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Ian Gilbert
Ian Gilbert
Head of Biological Chemistry and Drug Discovery, University of Dundee
Verified email at dundee.ac.uk - Homepage
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Cited by
Year
Automated design of ligands to polypharmacological profiles
J Besnard, GF Ruda, V Setola, K Abecassis, RM Rodriguiz, XP Huang, ...
Nature 492 (7428), 215-220, 2012
8212012
Lessons learnt from assembling screening libraries for drug discovery for neglected diseases
R Brenk, A Schipani, D James, A Krasowski, IH Gilbert, J Frearson, ...
ChemMedChem: Chemistry Enabling Drug Discovery 3 (3), 435-444, 2008
5312008
Towards the sustainable discovery and development of new antibiotics
M Miethke, M Pieroni, T Weber, M Brönstrup, P Hammann, L Halby, ...
Nature Reviews Chemistry 5 (10), 726-749, 2021
5212021
A novel multiple-stage antimalarial agent that inhibits protein synthesis
B Baragaña, I Hallyburton, MCS Lee, NR Norcross, R Grimaldi, TD Otto, ...
Nature 522 (7556), 315-320, 2015
4282015
Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need
MC Field, D Horn, AH Fairlamb, MAJ Ferguson, DW Gray, KD Read, ...
Nature Reviews Microbiology 15 (4), 217-231, 2017
4002017
N-myristoyltransferase inhibitors as new leads to treat sleeping sickness
JA Frearson, S Brand, SP McElroy, LAT Cleghorn, O Smid, L Stojanovski, ...
Nature 464 (7289), 728-732, 2010
3122010
Design and synthesis of a series of melamine-based nitroheterocycles with activity against trypanosomatid parasites
A Baliani, GJ Bueno, ML Stewart, V Yardley, R Brun, MP Barrett, IH Gilbert
Journal of medicinal chemistry 48 (17), 5570-5579, 2005
2342005
Drug discovery for neglected diseases: molecular target-based and phenotypic approaches: miniperspectives series on phenotypic screening for antiinfective targets
IH Gilbert
Journal of medicinal chemistry 56 (20), 7719-7726, 2013
2122013
Challenges and recent progress in drug discovery for tropical diseases
M De Rycker, B Baragaña, SL Duce, IH Gilbert
Nature 559 (7715), 498-506, 2018
1852018
Target assessment for antiparasitic drug discovery
JA Frearson, PG Wyatt, IH Gilbert, AH Fairlamb
Trends in parasitology 23 (12), 589-595, 2007
1822007
Fragment-based hit identification: thinking in 3D
AD Morley, A Pugliese, K Birchall, J Bower, P Brennan, N Brown, ...
Drug Discovery Today 18 (23-24), 1221-1227, 2013
1762013
Synthesis and Biological Evaluation of s-Triazine Substituted Polyamines as Potential New Anti-Trypanosomal Drugs
B Klenke, M Stewart, MP Barrett, R Brun, IH Gilbert
Journal of Medicinal Chemistry 44 (21), 3440-3452, 2001
1722001
Comparison of a high-throughput high-content intracellular Leishmania donovani assay with an axenic amastigote assay
M De Rycker, I Hallyburton, J Thomas, L Campbell, S Wyllie, D Joshi, ...
Antimicrobial agents and chemotherapy 57 (7), 2913-2922, 2013
1642013
Inhibitors of dihydrofolate reductase in Leishmania and trypanosomes
IH Gilbert
Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1587 (2-3 …, 2002
1602002
Dihydroquinazolines as a novel class of Trypanosoma brucei trypanothione reductase inhibitors: discovery, synthesis, and characterization of their binding mode by protein …
S Patterson, MS Alphey, DC Jones, EJ Shanks, IP Street, JA Frearson, ...
Journal of medicinal chemistry 54 (19), 6514-6530, 2011
1412011
Target validation: linking target and chemical properties to desired product profile
P G Wyatt, I H Gilbert, K D Read, A H Fairlamb
Current topics in medicinal chemistry 11 (10), 1275-1283, 2011
1412011
Screening Congo Red and its analogues for their ability to prevent the formation of PrP-res in scrapie-infected cells
H Rudyk, S Vasiljevic, RM Hennion, CR Birkett, J Hope, IH Gilbert
Journal of General Virology 81 (4), 1155-1164, 2000
1382000
Azasterols as Inhibitors of Sterol 24-Methyltransferase in Leishmania Species and Trypanosoma cruzi
F Magaraci, Jimenez, C Rodrigues, JCF Rodrigues, MV Braga, V Yardley, ...
Journal of medicinal chemistry 46 (22), 4714-4727, 2003
1272003
Preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition
S Wyllie, S Brand, M Thomas, M De Rycker, C Chung, I Pena, ...
Proceedings of the National Academy of Sciences 116 (19), 9318-9323, 2019
1222019
Cyclin-dependent kinase 12 is a drug target for visceral leishmaniasis
S Wyllie, M Thomas, S Patterson, S Crouch, M De Rycker, R Lowe, ...
Nature 560 (7717), 192-197, 2018
1212018
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