Antony W Oliver

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Laurence PearlProfessor of Structural Biology, University of SussexVerified email at sussex.ac.uk
Stuart RultenUniversity of SussexVerified email at sussex.ac.uk
Simon E WardCardiff UniversityVerified email at cardiff.ac.uk
Gabrielle GrundyResearch Fellow, Department of Molecular & Clinical Cancer Medicine, ISMIB, University of LiverpoolVerified email at liverpool.ac.uk
Geoff KnealeProfessor of Biomolecular Science, Portsmouth UniversityVerified email at port.ac.uk
Victoria AndersonAssociate Director, AdaptimmuneVerified email at adaptimmune.com
Stefan KnappUniversity of FrankfurtVerified email at pharmchem.uni-frankfurt.de
Christopher LordProfessor of Cancer Genomics, Institute of Cancer Research, London, UKVerified email at icr.ac.uk
Andrew N. BlackfordAssociate Professor, University of OxfordVerified email at imm.ox.ac.uk
Andreas LadurnerChair of Physiological Chemistry, LMU Munich; Founder, Managing Director and CSO, Eisbach Bio GmbHVerified email at med.lmu.de
Marek KozlowskiThe International Max Planck Research School for Molecular and Cellular Life Sciences, Martinsried, GermanyVerified email at med.lmu.de
Gyula TiminszkyBiological Research Centre of the Hungarian Academy of SciencesVerified email at brc.mta.hu
Fernando GarcesDirector, Biologics, Gilead SciencesVerified email at gilead.com
Dr. Thomas EtheridgeResearch Fellow, Genome Damage and Stability CentreVerified email at sussex.ac.uk
Helfrid HocheggerGDSC, University of SussexVerified email at sussex.ac.uk
Hung Quang DangResearch Scientist, Texas A & M UniversityVerified email at tamu.edu
Chris PontingChair of Medical Bioinformatics, University of EdinburghVerified email at igmm.ed.ac.uk
John DiffleyThe Francis Crick InstituteVerified email at crick.ac.uk
Sophie RobinsonBrighton and Sussex Medical SchoolVerified email at bsms.ac.uk
Timothy ChevassutReader and Consultant HaematologistVerified email at bsms.ac.uk

Antony W Oliver

Senior Research Fellow, University of Sussex

Verified email at sussex.ac.uk - Homepage

Structural Biology DNA Repair


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The zinc-finger domains of PARP1 cooperate to recognize DNA strand breaks AAE Ali, G Timinszky, R Arribas-Bosacoma, M Kozlowski, PO Hassa, ... Nature structural & molecular biology 19 (7), 685-692, 2012	310	2012
Structural basis for recruitment of BRCA2 by PALB2 AW Oliver, S Swift, CJ Lord, A Ashworth, LH Pearl EMBO reports 10 (9), 990-996, 2009	210	2009
Regulation of DNA replication through Sld3-Dpb11 interaction is conserved from yeast to humans D Boos, L Sanchez-Pulido, M Rappas, LH Pearl, AW Oliver, CP Ponting, ... Current Biology 21 (13), 1152-1157, 2011	184	2011
Crystal structure of the catalytic fragment of murine poly (ADP‐ribose) polymerase‐2 AW Oliver, JC Amé, SM Roe, V Good, G de Murcia, LH Pearl Nucleic acids research 32 (2), 456-464, 2004	176	2004
APLF promotes the assembly and activity of non‐homologous end joining protein complexes GJ Grundy, SL Rulten, Z Zeng, R Arribas‐Bosacoma, N Iles, K Manley, ... The EMBO journal 32 (1), 112-125, 2013	174	2013
Activation segment dimerization: a mechanism for kinase autophosphorylation of non‐consensus sites ACW Pike, P Rellos, FH Niesen, A Turnbull, AW Oliver, SA Parker, ... The EMBO journal 27 (4), 704-714, 2008	174	2008
Trans‐activation of the DNA‐damage signalling protein kinase Chk2 by T‐loop exchange AW Oliver, A Paul, KJ Boxall, SE Barrie, GW Aherne, MD Garrett, ... The EMBO journal 25 (13), 3179-3190, 2006	156	2006
TopBP1: A BRCT-scaffold protein functioning in multiple cellular pathways CP Wardlaw, AM Carr, AW Oliver DNA repair 22, 165-174, 2014	122	2014
CCT241533 is a potent and selective inhibitor of CHK2 that potentiates the cytotoxicity of PARP inhibitors VE Anderson, MI Walton, PD Eve, KJ Boxall, L Antoni, JJ Caldwell, ... Cancer research 71 (2), 463-472, 2011	118	2011
The XRCC1 phosphate-binding pocket binds poly (ADP-ribose) and is required for XRCC1 function C Breslin, P Hornyak, A Ridley, SL Rulten, H Hanzlikova, AW Oliver, ... Nucleic acids research 43 (14), 6934-6944, 2015	111	2015
Activation segment exchange: a common mechanism of kinase autophosphorylation? AW Oliver, S Knapp, LH Pearl Trends in biochemical sciences 32 (8), 351-356, 2007	103	2007
MDC1 interacts with TOPBP1 to maintain chromosomal stability during mitosis PA Leimbacher, SE Jones, AMK Shorrocks, M de Marco Zompit, M Day, ... Molecular cell 74 (3), 571-583. e8, 2019	100	2019
The ASCIZ-DYNLL1 axis promotes 53BP1-dependent non-homologous end joining and PARP inhibitor sensitivity JR Becker, R Cuella-Martin, M Barazas, R Liu, C Oliveira, AW Oliver, ... Nature communications 9 (1), 5406, 2018	91	2018
Chromatin association of the SMC5/6 complex is dependent on binding of its NSE3 subunit to DNA K Zabrady, M Adamus, L Vondrova, C Liao, H Skoupilova, M Novakova, ... Nucleic acids research 44 (3), 1064-1079, 2016	91	2016
Structure and function of the Rad9-binding region of the DNA-damage checkpoint adaptor TopBP1 M Rappas, AW Oliver, LH Pearl Nucleic acids research 39 (1), 313-324, 2011	89	2011
Structure of an archaeal PCNA1–PCNA2–FEN1 complex: elucidating PCNA subunit and client enzyme specificity AS Dore, ML Kilkenny, SA Jones, AW Oliver, SM Roe, SD Bell, LH Pearl Nucleic Acids Research 34 (16), 4515-4526, 2006	87	2006
Destabilized SMC5/6 complex leads to chromosome breakage syndrome with severe lung disease SN Van Der Crabben, MP Hennus, GA McGregor, DI Ritter, ... The Journal of clinical investigation 126 (8), 2881-2892, 2016	85	2016
Specific recognition of a multiply phosphorylated motif in the DNA repair scaffold XRCC1 by the FHA domain of human PNK AAE Ali, RM Jukes, LH Pearl, AW Oliver Nucleic acids research 37 (5), 1701-1712, 2009	83	2009
Efficient single-strand break repair requires binding to both poly (ADP-ribose) and DNA by the central BRCT domain of XRCC1 LM Polo, Y Xu, P Hornyak, F Garces, Z Zeng, R Hailstone, SJ Matthews, ... Cell reports 26 (3), 573-581. e5, 2019	76	2019
PARP3 is a sensor of nicked nucleosomes and monoribosylates histone H2B^Glu2 GJ Grundy, LM Polo, Z Zeng, SL Rulten, NC Hoch, P Paomephan, Y Xu, ... Nature communications 7 (1), 12404, 2016	76	2016

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