| Crystal structure of fibroblast growth factor receptor ectodomain bound to ligand and heparin L Pellegrini, DF Burke, F von Delft, B Mulloy, TL Blundell Nature 407 (6807), 1029, 2000 | 793 | 2000 |
| Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity SS Ng, KL Kavanagh, MA McDonough, D Butler, ES Pilka, BMR Lienard, ... Nature 448 (7149), 87, 2007 | 286 | 2007 |
| Structures of ABCB10, a human ATP-binding cassette transporter in apo-and nucleotide-bound states CA Shintre, ACW Pike, Q Li, JI Kim, AJ Barr, S Goubin, L Shrestha, J Yang, ... Proceedings of the National Academy of Sciences 110 (24), 9710-9715, 2013 | 195 | 2013 |
| Crystal structures of the endoplasmic reticulum aminopeptidase-1 (ERAP1) reveal the molecular basis for N-terminal peptide trimming G Kochan, T Krojer, D Harvey, R Fischer, L Chen, M Vollmar, F von Delft, ... Proceedings of the National Academy of Sciences 108 (19), 7745-7750, 2011 | 190 | 2011 |
| Structure of the CaMKIIδ/calmodulin complex reveals the molecular mechanism of CaMKII kinase activation P Rellos, ACW Pike, FH Niesen, E Salah, WH Lee, F Von Delft, S Knapp PLoS biology 8 (7), e1000426, 2010 | 174 | 2010 |
| Structural basis for Cul3 protein assembly with the BTB-Kelch family of E3 ubiquitin ligases P Canning, CDO Cooper, T Krojer, JW Murray, ACW Pike, A Chaikuad, ... Journal of Biological Chemistry 288 (11), 7803-7814, 2013 | 143 | 2013 |
| Structure of the bone morphogenetic protein receptor ALK2 and implications for fibrodysplasia ossificans progressiva A Chaikuad, I Alfano, G Kerr, CE Sanvitale, JH Boergermann, JT Triffitt, ... Journal of Biological Chemistry 287 (44), 36990-36998, 2012 | 121 | 2012 |
| Identification of macrodomain proteins as novel O-acetyl-ADP-ribose deacetylases D Chen, M Vollmar, MN Rossi, C Phillips, R Kraehenbuehl, D Slade, ... Journal of Biological Chemistry 286 (15), 13261-13271, 2011 | 120 | 2011 |
| Crystal structure of aspartate decarboxylase at 2.2 Ċ resolution provides evidence for an ester in protein self–processing A Albert, V Dhanaraj, U Genschel, G Khan, MK Ramjee, R Pulido, ... Nature structural biology 5 (4), 289, 1998 | 109 | 1998 |
| The crystal structure of human GLRX5: iron–sulfur cluster co-ordination, tetrameric assembly and monomer activity C Johansson, AK Roos, SJ Montano, R Sengupta, P Filippakopoulos, ... Biochemical Journal 433 (2), 303-311, 2010 | 99 | 2010 |
| Structural snapshots for the conformation-dependent catalysis by human medium-chain acyl-coenzyme A synthetase ACSM2A G Kochan, ES Pilka, F von Delft, U Oppermann, WW Yue Journal of molecular biology 388 (5), 997-1008, 2009 | 98 | 2009 |
| Crystal structures of the catalytic domain of human soluble guanylate cyclase CK Allerston, F von Delft, O Gileadi PloS one 8 (3), e57644, 2013 | 97 | 2013 |
| Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases NR Rose, ECY Woon, A Tumber, LJ Walport, R Chowdhury, XS Li, ... Journal of medicinal chemistry 55 (14), 6639-6643, 2012 | 94 | 2012 |
| Ribosomal oxygenases are structurally conserved from prokaryotes to humans R Chowdhury, NC Brissett, T Krojer, C Ho, SS Ng, IJ Clifton, W Ge, ... Nature 510 (7505), 422, 2014 | 79 | 2014 |
| The crystal structure of E. coli pantothenate synthetase confirms it as a member of the cytidylyltransferase superfamily F von Delft, A Lewendon, V Dhanaraj, TL Blundell, C Abell, AG Smith Structure 9 (5), 439-450, 2001 | 79 | 2001 |
| The structural basis of ZMPSTE24-dependent laminopathies A Quigley, YY Dong, ACW Pike, L Dong, L Shrestha, G Berridge, ... Science 339 (6127), 1604-1607, 2013 | 74 | 2013 |
| Crystal structure of the PIM2 kinase in complex with an organoruthenium inhibitor AN Bullock, S Russo, A Amos, N Pagano, H Bregman, JE Debreczeni, ... PLoS One 4 (10), e7112, 2009 | 73 | 2009 |
| Targeting low-druggability bromodomains: fragment based screening and inhibitor design against the BAZ2B bromodomain FM Ferguson, O Fedorov, A Chaikuad, M Philpott, JRC Muniz, I Felletar, ... Journal of medicinal chemistry 56 (24), 10183-10187, 2013 | 72 | 2013 |
| Structural and mechanistic studies on γ-butyrobetaine hydroxylase IKH Leung, TJ Krojer, GT Kochan, L Henry, F von Delft, TDW Claridge, ... Chemistry & biology 17 (12), 1316-1324, 2010 | 68 | 2010 |
| The scientific impact of the Structural Genomics Consortium: a protein family and ligand-centered approach to medically-relevant human proteins O Gileadi, S Knapp, WH Lee, BD Marsden, S Müller, FH Niesen, ... Journal of structural and functional genomics 8 (2-3), 107-119, 2007 | 67 | 2007 |
Brian MarsdenSGC & Kennedy Institute of RheumatologyVerified email at sgc.ox.ac.uk
