene therapy for SMA: a dose–response study in mice and nonhuman primates K Meyer, L Ferraiuolo, L Schmelzer, L Braun, V McGovern, S Likhite, ... Molecular Therapy 23 (3), 477-487, 2015 | 301 | 2015 |
| Mutations in CHMP2B in lower motor neuron predominant amyotrophic lateral sclerosis (ALS) LE Cox, L Ferraiuolo, EF Goodall, PR Heath, A Higginbottom, H Mortiboys, ... PloS one 5 (3), e9872, 2010 | 297 | 2010 |
| Therapeutic AAV9-mediated suppression of mutant SOD1 slows disease progression and extends survival in models of inherited ALS KD Foust, DL Salazar, S Likhite, L Ferraiuolo, D Ditsworth, H Ilieva, ... Molecular Therapy 21 (12), 2148-2159, 2013 | 247 | 2013 |
| Dysregulation of astrocyte–motoneuron cross-talk in mutant superoxide dismutase 1-related amyotrophic lateral sclerosis L Ferraiuolo, A Higginbottom, PR Heath, S Barber, D Greenald, J Kirby, ... Brain 134 (9), 2627-2641, 2011 | 238 | 2011 |
| Microarray analysis of the cellular pathways involved in the adaptation to and progression of motor neuron injury in the SOD1 G93A mouse model of familial ALS L Ferraiuolo, PR Heath, H Holden, P Kasher, J Kirby, PJ Shaw Journal of Neuroscience 27 (34), 9201-9219, 2007 | 238 | 2007 |
| Gene expression profiling in human neurodegenerative disease J Cooper-Knock, J Kirby, L Ferraiuolo, PR Heath, M Rattray, PJ Shaw Nature Reviews Neurology 8 (9), 518-530, 2012 | 235 | 2012 |
| Oligodendrocytes contribute to motor neuron death in ALS via SOD1-dependent mechanism L Ferraiuolo, K Meyer, TW Sherwood, J Vick, S Likhite, A Frakes, ... Proceedings of the National Academy of Sciences 113 (42), E6496-E6505, 2016 | 193 | 2016 |
| Loss of nuclear TDP‐43 in amyotrophic lateral sclerosis (ALS) causes altered expression of splicing machinery and widespread dysregulation of RNA splicing in motor neurones JR Highley, J Kirby, JA Jansweijer, PS Webb, CA Hewamadduma, ... Neuropathology and applied neurobiology 40 (6), 670-685, 2014 | 192 | 2014 |
| Translational profiling identifies a cascade of damage initiated in motor neurons and spreading to glia in mutant SOD1-mediated ALS S Sun, Y Sun, SC Ling, L Ferraiuolo, M McAlonis-Downes, Y Zou, ... Proceedings of the National Academy of Sciences 112 (50), E6993-E7002, 2015 | 182 | 2015 |
| Micro-RNAs secreted through astrocyte-derived extracellular vesicles cause neuronal network degeneration in C9orf72 ALS A Varcianna, MA Myszczynska, LM Castelli, B O'Neill, Y Kim, J Talbot, ... EBioMedicine 40, 626-635, 2019 | 167 | 2019 |
| Delayed disease onset and extended survival in the SOD1G93A rat model of amyotrophic lateral sclerosis after suppression of mutant SOD1 in the motor cortex GM Thomsen, G Gowing, J Latter, M Chen, JP Vit, K Staggenborg, ... Journal of Neuroscience 34 (47), 15587-15600, 2014 | 155 | 2014 |
| Major histocompatibility complex class I molecules protect motor neurons from astrocyte-induced toxicity in amyotrophic lateral sclerosis SW Song, CJ Miranda, L Braun, K Meyer, AE Frakes, L Ferraiuolo, ... Nature medicine 22 (4), 397-403, 2016 | 140 | 2016 |
| SRSF1-dependent nuclear export inhibition of C9ORF72 repeat transcripts prevents neurodegeneration and associated motor deficits GM Hautbergue, LM Castelli, L Ferraiuolo, A Sanchez-Martinez, ... Nature communications 8 (1), 16063, 2017 | 136 | 2017 |
| Astrocyte adenosine deaminase loss increases motor neuron toxicity in amyotrophic lateral sclerosis SP Allen, B Hall, LM Castelli, L Francis, R Woof, AP Siskos, E Kouloura, ... Brain 142 (3), 586-605, 2019 | 102 | 2019 |
| Transcriptomic indices of fast and slow disease progression in two mouse models of amyotrophic lateral sclerosis G Nardo, R Iennaco, N Fusi, PR Heath, M Marino, MC Trolese, ... Brain 136 (11), 3305-3332, 2013 | 100 | 2013 |
Pamela J ShawProfessor of Neurology, University of SheffieldVerified email at sheffield.ac.uk
